Efficient Drug Delivery into Skin Using a Biphasic Dissolvable Microneedle Patch with Water-Insoluble Backing [0.03%]
使用双相可溶解背衬的微针贴片有效将药物输送到皮肤中
Song Li,Dengning Xia,Mark R Prausnitz
Song Li
Dissolvable microneedle patches (MNPs) enable simplified delivery of therapeutics via the skin. However, most dissolvable MNPs do not deliver their full drug loading to the skin because only some of the drug is localized in the microneedles...
Coating of a Novel Antimicrobial Nanoparticle with a Macrophage Membrane for the Selective Entry into Infected Macrophages and Killing of Intracellular Staphylococci [0.03%]
用巨噬细胞膜包被新型抗微生物纳米粒子，选择性进入感染的巨噬细胞并杀死胞内葡萄球菌
Yuanfeng Li,Yong Liu,Yijin Ren et al.
Yuanfeng Li et al.
Internalization of Staphylococcus aureus by macrophages can inactivate bacterial killing mechanisms, allowing intracellular residence and dissemination of infection. Concurrently, these staphylococci can evade antibiotics that are frequentl...
Ultra-selective carbon nanotubes for photoacoustic imaging of inflamed atherosclerotic plaques [0.03%]
用于炎症性动脉粥样硬化斑块光声成像的超选择性碳纳米管
Mahsa Gifani,Devon J Eddins,Hisanori Kosuge et al.
Mahsa Gifani et al.
Disruption of vulnerable atherosclerotic plaques often leads to myocardial infarction and stroke, the leading causes of morbidity and mortality in the United States. A diagnostic method that detects high-risk atherosclerotic plaques at earl...
So-Yoon Yang,Vitor Sencadas,Siheng Sean You et al.
So-Yoon Yang et al.
Implantable and ingestible biomedical electronic devices can be useful tools for detecting physiological and pathophysiological signals, and providing treatments that cannot be done externally. However, one major challenge in the developmen...
Shicheng Ye,Jochem W B Boeter,Marko Mihajlovic et al.
Shicheng Ye et al.
End-stage liver diseases are an increasing health burden, and liver transplantations are currently the only curative treatment option. Due to a lack of donor livers, alternative treatments are urgently needed. Human liver organoids are very...
Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy [0.03%]
用于增强全身siRNA递送的光交联生物还原型聚meric纳米颗粒作为癌症治疗方案
Johan Karlsson,Stephany Y Tzeng,Shayan Hemmati et al.
Johan Karlsson et al.
Clinical translation of polymer-based nanocarriers for systemic delivery of RNA has been limited due to poor colloidal stability in the blood stream and intracellular delivery of the RNA to the cytosol. To address these limitations, this st...
Boning Qiu,Nils Bessler,Kianti Figler et al.
Boning Qiu et al.
To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro ...
Maximizing Chiral Perturbation on Thermally Activated Delayed Fluorescence Emitters and Elaboration of the First Top-Emission Circularly Polarized OLED [0.03%]
通过热激活延迟荧光发射体最大化手性扰动并研发首个顶部发光圆偏振OLED
Lucas Frédéric,Alaric Desmarchelier,Romain Plais et al.
Lucas Frédéric et al.
Molecular designs merging circularly polarized luminescence (CPL) and thermally activated delayed fluorescence (CP-TADF) using the concept of chiral perturbation appeared recently as a cornerstone for the development of efficient CP-organic...
Heparin Microislands in Microporous Annealed Particle Scaffolds for Accelerated Diabetic Wound Healing [0.03%]
用于加速糖尿病伤口愈合的在微孔退火粒子支架中的肝素微岛结构
Lauren Pruett,Christian Jenkins,Neharika Singh et al.
Lauren Pruett et al.
Mimicking growth factor-ECM interactions for promoting cell migration is a powerful technique to improve tissue integration with biomaterial scaffolds for the regeneration of damaged tissues. This has been attempted by scaffold-mediated con...
Poly(catecholamine) coated CsPbBr3 perovskite microlasers: lasing in water and biofunctionalization [0.03%]
聚（邻苯二胺）涂层的CsPbBr3钙钛矿微激光器：水中的激光及生物功能化
Sangyeon Cho,Seok Hyun Yun
Sangyeon Cho
Lead halide perovskite (LHP) is a promising material for various optoelectronic applications. Surface coating on particles is a common strategy to improve their functionality and environmental stability, but LHP is not amenable to most coat...