Sulfated hydrogel matrices direct mitogenicity and maintenance of chondrocyte phenotype through activation of FGF signaling [0.03%]
硫酸化水凝胶矩阵通过激活FGF信号传导来指导增殖性和软骨细胞表型的维持
Ece Öztürk,Øystein Arlov,Seda Aksel et al.
Ece Öztürk et al.
Deciphering the roles of chemical and physical features of the extracellular matrix (ECM) is vital for developing biomimetic materials with desired cellular responses in regenerative medicine. Here, we demonstrate that sulfation of biopolym...
Haoyuan Huang,Jonathan F Lovell
Haoyuan Huang
Nanoscale materials have been explored extensively as agents for therapeutic and diagnostic (i.e. theranostic) applications. Research efforts have shifted from exploring new materials in vitro to designing materials that function in more re...
Dissociated and Reconstituted Cartilage Microparticles in Densified Collagen Induce Local hMSC Differentiation [0.03%]
解离和重构的软骨微粒在致密胶原中诱导局部人源间充质干细胞分化
Tyler Novak,Benjamin Seelbinder,Celina M Twitchell et al.
Tyler Novak et al.
Decellularized cartilage microparticles, and all associated native signals, are delivered to hMSC populations in a dense, type I collagen matrix. Hybrid usage of native tissue signals and the engineering control of collagen matrices show th...
Jeonghyun Kim,Philipp Gutruf,Antonio M Chiarelli et al.
Jeonghyun Kim et al.
Development of unconventional technologies for wireless collection, storage and analysis of quantitative, clinically relevant information on physiological status is of growing interest. Soft, biocompatible systems are widely regarded as imp...
Tracking and Quantification of Magnetically Labeled Stem Cells using Magnetic Resonance Imaging [0.03%]
磁共振成像技术追踪及量化磁标记干细胞的研究
Forrest Goodfellow,Gregory A Simchick,Luke J Mortensen et al.
Forrest Goodfellow et al.
Stem cell based therapies have critical impacts on treatments and cures of diseases such as neurodegenerative or cardiovascular disease. In vivo tracking of stem cells labeled with magnetic contrast agents is of particular interest and impo...
Abid Hussain,Ana T S Semeano,Susana I C J Palma et al.
Abid Hussain et al.
The cooperative assembly of biopolymers and small molecules can yield functional materials with precisely tunable properties. Here, the fabrication, characterization, and use of multicomponent hybrid gels as selective gas sensors are report...
A Cooperative Copper Metal-Organic Framework-Hydrogel System Improves Wound Healing in Diabetes [0.03%]
一种协同的铜金属有机骨架-水凝胶系统可改善糖尿病创面的愈合
Jisheng Xiao,Siyu Chen,Ji Yi et al.
Jisheng Xiao et al.
Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings that promote wound closure within a clinically relevant time frame. The use of copper ions has shown pr...
Identification of multiple dityrosine bonds in materials composed of the Drosophila protein Ultrabithorax [0.03%]
通过果蝇蛋白Ultrabithorax构成的材料鉴定多个二酪氨酸键
David W Howell,Shang-Pu Tsai,Kelly Churion et al.
David W Howell et al.
The recombinant protein Ultrabithorax (Ubx), a Drosophila melanogaster Hox transcription factor, self-assembles into biocompatible materials in vitro that are remarkably extensible and strong. Here, we demonstrate that the strength of Ubx m...
Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted In Vivo siRNA Delivery Vehicles [0.03%]
天然高密度脂蛋白的属性启发合成活性靶向体内siRNA递送载体
Kaylin M McMahon,Michael P Plebanek,C Shad Thaxton
Kaylin M McMahon
Efficient systemic administration of therapeutic short interfering RNA (siRNA) is challenging. High-density lipoproteins (HDL) are natural in vivo RNA delivery vehicles. Specifically, native HDLs: 1) Load single-stranded RNA; 2) Are anionic...
In Vivo Micro-CT Imaging of Human Mesenchymal Stem Cells Labeled with Gold-Poly-L-Lysine Nanocomplexes [0.03%]
金-聚赖氨酸纳米复合物标记的人骨髓间充质干细胞的活体micro-CT成像研究
Taeho Kim,Nohyun Lee,Dian R Arifin et al.
Taeho Kim et al.
Developing in vivo cell tracking is an important prerequisite for further development of cell-based therapy. So far, few computed tomography (CT) cell tracking studies have been described due to its notoriously low sensitivity and lack of e...