Tumor-Targeted Multimodal Optical Imaging with Versatile Cadmium-Free Quantum Dots [0.03%]
多功能无镉量子点用于肿瘤特异性多模光学影像技術
Xiangyou Liu,Gary B Braun,Haizheng Zhong et al.
Xiangyou Liu et al.
The rapid development of fluorescence imaging technologies requires concurrent improvements in the performance of fluorescent probes. Quantum dots have been extensively used as an imaging probe in various research areas because of their inh...
Roozbeh Abedini-Nassab,Daniel Y Joh,Melissa Van Heest et al.
Roozbeh Abedini-Nassab et al.
We demonstrate magnetophoretic conductor tracks that can transport single magnetized beads and magnetically labeled single cells in a 3-dimensional time-varying magnetic field. The vertical field bias, in addition to the in-plane rotating f...
Chitosan-Alginate Microcapsules Provide Gastric Protection and Intestinal Release of ICAM-1-Targeting Nanocarriers, Enabling GI Targeting In Vivo [0.03%]
壳聚糖-海藻酸盐微胶囊提供胃保护并释放ICAM-1靶向纳米递送系统，可在体内实现胃肠道靶向给药
Rasa Ghaffarian,Edgar Pérez Herrero,Hyuntaek Oh et al.
Rasa Ghaffarian et al.
When administered intravenously, active targeting of drug nanocarriers (NCs) improves biodistribution and endocytosis. Targeting may also improve oral delivery of NCs to treat gastrointestinal (GI) pathologies or for systemic absoption. How...
Mechanisms and Microenvironment Investigation of Cellularized High Density Gradient Collagen Matrices via Densification [0.03%]
高密度梯度细胞化胶原矩阵的致密机制及微环境研究
Tyler Novak,Benjamin Seelbinder,Celina M Twitchell et al.
Tyler Novak et al.
Biological tissues and biomaterials are often defined by unique spatial gradients in physical properties that impart specialized function over hierarchical scales. The structure and organization of these materials forms continuous transitio...
Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi-peptide nanoparticles to tumour-associated macrophages and cancer cells [0.03%]
通过体内递送生物杂合RNAi-肽纳米颗粒对肿瘤相关巨噬细胞和癌细胞进行双重靶向免疫治疗
João Conde,Chenchen Bao,Yeqi Tan et al.
João Conde et al.
Lung cancer is associated with very poor prognosis and considered one of the leading causes of death worldwide. Here, we present highly potent and selective bio-hybrid RNAi-peptide nanoparticles that can induce specific and long-lasting gen...
Nanoparticle-Based Antivirulence Vaccine for the Management of Methicillin-Resistant Staphylococcus aureus Skin Infection [0.03%]
用于甲氧西林耐药金黄色葡萄球菌皮肤感染管理的抗毒力纳米颗粒疫苗
Fei Wang,Ronnie H Fang,Brian T Luk et al.
Fei Wang et al.
With the rising threat of antibiotic-resistant bacteria, vaccination is becoming an increasingly important strategy to prevent and manage bacterial infections. Made from deactivated bacterial toxins, toxoid vaccines are widely used in the c...
Hongyan Han,Hongyan Ning,Shanshan Liu et al.
Hongyan Han et al.
Functional vascularization is critical for the clinical regeneration of complex tissues such as kidney, liver or bone. The immobilization or delivery of growth factors has been explored to improve vascularization capacity of tissue engineer...
Exceptional Oxygen Sensing Properties of New Blue Light-Excitable Highly Luminescent Europium(III) and Gadolinium(III) Complexes [0.03%]
一种新型可被蓝光激发的高发光性能的Eu(Ⅲ)和Gd(Ⅲ)配合物及其优异的氧传感特性
Sergey M Borisov,Roland Fischer,Robert Saf et al.
Sergey M Borisov et al.
New europium(III) and gadolinium(III) complexes bearing 8-hydroxyphenalenone antenna combine efficient absorption in the blue part of the spectrum and strong emission in polymers at room temperature. The Eu(III) complexes show characteristi...
Highly scalable, closed-loop synthesis of drug-loaded, layer-by-layer nanoparticles [0.03%]
一种用于载药层层纳米粒子的高可扩展性、闭环合成方法
Santiago Correa,Ki Young Choi,Erik C Dreaden et al.
Santiago Correa et al.
Layer-by-layer (LbL) self-assembly is a versatile technique from which multicomponent and stimuli-responsive nanoscale drug carriers can be constructed. Despite the benefits of LbL assembly, the conventional synthetic approach for fabricati...
Modular and Versatile Spatial Functionalization of Tissue Engineering Scaffolds through Fiber-Initiated Controlled Radical Polymerization [0.03%]
基于纤维引发可控基团聚合反应的组织工程支架的空间功能化块化及多功能化
Rachael H Harrison,Joseph A M Steele,Robert Chapman et al.
Rachael H Harrison et al.
Native tissues are typically heterogeneous and hierarchically organized, and generating scaffolds that can mimic these properties is critical for tissue engineering applications. By uniquely combining controlled radical polymerization (CRP)...