Rapidly-customizable, scalable 3D-printed wireless optogenetic probes for versatile applications in neuroscience [0.03%]
一种用于神经科学研究的无线光遗传探针的快速定制和规模化3D打印方法
Juhyun Lee,Kyle E Parker,Chinatsu Kawakami et al.
Juhyun Lee et al.
Optogenetics is an advanced neuroscience technique that enables the dissection of neural circuitry with high spatiotemporal precision. Recent advances in materials and microfabrication techniques have enabled minimally invasive and biocompa...
Bioprinted Injectable Hierarchically Porous Gelatin Methacryloyl Hydrogel Constructs with Shape-Memory Properties [0.03%]
具有形状记忆性能的生物打印可注射分层多孔甲基丙烯酰化明胶水凝胶构建体
Guoliang Ying,Nan Jiang,Carolina Parra et al.
Guoliang Ying et al.
Direct injection of cell-laden hydrogels shows high potentials in tissue regeneration for translational therapy. The traditional cell-laden hydrogels are often used as bulk space fillers to tissue defects after injection, likely limiting th...
Reversible Functionalization of Clickable Polyacrylamide Gels with Protein and Graft Copolymers [0.03%]
可用于蛋白质和接枝共聚物的可逆修饰的聚丙烯酰胺凝胶
Hector D Neira,Shaheen Jeeawoody,Amy E Herr
Hector D Neira
Modular strategies to fabricate gels with tailorable chemical functionalities are relevant to applications spanning from biomedicine to analytical chemistry. Here, the properties of clickable poly(acrylamide-co-propargyl acrylate) (pAPA) hy...
Injectable Drug-Releasing Microporous Annealed Particle Scaffolds for Treating Myocardial Infarction [0.03%]
用于治疗心肌梗死的可注射药物缓释微孔烧结支架
Jun Fang,Jaekyung Koh,Qizhi Fang et al.
Jun Fang et al.
Intramyocardial injection of hydrogels offers great potential for treating myocardial infarction (MI) in a minimally invasive manner. However, traditional bulk hydrogels generally lack microporous structures to support rapid tissue ingrowth...
From arteries to capillaries: approaches to engineering human vasculature [0.03%]
从动脉到毛细血管：工程化人体血管的方法
Sharon Fleischer,Daniel Naveed Tavakol,Gordana Vunjak-Novakovic
Sharon Fleischer
From micro-scaled capillaries to millimeter-sized arteries and veins, human vasculature spans multiple scales and cell types. The convergence of bioengineering, materials science, and stem cell biology has enabled tissue engineers to recrea...
Macrophage-Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention [0.03%]
巨噬细胞介导的肿瘤细胞吞噬作用：纳米医学干预的机会
Xuefei Zhou,Xiangrui Liu,Leaf Huang
Xuefei Zhou
Macrophages are one of the most abundant non-malignant cells in the tumor microenvironment, playing critical roles in mediating tumor immunity. As important innate immune cells, macrophages possess the potential to engulf tumor cells and pr...
Organoid Polymer Functionality and Mode of Klebsiella Pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells [0.03%]
类器官聚合物功能和肺炎克雷伯氏菌膜抗原呈递模式调节年轻和老年B细胞体外生发中心表观遗传学
Pamela L Graney,Kristine Lai,Sarah Post et al.
Pamela L Graney et al.
Antibiotic-resistant bacteria are a major global health threat that continues to rise due to a lack of effective vaccines. Of concern are Klebsiella pneumoniae that fail to induce in vivo germinal center B cell responses, which facilitate a...
Obesity-associated Adipose Stromal Cells Promote Breast Cancer Invasion Through Direct Cell Contact and ECM Remodeling [0.03%]
脂肪干细胞通过直接细胞接触和重塑细胞外基质促进乳腺癌侵袭性发展
Lu Ling,Jeffrey A Mulligan,Yunxin Ouyang et al.
Lu Ling et al.
Obesity increases the risk and worsens the prognosis for breast cancer due, in part, to altered adipose stromal cell (ASC) behavior. Whether ASCs from obese individuals increase migration of breast cancer cells relative to their lean counte...
Leveraging the modularity of biomaterial carriers to tune immune responses [0.03%]
利用生物材料载体的模块化调节免疫反应
Shannon J Tsai,Sheneil K Black,Christopher M Jewell
Shannon J Tsai
Biomaterial carriers offer modular features to control the delivery and presentation of vaccines and immunotherapies. This tunability is a distinct capability of biomaterials. Understanding how tunable material features impact immune respon...
Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model [0.03%]
三维血管化肿瘤模型中内皮细胞对药物转运的调节作用
Kristina Haase,Giovanni S Offeddu,Mark R Gillrie et al.
Kristina Haase et al.
Drug discovery and efficacy in cancer treatments are limited by the inability of pre-clinical models to predict successful outcomes in humans. Limitations remain partly due to their lack of a physiologic tumor microenvironment (TME), which ...