Aggregation-Enhanced Photoluminescence and Photoacoustics of Atomically Precise Gold Nanoclusters in Lipid Nanodiscs (NANO2) [0.03%]
脂质纳米盘中金原子精确定量纳米团簇的聚集增强型光致发光和光声成像（NANO2）
Armin Tahmasbi Rad,Yue Bao,Hyun-Sook Jang et al.
Armin Tahmasbi Rad et al.
The authors designed a structurally stable nano-in-nano (NANO2) system highly capable of bioimaging via an aggregation-enhanced NIR excited emission and photoacoustic response achieved based on atomically precise gold nanoclusters protected...
Zhikang Li,Shiming Zhang,Yihang Chen et al.
Zhikang Li et al.
Gelatin methacryloyl (GelMA) is a widely used hydrogel with skin-derived gelatin acting as the main constituent. However, GelMA has not been used in the development of wearable biosensors, which are emerging devices that enable personalized...
A Combination of Cowpea Mosaic Virus and Immune Checkpoint Therapy Synergistically Improves Therapeutic Efficacy in Three Tumor Models [0.03%]
Cowpea mosaic virus与免疫检查点疗法联合治疗在三种肿瘤模型中的协同增效作用研究
Chao Wang,Nicole F Steinmetz
Chao Wang
Immune checkpoint therapy (ICT) has the potential to treat cancer by removing the immunosuppressive brakes on T cell activity. However, ICT benefits only a subset of patients because most tumors are "cold", with limited pre-infiltration of ...
The Antitumor Efficacy of CpG Oligonucleotides is Improved by Encapsulation in Plant Virus-Like Particles [0.03%]
植物病毒样颗粒囊封可增强CpG寡核苷酸的抗肿瘤疗效
Hui Cai,Sourabh Shukla,Nicole F Steinmetz
Hui Cai
Oligodeoxynucleotides (ODNs) with CpG motifs have potent immunostimulatory effects on many subsets of immune cells. For example, Class B CpG-ODNs, such as ODN1826 induce the phagocytic activity of macrophages by activating the Toll-like rec...
A Wirelessly Controlled Smart Bandage with 3D-Printed Miniaturized Needle Arrays [0.03%]
一种无线控制的智能绷带，带有3D打印微型针阵列
Hossein Derakhshandeh,Fariba Aghabaglou,Alec McCarthy et al.
Hossein Derakhshandeh et al.
Chronic wounds are one of the most devastating complications of diabetes and are the leading cause of nontraumatic limb amputation. Despite the progress in identifying factors and promising in vitro results for the treatment of chronic woun...
Induction of 4D spatiotemporal geometric transformations in high cell density tissues via shape changing hydrogels [0.03%]
基于形状变化水凝胶的高细胞密度组织中4D时空几何变换的诱导
Yu Bin Lee,Oju Jeon,Sang Jin Lee et al.
Yu Bin Lee et al.
Developing and healing tissues begin as a cellular condensation. Spatiotemporal changes in tissue geometry, transformations in the spatial distribution of the cells and extracellular matrix, are essential for its evolution into a functional...
Margherita Mencattelli,Abhijit Mondal,Roberta Miale et al.
Margherita Mencattelli et al.
Like ready-to-wear clothing, medical devices come in a fixed set of sizes. While this may accommodate a large fraction of the patient population, others must either experience suboptimal results due to poor sizing or must do without the dev...
Neuromodulation Management of Chronic Neuropathic Pain in The Central Nervous system [0.03%]
中枢神经系统慢性神经病理性疼痛的神经调控治疗
Kai Yu,Xiaodan Niu,Bin He
Kai Yu
Neuromodulation is becoming one of the clinical tools for treating chronic neuropathic pain by transmitting controlled physical energy to the pre-identified neural targets in the central nervous system. Its nature of drug-free, non-addictiv...
Surface engineered polymersomes for enhanced modulation of dendritic cells during cardiovascular immunotherapy [0.03%]
用于心血管免疫治疗时增强调节树突状细胞的表面工程聚合物囊泡
Sijia Yi,Xiaohan Zhang,Hussain Sangji et al.
Sijia Yi et al.
The principle cause of cardiovascular disease (CVD) is atherosclerosis, a chronic inflammatory condition characterized by immunologically complex fatty lesions within the intima of arterial vessel walls. Dendritic cells (DCs) are key regula...
3D Hybrid Nanofiber Aerogels Combining with Nanoparticles Made of a Biocleavable and Targeting Polycation and MiR-26a for Bone Repair [0.03%]
一种新型生物可降解肽纳米纤维气凝胶用于miRNA传递及促进骨再生修复
Ruiquan Li,Hongjun Wang,Johnson V John et al.
Ruiquan Li et al.
The healing of large bone defects represents a clinical challenge, often requiring some form of grafting. Three-dimensional (3D) nanofiber aerogels could be a promising bone graft due to their biomimetic morphology and controlled porous str...