Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal-Organic Frameworks [0.03%]
基于金属有机框架材料的mRNA包封及基因传递递送策略研究
Harrison Douglas Lawson,Huy Hoang Nguyen,Keng-Jung Lee et al.
Harrison Douglas Lawson et al.
Metal-organic frameworks (MOFs) have evolved from uses in catalysis and gas storage to exciting applications in biomedicine, particularly in drug delivery. Initially, MOFs are primarily used to deliver small molecules, recent innovations ha...
Resonance Energy Transfer-Driven Photothermal Nanoagent Enables Melanoma Ablation Under Low-Power Near-Infrared Irradiation [0.03%]
基于共振能量转移的光热治疗剂用于低功率近红外照射下的黑色素瘤消融
Prem Singh,Constanze Raitmayr,Syed Zaki Husain Rizvi et al.
Prem Singh et al.
Photothermal therapy (PTT) utilizes near-infrared (NIR) light to activate photothermal agents, enabling localized tumor ablation. However, conventional agents require high laser power densities to reach therapeutic temperatures, exceeding t...
DNA Helix Bundle-Encoded Multi-Bit Information Readout by Sapphire-Supported Nanopores [0.03%]
蓝宝石支撑纳米孔读取DNA螺旋束编码的多比特信息
Pengkun Xia,Deeksha Satyabola,Nimarpreet Kaur Bamrah et al.
Pengkun Xia et al.
The increasing demand for high-capacity data storage continues to drive innovation in memory technologies. DNA has emerged as a promising high-density data storage medium. Data storage using DNA nanostructures is compatible with complex dat...
Structurally Engineered Ferrous Metal-Organic Framework as a Chemodynamic Therapy Nanoagent for Concurrent Hydroxyl Radical and Singlet Oxygen Generation [0.03%]
结构工程铁基金属有机骨架协同生成羟基和单线态氧的化学动力学治疗纳米药物
Chao Wang,Kongbrailatpam Shitaljit Sharma,Yoon Tae Goo et al.
Chao Wang et al.
Chemodynamic therapy (CDT) is an emerging cancer treatment that employs transition metal-based nanoagents to catalyze the conversion of elevated intracellular hydrogen peroxide in malignant cells into cytotoxic hydroxyl radicals (•OH) via ...
RNA-Micelles as Self-Assembling Structures for Efficient Co-Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis [0.03%]
用于协同递送治疗结直肠癌肺转移的siRNA和核苷类似物的自组装RNA胶束
Kai Jin,Piotr Rychahou,Daniel W Binzel et al.
Kai Jin et al.
SiRNA has been widely studied in cancer gene silencing over the last 25 years. However, few siRNA-based therapeutics have been approved by the FDA. An RNA-micelle platform provides a powerful therapeutic tool through simple one-step, high-y...
Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA-Based Therapeutics [0.03%]
控制基于RNA的治疗中脂质纳米颗粒载药异质性
Turash Haque Pial,Sixuan Li,Jinghan Lin et al.
Turash Haque Pial et al.
Lipid nanoparticles (LNPs) are a leading platform for nucleic acid delivery, yet conventional assembly by mixing lipids with RNA yields particles with heterogeneous, bimodal payload distribution. Our transfection experiments demonstrate tha...
Emerging 2D Materials and Their Hybrid Nanostructures for Label-Free Optical Biosensing: Recent Progress and Outlook [0.03%]
用于无标签光学生物传感器的新型二维材料及其杂化纳米结构：近期进展和展望
Xinyi Li,Yonghao Fu,Yuehe Lin et al.
Xinyi Li et al.
The increasing demand for rapid detection and remote monitoring with high sensitivity and selectivity has driven the development of label-free optical biosensors based on 2D materials (2DMs). Owing to their high surface-to-volume ratio and ...
Noninvasive Assessment of Protease Activity in Osteosarcoma via Click Chemistry-Mediated Enrichment of Extracellular Vesicles [0.03%]
基于点击化学介导的细胞外囊泡富集技术评估骨肉瘤蛋白酶活性
You-Ren Ji,Junseok Lee,Hyoyong Kim et al.
You-Ren Ji et al.
Osteosarcoma (OS), the most common bone cancer in children, is characterized by aggressive tumors and subclinical metastasis. Metastasis significantly impacts OS patient survival rate, highlighting the need for frequent assessment of diseas...
Xiujun Fan,Songyue Chen,Farid Manshaii et al.
Xiujun Fan et al.
The development of soft mechanocaloric materials is becoming increasingly important due to the growing demand for energy-efficient and environmentally friendly thermoregulation solutions. Here the mechanocaloric effects in soft materials, w...
MPI-Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers [0.03%]
基于MPI引导的前列腺癌光热治疗的磁诊疗纳米花及其干细胞递送研究
Behnaz Ghaemi,Ana Rosu,Shreyas Kuddannaya et al.
Behnaz Ghaemi et al.
The efficacy of photothermal therapy (PTT) of cancer critically depends on widespread nanoparticle (NP) distribution and retention within the tumor. However, intratumoral (i.t.) injection of naked NPs may result in poor dispersion and backf...