Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane [0.03%]
engineered纳米拓扑结构会在核膜中产生瞬态开口
Einollah Sarikhani,Vrund Patel,Zhi Li et al.
Einollah Sarikhani et al.
Materials with engineered nano-scale surface topographies, such as nanopillars, nanoneedles, and nanowires, mimic natural structures like viral spike proteins, enabling them to bypass biological barriers like the plasma membrane. These prop...
Lipopeptide Hydrogel Possesses Adjuvant-Like Properties for the Delivery of the GPC-3 Peptide-derived Antigen [0.03%]
脂肽水凝胶具有递送GPC-3肽抗原的佐剂类似物属性
Tess G Mathes,Uijin Kim,Keuna Jeon et al.
Tess G Mathes et al.
Peptide-based cancer vaccines are attractive as they can elicit antigen-specific cytotoxic T lymphocytes (CTLs) with minimal side effects. However, low immunogenic responses have delayed their translation to the clinic. Adjuvants, which are...
Engineering Novel DNA Nanoarchitectures for Targeted Drug Delivery and Aptamer mediated Apoptosis in Cancer Therapeutics [0.03%]
用于癌症治疗的靶向药物输送及适配体介导的凋亡工程新型DNA纳米结构
Abhisek Dwivedy,Dhyanesh Baskaran,Gaurav Sharma et al.
Abhisek Dwivedy et al.
The specific and potent delivery of anticancer drugs to targeted cancer stem cells (CSCs) remains a critical need to maximize on-target, on-tumor effects while minimizing on-target, off-tumor toxicities. Herein, we present our Designer DNA ...
Advanced hierarchical computational modeling-based rational development of platinum (II) nanocomplex to improve lung cancer therapy [0.03%]
基于高级层次计算模型的铂(II)纳米复合物的设计开发及其对肺癌治疗的改善作用
Haozhe Huang,Beihong Ji,Yixian Huang et al.
Haozhe Huang et al.
Cancer stem cells (CSCs), harboring stem cell-like properties involving self-renewal and aberrant differentiation potential, have been known to be one of the determining factors that contribute to therapeutic resistance and tumor recurrence...
Modular Anti-Counterfeit Tags Formed by Template-Assisted Self-Assembly of Plasmonic Nanocrystals and Authenticated by Machine Learning [0.03%]
基于模板辅助等离激元纳米粒子自组装的防伪标签及其机器学习鉴别方法
Maha Ibrar,Sheng-Yuan Huang,Zachery McCurtain et al.
Maha Ibrar et al.
Counterfeit goods are pervasive, being found in products as diverse as textiles and optical media to pharmaceuticals and sensitive electronics. Here, an anti-counterfeit platform is reported in which plasmonic nanoparticles (NPs) are used t...
Michelle Makhoul Mansour,Joshua J Maraj,Robert Jordan Pyron et al.
Michelle Makhoul Mansour et al.
Modeled after biological neurons, neuristors are emerging hardware that generate recurring voltage spikes in response to electrical stimulation. This type of excitability could enable transistor-free spiking neural networks for efficient si...
Exosomal Bupivacaine: Integrating Nerve Barrier Penetration Capability and Sustained Drug Release for Enhanced Potency in Peripheral Nerve Block and Reduced Toxicity [0.03%]
布比卡因exo囊泡：整合神经屏障穿透能力和持续药物释放以增强周围神经阻滞的效力并减少毒性
Yuhao Cai,Qi Li,Ursula Wesselmann et al.
Yuhao Cai et al.
Peripherally injected local anesthetics exhibit limited ability to penetrate peripheral nerve barriers (PNBs), which limits their effectiveness in peripheral nerve block and increases the risk of adverse effects. In this work, we demonstrat...
Engineered zwitterionic diblock copolymer-siRNA polyplexes provide highly effective treatment of triple-negative breast cancer in a 4T1 murine model [0.03%]
工程两性嵌段共聚物-siRNA多聚复合物可有效治疗三阴乳腺癌4T1小鼠模型中的肿瘤疾病
Taewon Jeon,Ritabrita Goswami,Harini Nagaraj et al.
Taewon Jeon et al.
Self-assembly of siRNA with a block copolymer featuring guanidinium and zwitterion functionalized blocks generates core-shell-like nanovectors that provide cytosolic access to siRNA and efficiently evade phagocytic clearance. The guanidiniu...
Wireless Peristaltic Pump for Transporting Viscous Fluids and Solid Cargos in Confined Spaces [0.03%]
用于在狭窄空间运输粘性流体和固体货物的无线蠕动泵
Saksham Sharma,Laura Caroline Jung,Nicholas Lee et al.
Saksham Sharma et al.
The transport of fluids and solids is a vital process inside the human body, facilitated by the wave-like motion in the lumen called peristalsis. However, peristalsis may be compromised due to tumor growth, resulting in difficulties in lume...
Sensing Mucus Physiological Property In Situ by Wireless Millimeter-Scale Soft Robots [0.03%]
通过无线毫米级软体机器人现场感知黏液生理特性
Boyang Xiao,Yilan Xu,Steven Edwards et al.
Boyang Xiao et al.
The physiological property of mucus is an important biomarker for monitoring the human health conditions and helping understand disease development, as mucus property such as viscosity is highly correlated with inflammation and other diseas...