Functional hydrogel for modulating lipid droplets and neuroinflammation in head injury [0.03%]
用于调节脑外伤脂质滴和神经炎症的多功能水凝胶疗法
Feixiang Chen,Yvonne Shen,Yutong Shao et al.
Feixiang Chen et al.
Excessive inflammatory responses following traumatic brain injury (TBI) hinder tissue healing and impair long-term functional recovery. In addition to therapeutic strategies that directly target the core pathological mechanisms of TBI, biom...
Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers [0.03%]
可重构核酸纳米颗粒用于胞内疾病标志物的触发治疗性RNAi响应
Yelixza I Avila,Anh Ha,Morgan R Chandler et al.
Yelixza I Avila et al.
The therapeutic potential of RNA and DNA is evident from numerous formulations approved by the FDA in recent years, with formulations based on RNAi standing out as a successful example. The new class of medicines based on RNAi combines the ...
Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations [0.03%]
使用异氰化物连接技术进行细胞微环境的生物正交工程化
Ping Zhou,Lauren Brown,Christopher M Madl
Ping Zhou
Hydrogels are routinely used as scaffolds to mimic the extracellular matrix for tissue engineering. However, common strategies to covalently crosslink hydrogels employ reaction conditions with potential off-target biological reactivity. The...
Anisotropic liquid crystalline hydrogels direct 2D and 3D myoblast alignment [0.03%]
各向异性液晶水凝胶可指导肌母细胞的二维和三维排列方向
Nathaniel P Skillin,Lorin Danielsen,Bruce E Kirkpatrick et al.
Nathaniel P Skillin et al.
Tissue development and regeneration are governed by processes that span subcellular signaling, cell-cell interactions, and the integrated mechanical properties of cellular collectives with their extracellular matrix. Synthetic biomaterials ...
Development of Nanocarrier-Based Oral Pegfilgrastim Formulations for Mitigating Hematopoietic Acute Radiation Syndrome [0.03%]
开发基于纳米载体的口服聚乙二醇化曲司库单抗剂型以减轻造血急性和辐射综合征
Yuefei Zhu,Daniel Naveed Tavakol,Huaxi Wang et al.
Yuefei Zhu et al.
The increasing risks of ionizing radiation from deep space travel and nuclear accidents necessitate the development of effective countermeasures. Acute radiation syndrome (ARS), particularly hematopoietic ARS (H-ARS), leads to life-threaten...
Rapid and Controllable Multilayer Cell Sheet Assembly via Biodegradable Nanochannel Membranes [0.03%]
利用可生物降解纳米通道膜快速可控地组装多层细胞片
Letao Yang,Christopher Rathnam,Yannan Hou et al.
Letao Yang et al.
The ability to precisely arrange and control the assembly of diverse cell types into intricate three-dimensional (3D) structures remains a critical challenge in tissue engineering. Herein, we describe a versatile and programmable 3D cell sh...
Functionalized Annealed Microgels for Spatial Control of Osteogenic and Chondrogenic Differentiation [0.03%]
功能化退火微凝胶的空间控制成骨和软骨分化
Jeremy M Lowen,Erika E Wheeler,Nathan K Shimamoto et al.
Jeremy M Lowen et al.
The biophysical heterogeneity of the bone-cartilage interface requires complex materials to mimic differences in bone density, extracellular matrix composition, and mineralization. Biomaterial approaches to repair osteochondral tissue typic...
The conformal, high-density SpineWrap microelectrode array for focal stimulation and selective muscle recruitment [0.03%]
用于聚焦刺激和选择性募集肌肉的共形高密度SpineWrap微电极阵列
Samantha M Russman,Rhea Montgomery-Walsh,Ritwik Vatsyayan et al.
Samantha M Russman et al.
Epidural electrical stimulation (EES) of the spinal cord is widely applied for pain management and has garnered considerable interest as a possible route to functional restoration after spinal cord injury. Currently, EES employs bulky, non-...
Local administration of lipid-silica nanohybrid-carried forskolin modulates thermogenesis in human adipocytes and impedes weight gain in mice [0.03%]
局部给药的载有肉豆蔻呋喃的脂质-硅纳米杂化体可调节人脂肪细胞中的产热并抑制小鼠体重增加
David Zhang,Lien Tang,Tyler Hipple et al.
David Zhang et al.
Despite encouraging outcomes of the eight FDA approved drugs in lessening obesity burden, they have been associated with side effects caused by the lack of direct action on the adipose tissue. Therefore, we report a nanomedicine that promot...
A Self-Renewing Biomimetic Skeletal Muscle Construct Engineered using Induced Myogenic Progenitor Cells [0.03%]
利用诱导肌源性干细胞工程化自更新仿生骨骼肌肉模型
Inseon Kim,Seunghun S Lee,Adhideb Ghosh et al.
Inseon Kim et al.
Skeletal muscle represents a highly organized tissue that primarily regenerates by myogenic stem cells. Mimicking an in vitro skeletal muscle differentiation program that contains self-renewing muscle stem cells and aligned myotubes is cons...