Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants [0.03%]
环糊精调控I型胶原蛋白的自组装以构建仿生角膜移植物
Shoumyo Majumdar,Xiaokun Wang,Sven D Sommerfeld et al.
Shoumyo Majumdar et al.
Collagen-rich tissues in the cornea exhibit unique and highly organized extracellular matrix ultrastructures, which contribute to its high load-bearing capacity and light transmittance. Corneal collagen fibrils are controlled during develop...
Debadrita Paria,Annalisa Convertino,Piyush Raj et al.
Debadrita Paria et al.
Nanotechnology has provided tools for next generation biomedical devices which rely on nanostructure interfaces with living cells. In vitro biomimetic structures have enabled observation of cell response to various mechanical and chemical c...
Developing Acid-Responsive Glyco-Nanoplatform Based Vaccines for Enhanced Cytotoxic T-lymphocyte Responses Against Cancer and SARS-CoV-2 [0.03%]
基于糖纳米平台的酸响应性癌症和SARS-CoV-2疫苗，可增强细胞毒性T淋巴细胞的反应
Yanan Gao,Qingyu Zhao,Huiling Dong et al.
Yanan Gao et al.
Cytotoxic T-lymphocytes (CTLs) are central for eliciting protective immunity against malignancies and infectious diseases. Here, for the first time, partially oxidized acetalated dextran nanoparticles (Ox-AcDEX NPs) with an average diameter...
A Broad-Spectrum Antimicrobial and Antiviral Membrane Inactivates SARS-CoV-2 in Minutes [0.03%]
一种广谱抗菌抗病毒膜可在几分钟内使SARS-CoV-2失活
Qingsheng Liu,Yidan Zhang,Wanjun Liu et al.
Qingsheng Liu et al.
SARS-CoV-2, the virus that caused the COVID-19 pandemic, can remain viable and infectious on surfaces for days, posing a potential risk for fomite transmission. Liquid-based disinfectants, such as chlorine-based ones, have played an indispe...
Yu Tao,Hon Fai Chan,Bingyang Shi et al.
Yu Tao et al.
Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal and spatial control. Great progress has been achieved in the development of novel light-driven drug...
Nanogel-facilitated Protein Intracellular Specific Degradation through Trim-Away [0.03%]
纳米凝胶通过Trim-Away实现蛋白质细胞内特异性降解
Binglin Sui,Mingming Wang,Chen Cheng et al.
Binglin Sui et al.
Recently discovered "Trim-Away" mechanism opens a new window for fast and selective degradation of endogenous proteins. However, the in vivo and clinical application of this approach is stuck by the requirement of special skills and equipme...
Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction [0.03%]
颅面重建的硬组织、软组织及硬软复合组织的术中生物打印技术
Kazim K Moncal,Hemanth Gudapati,Kevin P Godzik et al.
Kazim K Moncal et al.
Reconstruction of complex craniomaxillofacial (CMF) defects is challenging due to the highly organized layering of multiple tissue types. Such compartmentalization necessitates the precise and effective use of cells and other biologics to r...
Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury [0.03%]
模拟细胞的纳米颗粒在创伤性脑损伤诊疗中的应用研究
Assaf Zinger,Sirena Soriano,Gherardo Baudo et al.
Assaf Zinger et al.
Traumatic brain injury (TBI) triggers both central and peripheral inflammatory responses. Existing pharmacological drugs are unable to effectively and quickly target the brain inflamed regions, setting up a major roadblock towards effective...
Detailed Balance Broken by Catch Bond Kinetics Enables Mechanical-Adaptation in Active Materials [0.03%]
动失效的 catch bond 动力学使主动材料具备机械适应性
Alan Pasha Tabatabai,Daniel S Seara,Joseph Tibbs et al.
Alan Pasha Tabatabai et al.
Unlike nearly all engineered materials which contain bonds that weaken under load, biological materials contain "catch" bonds which are reinforced under load. Consequently, materials, such as the cell cytoskeleton, can adapt their mechanica...
Inorganic Nanomaterial-Mediated Gene Therapy in Combination with Other Antitumor Treatment Modalities [0.03%]
无机纳米材料介导的基因疗法与其他抗肿瘤治疗手段联用
Guanyou Lin,Richard A Revia,Miqin Zhang
Guanyou Lin
Cancer is a genetic disease originating from the accumulation of gene mutations in a cellular subpopulation. Although many therapeutic approaches have been developed to treat cancer, recent studies have revealed an irrefutable challenge tha...