Exploring and Analyzing the Systemic Delivery Barriers for Nanoparticles [0.03%]
用于纳米颗粒的系统传输障碍的研究与分析
Lin Wang,Skyler Quine,Alex N Frickenstein et al.
Lin Wang et al.
Most nanomedicines require efficient in vivo delivery to elicit diagnostic and therapeutic effects. However, en route to their intended tissues, systemically administered nanoparticles often encounter delivery barriers. To describe these ba...
FRET Sensor-Modified Synthetic Hydrogels for Real-Time Monitoring of Cell-Derived Matrix Metalloproteinase Activity using Fluorescence Lifetime Imaging [0.03%]
荧光寿命成像实时监测细胞衍生基质金属蛋白酶活性的FRET传感器修饰合成水凝胶
Ziqian Yan,Thomas Kavanagh,Ricardo da Silva Harrabi et al.
Ziqian Yan et al.
Matrix remodeling plays central roles in a range of physiological and pathological processes and is driven predominantly by the activity of matrix metalloproteinases (MMPs), which degrade extracellular matrix (ECM) proteins. Our understandi...
Engineering Stem Cell Fate Controlling Biomaterials to Develop Muscle Connective Tissue Layered Myofibers [0.03%]
工程化控制干细胞命运的生物材料以开发具有肌腱组织层的肌肉纤维
Seokgyu Han,Myung Chul Lee,Alejandra Rodríguez-delaRosa et al.
Seokgyu Han et al.
Skeletal muscle connective tissue (MCT) surrounds myofiber bundles to provide structural support, produce force transduction from tendons, and regulate satellite cell differentiation during muscle regeneration. Engineered muscle tissue comp...
Microengineering 3D Collagen Matrices with Tumor-Mimetic Gradients in Fiber Alignment [0.03%]
具有肿瘤模拟纤维排列的三维胶原矩阵微工程学
Indranil M Joshi,Mehran Mansouri,Adeel Ahmed et al.
Indranil M Joshi et al.
Collagen fibers in the 3D tumor microenvironment (TME) exhibit complex alignment landscapes that are critical in directing cell migration through a process called contact guidance. Previous in vitro work studying this phenomenon has focused...
A Protein-Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix-Dependent Stiffness Responses [0.03%]
一种具有可调刚度的蛋白质吸附水凝胶用于组织培养展示出与基质相关的刚性响应特性
Linqing Li,Megan E Griebel,Marina Uroz et al.
Linqing Li et al.
Although tissue culture plastic has been widely employed for cell culture, the rigidity of plastic is not physiologic. Softer hydrogels used to culture cells have not been widely adopted in part because coupling chemistries are required to ...
Sungchul Shin,Lucia G Brunel,Betty Cai et al.
Sungchul Shin et al.
While the human body has many different examples of perfusable structures with complex geometries, biofabrication methods to replicate this complexity are still lacking. Specifically, the fabrication of self-supporting, branched networks wi...
Injectable Shear-Thinning Hydrogels with Sclerosing and Matrix Metalloproteinase Modulatory Properties for the Treatment of Vascular Malformations [0.03%]
一种可注射的剪切变稀水凝胶及其治疗血管畸形的用途及使用方法
Fatemeh Zehtabi,Ankit Gangrade,Kaylee Tseng et al.
Fatemeh Zehtabi et al.
Sac embolization of abdominal aortic aneurysms (AAAs) remains clinically limited by endoleak recurrences. These recurrences are correlated with recanalization due to the presence of endothelial lining and matrix metalloproteinases (MMPs)-me...
Ran Li,Thomas S C Ng,Michelle A Garlin et al.
Ran Li et al.
Engineered materials are ubiquitous in biomedical applications ranging from systemic drug delivery systems to orthopedic implants, and their actions unfold across multiple time- and length-scales. The efficacy and safety of biologics, nanom...
A highly sensitive and long-term stable wearable patch for continuous analysis of biomarkers in sweat [0.03%]
一种用于连续分析汗液生物标志物的高度灵敏且长期稳定的可穿戴贴片
Farnaz Lorestani,Xianzhe Zhang,Abu Musa Abdullah et al.
Farnaz Lorestani et al.
Although increasing efforts have been devoted to the development of non-invasive wearable or stretchable electrochemical sweat sensors for monitoring physiological and metabolic information, most of them still suffer from poor stability and...
Tunable Interparticle Connectivity in Gold Nanosphere Assemblies for Efficient Photoacoustic Conversion [0.03%]
金纳米球装配中的可调谐粒子间连接性应用于高效的光声转换
Myeongsoo Kim,Jinhwan Kim,Don VanderLaan et al.
Myeongsoo Kim et al.
Manipulating matter at the nanometer scale to create desired plasmonic nanostructures holds great promise in the field of biomedical photoacoustic (PA) imaging. We demonstrate a strategy for regulating PA signal generation from anisotropic ...