Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer [0.03%]
用于精确共载吉西他滨单磷酸盐和顺铂治疗膀胱癌的纳米颗粒
Lei Miao,Shutao Guo,Jing Zhang et al.
Lei Miao et al.
Combination chemotherapy is a common practice in clinical management of malignancy. Synergistic therapeutic outcome is only achieved when tumor cells are exposed to cells in an optimal ratio. However, due to diverse physicochemical properti...
Benjamin P Partlow,Craig W Hanna,Jelena Rnjak-Kovacina et al.
Benjamin P Partlow et al.
Elastomeric, fully degradable and biocompatible biomaterials are rare, with current options presenting significant limitations in terms of ease of functionalization and tunable mechanical and degradation properties. We report a new method f...
Arrayed Hollow Channels in Silk-based Scaffolds Provide Functional Outcomes for Engineering Critically-sized Tissue Constructs [0.03%]
基于丝素蛋白的阵列空心通道支架用于工程化大尺寸组织构建体的功能性研究
Jelena Rnjak-Kovacina,Lindsay S Wray,Julianne M Golinski et al.
Jelena Rnjak-Kovacina et al.
In the field of regenerative medicine there is a need for scaffolds that support large, critically-sized tissue formation. Major limitations in reaching this goal are the delivery of oxygen and nutrients throughout the bulk of the engineere...
Film-based Implants for Supporting Neuron-Electrode Integrated Interfaces for The Brain [0.03%]
基于胶片的脑机接口神经植入物
Min D Tang-Schomer,Xiao Hu,Marie Tupaj et al.
Min D Tang-Schomer et al.
Neural engineering provides promise for cell therapy by integrating the host brain with brain-machine-interface technologies in order to externally modulate functions. Long-term interfaces with the host brain remain a critical challenge due...
Dynamic Electrochemical Membranes for Continuous Affinity Protein Separation [0.03%]
用于连续亲和蛋白质分离的动态电化学膜技术
Zhiqiang Chen,Tao Chen,Xinghua Sun et al.
Zhiqiang Chen et al.
A membrane system with nm-scale thick electrodes is able to selectively bind genetically modified proteins and pump them across the membrane with sequential voltage pulses. The electrodes are located at the first 20nm of pore entrances to s...
Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery [0.03%]
用于可调双生长因子输送的多层无机微粒
Xiaohua Yu,Andrew Khalil,Phuong Ngoc Dang et al.
Xiaohua Yu et al.
There is an increasing need to control the type, quantity, and timing of growth factors released during tissue healing. Sophisticated delivery systems offering the ability to deliver multiple growth factors with independently tunable kineti...
Stefan T Yohe,Jonathan D Freedman,Eric J Falde et al.
Stefan T Yohe et al.
Superhydrophobic, porous, 3D materials composed of poly( ε -caprolactone) (PCL) and the hydrophobic polymer dopant poly(glycerol monostearate- co- ε -caprolactone) (PGC-C18) are fabricated using the electrospinning technique. These 3D mat...
Matrix Metalloproteinase Responsive, Proximity-activated Polymeric Nanoparticles for siRNA Delivery [0.03%]
一种基质金属蛋白酶响应、近程激活的用于siRNA递送的聚合物纳米粒子
Hongmei Li,Shann S Yu,Martina Miteva et al.
Hongmei Li et al.
Small interfering RNA (siRNA) has significant potential to evolve into a new class of pharmaceutical inhibitors, but technologies that enable robust, tissue-specific intracellular delivery must be developed before effective clinical transla...
Rigidity-patterned polyelectrolyte films to control myoblast cell adhesion and spatial organization [0.03%]
rigidity-图案化聚电解质膜控制肌管细胞粘附和空间构型
Claire Monge,Naresh Saha,Thomas Boudou et al.
Claire Monge et al.
In vivo, cells are sensitive to the stiffness of their micro-environment and especially to the spatial organization of the stiffness. In vitro studies of this phenomenon can help to better understand the mechanisms of the cell response to s...
Charge-Tunable Silk-Tropoelastin Protein Alloys That Control Neuron Cell Responses [0.03%]
带电可调的丝蛋白-弹性蛋白体蛋白质合金及其控制神经细胞反应的能力
Xiao Hu,Min D Tang-Schomer,Wenwen Huang et al.
Xiao Hu et al.
Tunable protein composites are important for constructing extracellular matrix mimics of human tissues with control of biochemical, structural, and mechanical properties. Molecular interaction mechanisms between silk fibroin protein and rec...