Low-Field Actuating Magnetic Elastomer Membranes Characterized using Fibre-Optic Interferometry [0.03%]
利用光纤干涉测量法表征的低磁场驱动磁弹性体膜
Zhi Li,Joanna M Coote,Swathika Subburaman et al.
Zhi Li et al.
Smart robotic devices remotely powered by magnetic field have emerged as versatile tools for wide biomedical applications. Soft magnetic elastomer (ME) composite membranes with high flexibility and responsiveness are frequently incorporated...
On-Chip Reconstitution of Uniformly Shear-Sensing 3D Matrix-embedded Multicellular Blood Microvessel [0.03%]
嵌入均匀的剪切力感应三维基质的多细胞血液微管的芯片重建
Quoc Vo,Kaely A Carlson,Peter M Chiknas et al.
Quoc Vo et al.
Preclinical human-relevant modeling of organ-specific vasculature offers a unique opportunity to recreate pathophysiological intercellular, tissue-tissue, and cell-matrix interactions for a broad range of applications. Here, we present a re...
Rapid magnetically directed assembly of pre-patterned capillary-scale microvessels [0.03%]
预图案化毛细管微血管的快速磁导向组装
Maggie E Jewett,Harrison L Hiraki,Michał Wojasiński et al.
Maggie E Jewett et al.
Capillary scale vascularization is critical to the survival of engineered 3D tissues and remains an outstanding challenge for the field of tissue engineering. Current methods to generate micro-scale vasculature such as 3D printing, two phot...
Protocells Capable of Generating a Cytoskeleton-like Structure from intracellular Membrane-active Artificial Organelles [0.03%]
能够从细胞内膜活性人工细胞器中生成类似细胞骨架结构的原细胞
Dishi Wang,Silvia Moreno,Mengfei Gao et al.
Dishi Wang et al.
The intricate nature of eukaryotic cells with differently viscous intracellular compartments provides (membrane-active) enzymes to trigger time- and concentration-dependent processes in the intra-/extracellular matrix. Herein, we capitalize...
Creating Physicochemical Gradients in Modular Microporous Annealed Particle Hydrogels via a Microfluidic Method [0.03%]
通过微流体方法在模块化微孔退火粒子水凝胶中创建物理化学梯度
Shangjing Xin,Jing Dai,Carl A Gregory et al.
Shangjing Xin et al.
Microporous annealed particle (MAP) hydrogels are an attractive platform for engineering biomaterials with controlled heterogeneity. Here, we introduce a microfluidic method to create physicochemical gradients within poly(ethylene glycol) b...
In Vitro Prostate Cancer Treatment via CRISPR-Cas9 Gene Editing Facilitated by Polyethyleneimine-Derived Graphene Quantum Dots [0.03%]
通过聚乙烯亚胺衍生的石墨烯量子点促进CRISPR-Cas9基因编辑来治疗体外前列腺癌
Bong Lee,Klara Gries,Alina R Valimukhametova et al.
Bong Lee et al.
CRISPR-Cas9 is a programmable gene editing tool with a promising potential for cancer gene therapy. This therapeutic function is enabled in the present work via the non-covalent delivery of CRISPR ribonucleic protein (RNP) by cationic gluco...
A Facile Strategy for the Fabrication of Cell-laden Porous Alginate Hydrogels Based on Two-phase Aqueous Emulsions [0.03%]
基于两相水包水乳液的载细胞藻酸盐凝胶的简易制备策略
Wen Xue,Donghee Lee,Yunfan Kong et al.
Wen Xue et al.
Porous alginate hydrogels possess many advantages as cell carriers. However, current pore generation methods require either complex or harsh fabrication processes, toxic components, or extra purification steps, limiting the feasibility and ...
Hybrid Shear-thinning Hydrogel Integrating Hyaluronic Acid with ROS-Responsive Nanoparticles [0.03%]
集成了透明质酸和ROS响应型纳米粒子的杂化剪切变稀水凝胶
Mariah G Bezold,Andrew R Hanna,Bryan R Dollinger et al.
Mariah G Bezold et al.
Nanoparticle (NP) supra-assembly offers unique opportunities to tune macroscopic hydrogels' mechanical strength, material degradation, and drug delivery properties. Here, synthetic, reactive oxygen species (ROS)-responsive NPs are physicall...
Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors [0.03%]
用于识别肌肉恢复因子的三维微生理系统中的工程异龄体实验研究
Yunki Lee,Jeongmoon J Choi,Song Ih Ahn et al.
Yunki Lee et al.
Exposure of aged mice to a young systemic milieu revealed remarkable rejuvenation effects on aged tissues, including skeletal muscle. Although some candidate factors have been identified, the exact identity and the underlying mechanisms of ...
Hydration-induced Void-containing Hydrogels for Encapsulation and Sustained Release of Small Hydrophilic Molecules [0.03%]
用于包封和持续释放小亲水分子的保水性含孔水凝胶
Qi Li,Xiaosi Li,Elizabeth Bury et al.
Qi Li et al.
Efficient encapsulation and sustained release of small hydrophilic molecules from traditional hydrogel systems have been challenging due to the large mesh size of 3D networks and high water content. Furthermore, the encapsulated molecules a...