Three-Dimensional Electrospun Nanofiber Scaffolds: Fabrication Methods and Biomedical Applications [0.03%]
三维静电纺纳米纤维支架：制备方法与生物医学应用
Jinna Ke,Bingjie Han,Weiting Wang et al.
Jinna Ke et al.
Amid the rapid advancement in tissue engineering and regenerative medicine, 3D nanofiber scaffolds have attracted significant interest in the biomedical field for their ability to mimic the structure and function of the natural extracellula...
Biotechnological Control of Hydrogel Properties via Recombinant Protein Molecular Weight Engineering [0.03%]
利用重组蛋白分子量工程控制水凝胶性能的生物技术方法
Domenic Schlauch,Jan Peter Ebbecke,Amelie Paula von Alwörden et al.
Domenic Schlauch et al.
Hydrogels based on natural polymers are widely used in 3D cell culture and tissue engineering due to their biocompatibility and tunability. In this work, recombinant collagen-derived proteins of defined molecular weights were designed and t...
M2-Macrophage-Derived Extracellular Vesicles-Functionalized Acellular Dermal Matrix as a New-Generation Immunoregulatory and Angio-Inductive Construct for Skin Tissue Engineering [0.03%]
M2型巨噬细胞来源的外泌体功能化脱细胞真皮基质用于皮肤组织工程的新一代免疫调节和促血管生成构建体
Sevval Yazicioglu,Tugba Sezgin Arslan,Yasar Kemal Erdoğan et al.
Sevval Yazicioglu et al.
Extracellular vesicles, e.g., exosomes, derived from anti-inflammatory M2 macrophages have emerged as potent mediators of tissue regeneration through their ability to modulate cellular behavior, immune responses, and angiogenesis. In this s...
Targeted Delivery of Quercetin to the Brain via a Modified Polymeric Nanocarrier [0.03%]
一种改良型聚合物纳米载体介导的黄酮类化合物槲皮素脑靶向递送体系
Priyanshu Bhadane,Aniket Khairnar,Kalpana Pandya et al.
Priyanshu Bhadane et al.
Quercetin (Qt) exhibits significant neuroprotective potential in Alzheimer's disease; however, its clinical translation is limited by poor solubility, low permeability, and inadequate brain bioavailability. In this study, a modified polymer...
Identification of Novel Growth Factor Conjugated Nanofibers for Stimulation of Neuronal Growth [0.03%]
新型生长因子共轭纳米纤维的鉴定及其促神经生长作用
Yu-Liang Tsai,Karla K Rivera,Nayeong Jeon et al.
Yu-Liang Tsai et al.
Growth factors (GF) fulfil essential functions during organ development and regeneration. In tissue regeneration, evidence suggests that the combined application of several GFs is more efficient compared to their individual application. Sin...
Sonication Induced Self-Folding Hydrogels Based on SilMA-GelMA Composites for Cell-Laden Tissue Engineering Constructs [0.03%]
基于SilMA-GelMA复合材料的声空化诱导细胞负载的自折叠水凝胶用于组织工程构建体
Wenqian Xiao,Lu Wang,Jingzhi Yao et al.
Wenqian Xiao et al.
Swelling-dependent self-folding hydrogels show considerable promise for tissue engineering applications. However, current systems face limitations in cell growth within the passive layer. This study introduces a novel approach to developing...
Thermosensitive Injectable Sacran-Based Hydrogel with Superbroad Hydrophobic Domains for Rigid Drug-Controlled Release in Full-Thickness Skin Wound Therapy [0.03%]
一种用于全层皮肤伤口治疗的温度响应型可注射葡聚糖基超广疏水域刚性药物控制释放水凝胶
Chengqun Yu,Abid Naeem,Mohammad Asif Ali et al.
Chengqun Yu et al.
Persistent bacterial infections and prolonged inflammation often complicate full-thickness skin wound healing, underscoring the limitations of current dressings and the overuse of antibiotics. Herein, we developed a novel injectable hydroge...
Electrospun Nanofibrous Scaffolds for Peripheral Nerve Regeneration: From Biomaterial Design to Multimodal Therapeutic Integration [0.03%]
用于周围神经再生的电纺纳米纤维支架：从生物材料设计到多模式治疗整合
Bingjie Han,Jinna Ke,Ziao Tao et al.
Bingjie Han et al.
Electrospinning technology has shown great potential in the field of peripheral nerve injury repair due to its biomimetic fiber structure, controllable degradability, and multi-functional loading capacity. This article reviews the applicati...
Targeted Co-Delivery of Bioactives via Inhalable Folic Acid-Functionalized Chitosan Microparticles Induces Immunomodulation and Selective Cytokine Production in A549 Lung Cancer Cells [0.03%]
叶酸功能化壳聚糖微粒负载活性组分的靶向共递送诱导A549肺癌细胞免疫调节和选择性细胞因子产生
Tathagata Adhikary,Piyali Basak
Tathagata Adhikary
Despite advancements in cancer treatments, lung cancer is one of the most predominant cancer types responsible for a major contribution to cancer-related mortality on a global scale. Folate receptor alpha (FRα) is overexpressed in many epi...
Niclosamide Encapsulated pH-Responsive Polyzwitterionic Block Copolymers for Cancer Therapy [0.03%]
用于癌症治疗的pH响应型聚两性离子嵌段共聚物负载 Niclosamide疗法
Monu Pandey,Debojit Chakraborty,Shubhra Goel et al.
Monu Pandey et al.
Niclosamide (NIC) shows antitumor activity by inhibiting multiple signaling pathways, including signal transducer and activator of transcription 3, Wnt/β-catenin, and NF-κB. However, the poor aqueous solubility and bioavailability limit i...