Neuro-Nano Interfaces: Utilizing Nano-Coatings and Nanoparticles to Enable Next-Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation [0.03%]
神经纳米接口：利用纳米涂层和纳米颗粒实现下一代电生理记录、神经刺激和生化调节
Ashlyn T Young,Neil Cornwell,Michael A Daniele
Ashlyn T Young
Neural interfaces provide a window into the workings of the nervous system-enabling both biosignal recording and modulation. Traditionally, neural interfaces have been restricted to implanted electrodes to record or modulate electrical acti...
Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments [0.03%]
用于细胞培养和调控组装组织微环境的微凝胶的设计
Alexander S Caldwell,Brian A Aguado,Kristi S Anseth
Alexander S Caldwell
Micron-sized hydrogels, termed microgels, are emerging as multifunctional platforms that can recapitulate tissue heterogeneity in engineered cell microenvironments. The microgels can function as either individual cell culture units or can b...
Silver Nanofilament Formation Dynamics in a Polymer-Ionic Liquid Thin Film by Direct-Write [0.03%]
导电高分子离子液体复合薄膜的直接书写及银纳米丝形成动力学研究
Zhongmou Chao,Kutay B Sezginel,Ke Xu et al.
Zhongmou Chao et al.
Silver nanofilament formation dynamics are reported for an ionic liquid (IL)-filled solid polymer electrolyte prepared by a direct-write process using a conductive atomic force microscope (C-AFM). Filaments are electrochemically formed at h...
Hybrid Graphene-Gold Nanoparticle-based Nucleic Acid Conjugates for Cancer-Specific Multimodal Imaging and Combined Therapeutics [0.03%]
基于杂化石墨烯-金纳米粒子的核酸缀合物用于癌症特异性多模式成像和综合治疗研究
Letao Yang,Tae-Hyung Kim,Hyeon-Yeol Cho et al.
Letao Yang et al.
Nanoparticle-based nucleic acid conjugates (NP-NACs) hold great promise for theragnostic (diagnostic and therapeutic) applications. However, several limitations have hindered the realization of their full potential in the clinical treatment...
Amanda X Chen,Arnav Chhabra,H-H Greco Song et al.
Amanda X Chen et al.
Engineered tissue models comprise a variety of multiplexed ensembles in which combinations of epithelial, stromal, and immune cells give rise to physiologic function. Engineering spatiotemporal control of cell-cell and cell-matrix interacti...
Macrophage immunomodulation through new polymers that recapitulate functional effects of itaconate as a power house of innate immunity [0.03%]
通过新型聚合物模拟ITA对先天免疫起重要调控作用的巨噬细胞极化重编程研究
L Davenport Huyer,S Mandla,Y Wang et al.
L Davenport Huyer et al.
Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. We developed a library of polyester materials that incorporate ITA into polymer bac...
siRNA nanoparticle suppresses drug-resistant gene and prolongs survival in an orthotopic glioblastoma xenograft mouse model [0.03%]
siRNA纳米颗粒抑制药物抗性基因并延长异种移植胶质母细胞瘤小鼠模型的存活时间
Kui Wang,Forrest M Kievit,Peter A Chiarelli et al.
Kui Wang et al.
Temozolomide (TMZ) is the standard of care chemotherapy drug for treating glioblastomas (GBMs), the most aggressive cancer that affects people of all ages. However, its therapeutic efficacy is limited by the drug resistance mediated by a DN...
Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion [0.03%]
用于有效预防术后粘连的生物可降解两性离子膏状凝胶
Ershuai Zhang,Jianhai Yang,Ke Wang et al.
Ershuai Zhang et al.
Postoperative peritoneal adhesions were frequent complications for almost any types of abdominal and pelvic surgery. This led to numerous medical problems and huge financial burden to the patients. Current anti-adhesion strategies focused m...
Irsalan Cockerill,Carmine Wang See,Marcus L Young et al.
Irsalan Cockerill et al.
Cardiovascular stents are life-saving devices and one of the top 10 medical breakthroughs of the 21st century. Decades of research and clinical trials have taught us about the effects of material (metal or polymer), design (geometry, strut ...
Polymer Electrochromism Driven by Metabolic Activity Facilitates Rapid and Facile Bacterial Detection and Susceptibility Evaluation [0.03%]
基于代谢活性驱动聚合物电致色效应实现快速简易的细菌检测及药敏评估
Jiayingzi Wu,Yifan Zhu,Liyan You et al.
Jiayingzi Wu et al.
The electrochromism of a water-soluble naturally oxidized electrochromic polymer, ox-PPE, is harnessed for rapid and facile bacterial detection, discrimination, and susceptibility testing. The ox-PPE solution shows distinct colorimetric and...