Kingshuk Dutta,Ritam Das,Jewel Medeiros et al.
Kingshuk Dutta et al.
Nucleic acids are now considered as one of the most potent therapeutic modalities, as their roles go beyond storing genetic information and chemical energy or as signal transducer. Attenuation or expression of desired genes through nucleic ...
FAP-Targeted Photodynamic Therapy Mediated by Ferritin Nanoparticles Elicits an Immune Response against Cancer Cells and Cancer Associated Fibroblasts [0.03%]
基于铁蛋白纳米颗粒介导的靶向光动力治疗激发针对癌细胞和癌症相关成纤维细胞的免疫反应
Shiyi Zhou,Zipeng Zhen,Amy V Paschall et al.
Shiyi Zhou et al.
Cancer-associated fibroblasts (CAFs) are present in many types of tumors and play a pivotal role in tumor progression and immunosuppression. Fibroblast-activation protein (FAP), which is overexpressed on CAFs, has been indicated as a univer...
Hydrolytically degradable Poly (β-amino ester) resins with tunable degradation for 3D printing by projection micro-stereolithography [0.03%]
基于投影微立体光刻技术的可调降解性的聚β-氨基酯材料及用于3D打印的树脂体系
Archish Muralidharan,Robert R McLeod,Stephanie J Bryant
Archish Muralidharan
Applications of 3D printing that range from temporary medical devices to environmentally responsible manufacturing would benefit from printable resins that yield polymers with controllable material properties and degradation behavior. Towar...
Integrin-Targeted, Short Interfering RNA Nanocomplexes for Neuroblastoma Tumor-Specific Delivery Achieve MYCN Silencing with Improved Survival [0.03%]
靶向整合素的短干擾RNA納米復合物實現神經母細胞瘤特異性給藥并沉默MYCN基因取得良好療效
Aristides D Tagalakis,Vignesh Jayarajan,Ruhina Maeshima et al.
Aristides D Tagalakis et al.
The authors aim to develop siRNA therapeutics for cancer that can be administered systemically to target tumors and retard their growth. The efficacy of systemic delivery of siRNA to tumors with nanoparticles based on lipids or polymers is ...
A Light-Curable and Tunable Extracellular Matrix Hydrogel for In Situ Suture-Free Corneal Repair [0.03%]
一种用于原位缝合-free角膜修复的光固化和可调 extracellular 矩阵水凝胶
Ghasem Yazdanpanah,Xiang Shen,Tara Nguyen et al.
Ghasem Yazdanpanah et al.
Corneal injuries are a major cause of blindness worldwide. To restore corneal integrity and clarity, there is a need for regenerative bio-integrating materials for in-situ repair and replacement of corneal tissue. Here, we introduce Light-c...
Void-free 3D Bioprinting for In-situ Endothelialization and Microfluidic Perfusion [0.03%]
无气隙的3D生物打印实现原位内皮化和微流体灌注
Liliang Ouyang,James P K Armstrong,Qu Chen et al.
Liliang Ouyang et al.
Two major challenges of 3D bioprinting are the retention of structural fidelity and efficient endothelialization for tissue vascularization. We address both of these issues by introducing a versatile 3D bioprinting strategy, in which a temp...
Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks [0.03%]
超锐纳米线原位穿透、记录并刺激神经元和心脏网络的细胞内活动
Ren Liu,Jihwan Lee,Youngbin Tchoe et al.
Ren Liu et al.
We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes of intracellular potentials from 3D tissue-like net...
Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System [0.03%]
人体芯片系统的长期电气和机械功能监测
Carlota Oleaga,Andrea Lavado,Anne Riu et al.
Carlota Oleaga et al.
The goal of human-on-a-chip systems is to capture multi-organ complexity and predict the human response to compounds within physiologically relevant platforms. The generation and characterization of such systems is currently a focal point o...
Hydrogels Containing Gradients in Vascular Density Reveal Dose-Dependent Role of Angiocrine Cues on Stem Cell Behavior [0.03%]
含有血管密度梯度的水凝胶揭示了血管生成素信号以剂量依赖性方式调控干细胞行为
Mai T Ngo,Victoria R Barnhouse,Aidan E Gilchrist et al.
Mai T Ngo et al.
Biomaterials that replicate patterns of microenvironmental signals from the stem cell niche offer the potential to refine platforms to regulate stem cell behavior. While significant emphasis has been placed on understanding the effects of b...
Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling [0.03%]
磁热多路复用选择性远程控制细胞信号转导
Junsang Moon,Michael G Christiansen,Siyuan Rao et al.
Junsang Moon et al.
Magnetic nanoparticles have garnered sustained research interest for their promise in biomedical applications including diagnostic imaging, triggered drug release, cancer hyperthermia, and neural stimulation. Many of these applications make...