Competition between exceptionally long-range alkyl sidechain ordering and backbone ordering in semiconducting polymers and its impact on electronic and optoelectronic properties [0.03%]
半导体聚合物中极长烷基侧链有序化和主链有序化的相互竞争及其对电子和光电性质的影响
Joshua H Carpenter,Masoud Ghasemi,Eliot Gann et al.
Joshua H Carpenter et al.
Intra- and intermolecular ordering greatly impact the electronic and optoelectronic properties of semiconducting polymers. Despite much prior efforts regarding molecular packing, the interrelationship between ordering of alkyl sidechains an...
In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS-Mediated Anticancer Therapy [0.03%]
用于增强ROS介导抗癌治疗的原位聚合中空介孔有机硅纳米反应器
Ling Li,Zhen Yang,Wenpei Fan et al.
Ling Li et al.
The combination of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic therapy (CDT) holds great promise for enhancing ROS-mediated cancer treatment. Herein, we reported an in situ polymerized hollow mesoporou...
Hybrid 3D Printing of Synthetic and Cell-Laden Bioinks for Shape Retaining Soft Tissue Grafts [0.03%]
用于形状保持的软组织移植的合成和含细胞生物墨水的混合3D打印技术
Sarah Van Belleghem,Leopoldo Torres Jr,Marco Santoro et al.
Sarah Van Belleghem et al.
Despite recent advances in clinical procedures, the repair of soft tissue remains a reconstructive challenge. Current technologies such as synthetic implants and dermal flap autografting result in inefficient shape retention and unpredictab...
Biodegradable fluorescent nanoparticles for endoscopic detection of colorectal carcinogenesis [0.03%]
用于结肠直肠癌内镜检测的可生物降解荧光纳米颗粒
Stephan Rogalla,Krzysztof Flisikowski,Dimitris Gorpas et al.
Stephan Rogalla et al.
Early and comprehensive endoscopic detection of colonic dysplasia - the most clinically significant precursor lesion to colorectal adenocarcinoma - provides an opportunity for timely, minimally-invasive intervention to prevent malignant tra...
Heterotargeted Nanococktail with Traceless Linkers for Eradicating Cancer [0.03%]
用于根除癌症的无痕链接异靶标纳米鸡尾酒策略
Binglin Sui,Chen Cheng,Mingming Wang et al.
Binglin Sui et al.
Clinical application of drug cocktails for cancer therapy is limited by their severe systemic toxicity. To solve a catch-22 dilemma between safety and efficacy for drug cocktails, a hetero-targeted nano-cocktail (PPPDMA) with traceless link...
A Tumor-on-a-Chip System with Bioprinted Blood and Lymphatic Vessel Pair [0.03%]
具有生物打印的血管和淋巴管对的芯片肿瘤系统
Xia Cao,Ramla Ashfaq,Feng Cheng et al.
Xia Cao et al.
Current in vitro anti-tumor drug screening strategies are insufficiently portrayed lacking true perfusion and draining microcirculation systems, which may post significant limitation in reproducing the transport kinetics of cancer therapeut...
Covalently adaptable elastin-like protein - hyaluronic acid (ELP - HA) hybrid hydrogels with secondary thermoresponsive crosslinking for injectable stem cell delivery [0.03%]
具有次级热响应交联的共价可调节弹性蛋白样蛋白-透明质酸(ELP-HA)水凝胶用于注射干细胞递送
Huiyuan Wang,Danqing Zhu,Alexandra Paul et al.
Huiyuan Wang et al.
Shear-thinning, self-healing hydrogels are promising vehicles for therapeutic cargo delivery due to their ability to be injected using minimally invasive surgical procedures. We present an injectable hydrogel using a novel combination of dy...
Xianhu Sun,Wenhui Zhu,Dongxiang Wu et al.
Xianhu Sun et al.
A fundamental knowledge of the unidirectional growth mechanisms is required for precise control on size, shape, and thereby functionalities of nanostructures. The oxidation of many metals results in oxide nanowire growth with a bicrystal gr...
Porous Silicon Nanoparticles Embedded in Poly(lactic- co-glycolic acid) Nanofiber Scaffolds Deliver Neurotrophic Payloads to Enhance Neuronal Growth [0.03%]
嵌入聚乳酸-共-甘醇酸纳米纤维支架的多孔硅纳米颗粒输送神经营养有效负载以增强神经元生长
Jonathan M Zuidema,Courtney M Dumont,Joanna Wang et al.
Jonathan M Zuidema et al.
Scaffolds made from biocompatible polymers provide physical cues to direct the extension of neurites and to encourage repair of damaged nerves. The inclusion of neurotrophic payloads in these scaffolds can substantially enhance regrowth and...
Self-Assembly of Therapeutic Peptide into Stimuli-Responsive Clustered Nanohybrids for Cancer-Targeted Therapy [0.03%]
治疗性肽自我组装成刺激响应型聚集纳米杂化物用于癌症靶向治疗
Wangxiao He,Simeng Wang,Jin Yan et al.
Wangxiao He et al.
Clinical translation of therapeutic peptides, particularly those targeting intracellular protein-protein interactions (PPIs), has been hampered by their inefficacious cellular internalization in diseased tissue. Therapeutic peptides enginee...