Georgios A Sotiriou,Takumi Sannomiya,Alexandra Teleki et al.
Georgios A Sotiriou et al.
The plasmonic properties of noble metals facilitate their use for in-vivo bio-applications such as targeted drug delivery and cancer cell therapy. Nanosilver is best suited for such applications as it has the lowest plasmonic losses among a...
Boaz Mizrahi,Sahadev A Shankarappa,Julia M Hickey et al.
Boaz Mizrahi et al.
Injectable materials often have shortcomings in mechanical and drug-eluting properties that are attributable to their high water contents. A water-free, liquid four-armed PEG modified with dopamine end groups is described which changed from...
Self-assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer [0.03%]
用于原发性乳腺癌局部治疗的丝素水凝胶自装载体多药控释体系研究
F Philipp Seib,Eleanor M Pritchard,David L Kaplan
F Philipp Seib
Standard care for early stage breast cancer includes tumor resection and local radiotherapy to achieve long-term remission. Systemic chemotherapy provides only low locoregional control of the disease; therefore, we describe self-assembling ...
Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery [0.03%]
用于改善经皮药物输送的形成水凝胶的微针阵列
Ryan F Donnelly,Thakur Raghu Raj Singh,Martin J Garland et al.
Ryan F Donnelly et al.
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached...
Sung Min Kang,Nathaniel S Hwang,Jihyeon Yeom et al.
Sung Min Kang et al.
Surface modification is one of the most important techniques in modern science and engineering. The facile introduction of a wide variety of desired properties onto virtually any material surface is an ultimate goal in surface chemistry. To...
Enhancing the Cellular Delivery of Nanoparticles using Lipo-Oligoarginine Peptides [0.03%]
利用Lipo-寡精氨酸肽增强纳米颗粒的细胞递送能力
Jae Sam Lee,Ching-Hsuan Tung
Jae Sam Lee
Nanoparticles have great potential as nanotherapeutics, delivery vectors, and molecular imaging agents due to their flexible properties. Although intracellular and nuclear delivery of nanoparticles is desirable for therapeutic applications,...
Ultrathin polymeric coatings based on hydrogen-bonded polyphenol for protection of pancreatic islet cells [0.03%]
基于氢键多酚的超薄聚合物涂层用于保护胰岛细胞
Veronika Kozlovskaya,Oleksandra Zavgorodnya,Yi Chen et al.
Veronika Kozlovskaya et al.
Though transplantation of pancreatic islet cells has emerged as a promising treatment for Type 1 diabetes its clinical application remains limited due to a number of limitations including both pathogenic innate and adaptive immune responses...
Integration of Self-Assembled Microvascular Networks with Microfabricated PEG-Based Hydrogels [0.03%]
基于PEG的微加工水凝胶与自组装微血管网络集成
Michael P Cuchiara,Daniel J Gould,Melissa K McHale et al.
Michael P Cuchiara et al.
Despite tremendous efforts, tissue engineered constructs are restricted to thin, simple tissues sustained only by diffusion. The most significant barrier in tissue engineering is insufficient vascularization to deliver nutrients and metabol...
A biologically active surface enzyme assembly that attenuates thrombus formation [0.03%]
一种能够抑制血栓形成的具有生物活性的表面酶组合物
Zheng Qu,Sharmila Muthukrishnan,Murali K Urlam et al.
Zheng Qu et al.
Activation of hemostatic pathways by blood-contacting materials remains a major hurdle in the development of clinically durable artificial organs and implantable devices. We postulate that surface-induced thrombosis may be attenuated by the...
Biomimetic Design of Protein Nanomaterials for Hydrophobic Molecular Transport [0.03%]
仿生设计蛋白质纳米材料进行疏水分子输运
Dongmei Ren,Mercè Dalmau,Arlo Randall et al.
Dongmei Ren et al.
Biomaterials such as self-assembling biological complexes have demonstrated a variety of applications in materials science and nanotechnology. The functionality of protein-based materials, however, is often limited by the absence or locatio...