Multifunctional Superparamagnetic Copper Iron Oxide Nanoparticles for Synergistic Cancer Therapy via Magnetic Hyperthermia, Oxidative Stress and Immune Reprogramming [0.03%]
磁性超顺磁性铜铁氧化物纳米粒子的多功能性通过磁热疗，氧化应激和免疫重编程实现协同癌症治疗的能力
Yuxin Cai,Xuejia Kang,Lang Zhou et al.
Yuxin Cai et al.
Aggressive cancers, characterized by high metastatic potential and resistance to conventional therapies, present a significant challenge in oncology. Current treatments often fail to effectively target metastasis, recurrence, and the immuno...
Twinkling Peptide Nanoemulsions Enable Precision Ultrasound Detection of Atherosclerotic Plaques [0.03%]
闪烁肽纳米乳剂可实现动脉粥样硬化斑块的精准超声检测
Inhye Kim,Jacob C Elliott,Atip Lawanprasert et al.
Inhye Kim et al.
Non-invasive imaging modalities that identify rupture-prone atherosclerotic plaques hold promise to improve patient risk stratification and advance early intervention strategies. Here, phase-changing peptide nanoemulsions are developed as t...
Continuous Production of Highly Functional Vascularized Hepatobiliary Organoids from Human Pluripotent Stem Cells using a Scalable Microfluidic Platform [0.03%]
基于人类多能干细胞的血管化肝胆器官芯片的连续生产
Saeed Abbasalizadeh,Sahab Babaee,Reza Kowsari-Esfahan et al.
Saeed Abbasalizadeh et al.
"Organoid medicine" has rapidly progressed over the past decade as a new class of therapeutics with high functionality and complexity for addressing unmet medical needs such as effective treatment of patients suffering from chronic liver di...
Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neurostimulation Technology Development [0.03%]
超小型碳电极光电动势刺激神经组织的潜力——神经刺激技术发展的新方向
Keying Chen,Bingchen Wu,Daniela Krahe et al.
Keying Chen et al.
Neuromodulation technologies have gained considerable attention for their clinical potential in treating neurological disorders and advancing cognition research. However, traditional methods like electrical stimulation and optogenetics face...
A Pumpless, High-Throughput Microphysiological System to Mimic Enteric Innervation of Duodenal Epithelium and the Impact on Barrier Function [0.03%]
一种无泵浦、高通量的微生理系统模仿肠神经系统对十二指肠上皮屏障功能的影响
Kyla N Kaiser,Jessica R Snyder,Ryan A Koppes et al.
Kyla N Kaiser et al.
Enteric neurons are critical in maintaining organ homeostasis within the small intestine, and their dysregulation are implicated in gastrointestinal disorders and neurodegenerative diseases. Most in vitro models lack enteric innervation, li...
Precision-Engineered Cobalt-doped Iron Oxide Nanoparticles: From Octahedron Seeds to Cubical Bipyramids for Enhanced Magnetic Hyperthermia [0.03%]
精准工程 cobalt 掺杂铁氧化纳米颗粒：从八面体种子到立方双锥以增强磁性超声热疗
Prem Singh,Karthickraja Duraisamy,Constanze Raitmayr et al.
Prem Singh et al.
Despite notable advancements, the significantly improved yet suboptimal heating efficiency of current magnetic nanoparticles hinders the effectiveness of systemically delivered magnetic hyperthermia in reducing tumor size or halting growth....
Microbubble-Controlled Delivery of Biofilm-Targeting Nanoparticles to Treat MRSA Infection [0.03%]
微泡控制靶向生物膜纳米颗粒用于治疗MRSA感染
Ju Yeon Chung,Yujin An,Joo Hun Lee et al.
Ju Yeon Chung et al.
Drug-resistant microorganisms cause serious problems in human healthcare, leading to the persistence in infections and poor treatment outcome from conventional therapy. In this study, we introduce a gene targeting strategy using microbubble...
Functional hydrogel for modulating lipid droplets and neuroinflammation in head injury [0.03%]
用于调节脑外伤脂质滴和神经炎症的多功能水凝胶疗法
Feixiang Chen,Yvonne Shen,Yutong Shao et al.
Feixiang Chen et al.
Excessive inflammatory responses following traumatic brain injury (TBI) hinder tissue healing and impair long-term functional recovery. In addition to therapeutic strategies that directly target the core pathological mechanisms of TBI, biom...
Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers [0.03%]
可重构核酸纳米颗粒用于胞内疾病标志物的触发治疗性RNAi响应
Yelixza I Avila,Anh Ha,Morgan R Chandler et al.
Yelixza I Avila et al.
The therapeutic potential of RNA and DNA is evident from numerous formulations approved by the FDA in recent years, with formulations based on RNAi standing out as a successful example. The new class of medicines based on RNAi combines the ...
Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations [0.03%]
使用异氰化物连接技术进行细胞微环境的生物正交工程化
Ping Zhou,Lauren Brown,Christopher M Madl
Ping Zhou
Hydrogels are routinely used as scaffolds to mimic the extracellular matrix for tissue engineering. However, common strategies to covalently crosslink hydrogels employ reaction conditions with potential off-target biological reactivity. The...