Light-controlled growth factors release on tetrapodal ZnO-incorporated 3D-printed hydrogels for developing smart wound scaffold [0.03%]
基于四面体ZnO的三维打印水凝胶促进光照控制生长因子释放用于开发智能伤口支架
Leonard Siebert,Eder Luna-Cerón,Luis Enrique García-Rivera et al.
Leonard Siebert et al.
Advanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While wound scaffolds and advanced functionalities have previously been incorporated into one medical device, the wi...
Advanced Materials in Wireless, Implantable Electrical Stimulators That Offer Rapid Rates of Bioresorption for Peripheral Axon Regeneration [0.03%]
用于外周轴突再生的快速生物吸收率的无线植入式电刺激器中的高级材料
Hexia Guo,Dom D&#x;Andrea,Jie Zhao et al.
Hexia Guo et al.
Injured peripheral nerves typically exhibit unsatisfactory and incomplete functional outcomes, and there are no clinically approved therapies for improving regeneration. Post-operative electrical stimulation (ES) increases axon regrowth, bu...
Canran Wang,Ehsan Shirzaei Sani,Wei Gao
Canran Wang
Chronic wounds are a major healthcare issue and can adversely affect the lives of millions of patients around the world. The current wound management strategies have limited clinical efficacy due to labor-intensive lab analysis requirements...
Xiufeng Wang,Yangchengyi Liu,Huanyu Cheng et al.
Xiufeng Wang et al.
The practical applications of skin-interfaced sensors and devices in daily life hinge on the rational design of surface wettability to maintain device integrity and achieve improved sensing performance under complex hydrated conditions. Var...
mRNA Vaccines Against SARS-CoV-2 Variants Delivered by Lipid Nanoparticles Based on Novel Ionizable Lipids [0.03%]
基于新型可电离脂质的脂质纳米颗粒递送的针对SARS-CoV-2变异株的mRNA疫苗
Kepan Chen,Na Fan,Hai Huang et al.
Kepan Chen et al.
SARS-CoV-2 variants are now still challenging all the approved vaccines, including mRNA vaccines. There is an urgent need to develop new generation mRNA vaccines with more powerful efficacy and better safety against SARS-CoV-2 variants. In ...
Lipid-Polymer Hybrid "Particle-in-Particle" Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID-19 Vaccines [0.03%]
用于冻干型DNA和mRNA COVID-19疫苗的脂质聚合物杂合“粒子中之粒子”纳米基因传递平台
Zhongyu Li,Xue-Qing Zhang,William Ho et al.
Zhongyu Li et al.
SARS-CoV-2 has led to a worldwide pandemic, catastrophically impacting public health and the global economy. Herein, a new class of lipid-modified polymer poly (β-amino esters) (L-PBAEs) is developed via enzyme-catalyzed esterification and...
Magnetic Living Hydrogels for Intestinal Localization, Retention, and Diagnosis [0.03%]
用于肠道定位、滞留和诊断的磁性生活水凝胶
Xinyue Liu,Yueying Yang,Maria Eugenia Inda et al.
Xinyue Liu et al.
Natural microbial sensing circuits can be rewired into new gene networks to build living sensors that detect and respond to disease-associated biomolecules. However, synthetic living sensors, once ingested, are cleared from the gastrointest...
Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics [0.03%]
树状纳米凝胶药物的偏离化学计量的硫醇-烯化学
Yuning Zhang,Oliver C J Andrén,Randi Nordström et al.
Yuning Zhang et al.
A novel platform of dendritic nanogels is herein presented, capitalizing on the self-assembly of allyl-functional polyesters based on dendritic-linear-dendritic amphiphiles followed by simple cross-linking with complementary monomeric thiol...
Kingshuk Dutta,Ritam Das,Jewel Medeiros et al.
Kingshuk Dutta et al.
Nucleic acids are now considered as one of the most potent therapeutic modalities, as their roles go beyond storing genetic information and chemical energy or as signal transducer. Attenuation or expression of desired genes through nucleic ...
FAP-Targeted Photodynamic Therapy Mediated by Ferritin Nanoparticles Elicits an Immune Response against Cancer Cells and Cancer Associated Fibroblasts [0.03%]
基于铁蛋白纳米颗粒介导的靶向光动力治疗激发针对癌细胞和癌症相关成纤维细胞的免疫反应
Shiyi Zhou,Zipeng Zhen,Amy V Paschall et al.
Shiyi Zhou et al.
Cancer-associated fibroblasts (CAFs) are present in many types of tumors and play a pivotal role in tumor progression and immunosuppression. Fibroblast-activation protein (FAP), which is overexpressed on CAFs, has been indicated as a univer...