Polymer-Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications [0.03%]
基于聚合物的硝基氧化物疗法：生物医学应用的新见解
Michele C Jen,María C Serrano,Robert van Lith et al.
Michele C Jen et al.
Since the discovery of nitric oxide (NO) in the 1980s, this cellular messenger has been shown to participate in diverse biological processes such as cardiovascular homeostasis, immune response, wound healing, bone metabolism, and neurotrans...
A DNA-Device that Mediates Selective Endosomal Escape and Intracellular Delivery of Drugs and Biologicals [0.03%]
一种介导药物和生物制剂选择性进入内体及细胞递送的DNA设备
Silvia Muro
Silvia Muro
Design of materials to aid intracellular delivery of agents can greatly improve medical treatments. While DNA is a molecule difficult to introduce into cells, DNA can be engineered into devices capable of intracellular delivery. Yet, transp...
A fabricated siRNA nanoparticle for ultra-long gene silencing in vivo [0.03%]
一种用于体内超长基因沉默的仿生纳米颗粒递送siRNA的新方法
Seung Koo Lee,Ching-Hsuan Tung
Seung Koo Lee
Persistent gene silencing is crucially required for the successful therapeutics of short interfering RNA (siRNA). Here, we describe a nanoparticle based delivery system which assembled by layering siRNAs between protease degradable polypept...
Inflammatory cytokines presented from polymer matrices differentially generate and activate DCs in situ [0.03%]
多聚体矩阵展示的炎性细胞因子不同地产生和激活局部DCs
Omar A Ali,Prakriti Tayalia,Dmitry Shvartsman et al.
Omar A Ali et al.
During infection, inflammatory cytokines mobilize and activate dendritic cells (DCs), which are essential for efficacious T cell priming and immune responses that clear the infection. Here we designed macroporous poly(lactide-co-glycolide) ...
Composite three-dimensional woven scaffolds with interpenetrating network hydrogels to create functional synthetic articular cartilage [0.03%]
互穿网络水凝胶的复合三维织物支架以制造功能性合成关节软骨
I-Chien Liao,Franklin T Moutos,Bradley T Estes et al.
I-Chien Liao et al.
The development of synthetic biomaterials that possess mechanical properties that mimic those of native tissues remains an important challenge to the field of materials. In particular, articular cartilage is a complex nonlinear, viscoelasti...
Regulation of Stem Cell Fate in a Three-Dimensional Micropatterned Dual-Crosslinked Hydrogel System [0.03%]
三维微图案双重交联水凝胶系统中干细胞 fate的调节
Oju Jeon,Eben Alsberg
Oju Jeon
Micropatterning technology is a powerful tool for controlling the cellular microenvironment and investigating the effects of physical parameters on cell behaviors, such as migration, proliferation, apoptosis, and differentiation. Although t...
Iron Oxide-labeled Collagen Scaffolds for Non-invasive MR Imaging in Tissue Engineering [0.03%]
铁氧化物标记胶原支架在组织工程中非侵入式磁共振成像中的应用
Marianne E Mertens,Alina Hermann,Anne Bühren et al.
Marianne E Mertens et al.
Non-invasive imaging holds significant potential for implementation in tissue engineering. It can e.g. be used to monitor the localization and function of tissue-engineered implants, as well as their resorption and remodelling. Thus far, ho...
Haiyun Ma,Jiang Hu,Peter X Ma
Haiyun Ma
To better engineer small-diameter blood vessels, a few types of novel scaffolds were fabricated from biodegradable poly(L-lactic acid) (PLLA) by means of thermally induced phase separation (TIPS) techniques. By utilizing the differences in ...
Highly Elastic Micropatterned Hydrogel for Engineering Functional Cardiac Tissue [0.03%]
一种用于工程化功能心肌组织的高弹微图案水凝胶
Nasim Annabi,Kelly Tsang,Suzanne M Mithieux et al.
Nasim Annabi et al.
Heart failure is a major international health issue. Myocardial mass loss and lack of contractility are precursors to heart failure. Surgical demand for effective myocardial repair is tempered by a paucity of appropriate biological material...
Endosomolytic anionic polymer for the cytoplasmic delivery of siRNAs in localized in vivo applications [0.03%]
用于局部体内应用的siRNA胞质递送的内体溶解释酸性聚合物
Sariah Khormaee,Yong Choi,Michael J Shen et al.
Sariah Khormaee et al.
The use of small interfering RNAs (siRNAs) to down-regulate the expression of disease-associated proteins carries significant promise for the treatment of a variety of clinical disorders. One of the main barriers to the widespread clinical ...