In Vivo Imaging of Composite Hydrogel Scaffold Degradation Using CEST MRI and Two-Color NIR Imaging [0.03%]
利用CEST磁共振成像和双色近红外成像在体成像复合水凝胶支架的降解情况
Wei Zhu,Chengyan Chu,Shreyas Kuddannaya et al.
Wei Zhu et al.
Hydrogel scaffolding of stem cells is a promising strategy to overcome initial cell loss and manipulate cell function post-transplantation. Matrix degradation is a requirement for downstream cell differentiation and functional tissue integr...
Multicore Liquid Perfluorocarbon-Loaded Multimodal Nanoparticles for Stable Ultrasound and 19F MRI Applied to In Vivo Cell Tracking [0.03%]
用于体内细胞追踪的稳定型超声与~(19)F-MRI多模态纳米颗粒
Olga Koshkina,Guillaume Lajoinie,Francesca Baldelli Bombelli et al.
Olga Koshkina et al.
Ultrasound is the most commonly used clinical imaging modality. However, in applications requiring cell-labeling, the large size and short active lifetime of ultrasound contrast agents limit their longitudinal use. Here, 100 nm radius, clin...
Modular multifunctional poly(ethylene glycol) hydrogels for stem cell differentiation [0.03%]
用于干细胞分化的模块化多功能聚（乙二醇）水凝胶
Anirudha Singh,Jianan Zhan,Zhaoyang Ye et al.
Anirudha Singh et al.
Synthetic polymers are employed to create highly defined microenvironments with controlled biochemical and biophysical properties for cell culture and tissue engineering. Chemical modification is required to input biological or chemical lig...
A Melanin-Based Natural Antioxidant Defense Nanosystem for Theranostic Application in Acute Kidney Injury [0.03%]
基于黑色素的天然抗氧化防御纳米系统在急性肾脏损伤诊疗中的应用研究
Tuanwei Sun,Dawei Jiang,Zachary T Rosenkrans et al.
Tuanwei Sun et al.
Acute kidney injury (AKI) is frequently associated with oxidative stress and causes high mortality annually in clinics. Nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for the treatment of AKI. Herein, a novel ...
Daeha Joung,Nicolas S Lavoie,Shuang-Zhuang Guo et al.
Daeha Joung et al.
Neural regeneration devices interface with the nervous system and can provide flexibility in material choice, implantation without the need for additional surgeries, and the ability to serve as guides augmented with physical, biological (e....
Hao Wan,Haotian Du,Feifei Wang et al.
Hao Wan et al.
In the past decade, noticeable progress has been achieved regarding fluorescence imaging in the second near-infrared (NIR-II) window. Fluorescence imaging in the NIR-II window demonstrates superiorities of deep tissue penetration and high s...
Self-assembled Hydrogel Fiber Bundles from Oppositely Charged Polyelectrolytes Mimic Micro-/nanoscale Hierarchy of Collagen [0.03%]
由带相反电荷的聚电解质自组装而成的水凝胶纤维束可模仿胶原蛋白的微/纳米结构层次
Shilpa Sant,Daniela F Coutinho,Akhilesh K Gaharwar et al.
Shilpa Sant et al.
Fiber bundles are present in many tissues throughout the body. In most cases, collagen subunits spontaneously self-assemble into a fibrilar structure that provides ductility to bone and constitutes the basis of muscle contraction. Translati...
A Facile and General Method for the Encapsulation of Different Types of Imaging Contrast Agents Within Micrometer-Sized Polymer Beads [0.03%]
一种包裹微米级聚合物珠中不同类型的成像对比剂的简便通用的方法
Meng-Yi Bai,Christine H Moran,Lei Zhang et al.
Meng-Yi Bai et al.
Polystyrene (PS) hollow beads with holes on the surfaces are employed as containers for quick loading and encapsulation of a variety of contrast enhancement agents: saline solutions for thermoacoustic tomography, iodinated organic compounds...
Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo using Layer-by-Layer Nanoparticles [0.03%]
用于体内血液系统恶性组织层状递送siRNA的纳米颗粒
Ki Young Choi,Santiago Correa,Jouha Min et al.
Ki Young Choi et al.
Using siRNA therapeutics to treat hematologic malignancies has been unsuccessful because blood cancer cells exhibit remarkable resistance to standard transfection methods. Herein we report the successful delivery of siRNA therapeutics with ...
Developing a Bright NIR-II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD-L1 [0.03%]
一种快速经肾脏排泄的高性能近红外二区荧光探针及其在PD-L1免疫检查点分子成像中的应用
Hao Wan,Huilong Ma,Shoujun Zhu et al.
Hao Wan et al.
Fluorescence imaging in the second near-infrared (NIR-II) window holds impressive advantages of enhanced penetration depth and improved signal-to-noise ratio. Bright NIR-II fluorophores with renal excretion ability and low tissue accumulati...