Unmasking the Resolution-Throughput Tradespace of Focused-Ion-Beam Machining [0.03%]
focused-ion-beam加工的分辨率-吞吐率折中分析
Andrew C Madison,John S Villarrubia,Kuo-Tang Liao et al.
Andrew C Madison et al.
Focused-ion-beam machining is a powerful process to fabricate complex nanostructures, often through a sacrificial mask that enables milling beyond the resolution limit of the ion beam. However, current understanding of this super-resolution...
Tailoring electrode surface charge to achieve discrimination and quantification of chemically similar small molecules with electrochemical aptamers [0.03%]
通过调节电极表面电荷使用电化学适配子对化学结构相似的微小分子进行区分和检测
Vladimir Kesler,Kaiyu Fu,Yihang Chen et al.
Vladimir Kesler et al.
Electrochemical biosensors based on structure-switching aptamers offer many advantages because they can operate directly in complex samples and offer the potential to integrate with miniaturized electronics. Unfortunately, these biosensors ...
Two-Photon Polymerized Shape Memory Microfibers: A New Mechanical Characterization Method in Liquid [0.03%]
双光子聚合形状记忆微纤维的新力学表征方法研究
Grayson Minnick,Bahareh Tajvidi Safa,Jordan Rosenbohm et al.
Grayson Minnick et al.
Two-photon polymerization (TPP) has been widely used to create 3D micro- and nanoscale scaffolds for biological and mechanobiological studies, which often require the mechanical characterization of the TPP fabricated structures. To satisfy ...
A Dual-network Nerve Adhesive with Enhanced Adhesion Strength Promotes Transected Peripheral Nerve Repair [0.03%]
一种双网络神经粘合剂促进外周神经断裂修复并具有增强的附着力
Wen Xue,Wen Shi,Mitchell Kuss et al.
Wen Xue et al.
Peripheral nerve transection has a high prevalence and results in functional loss of affected limbs. The current clinical treatment using suture anastomosis significantly limits nerve recovery due to severe inflammation, secondary damage, a...
Single-Cell Transcriptomic Census of Endothelial Changes Induced by Matrix Stiffness and the Association with Atherosclerosis [0.03%]
基质刚度诱导的内皮细胞转录组重编程及其与动脉粥样硬化的关系
Maedeh Zamani,Yu-Hao Cheng,Frank Charbonier et al.
Maedeh Zamani et al.
Vascular endothelial cell (EC) plasticity plays a critical role in the progression of atherosclerosis by giving rise to mesenchymal phenotypes in the plaque lesion. Despite the evidence for arterial stiffening as a major contributor to athe...
Nanofiber Aerogels with Precision Macrochannels and LL-37-Mimic Peptides Synergistically Promote Diabetic Wound Healing [0.03%]
精密宏通道纳米纤维气凝胶与LL-37模拟多肽协同促进糖尿病伤口愈合
Johnson V John,Navatha Shree Sharma,Guosheng Tang et al.
Johnson V John et al.
Fast healing of diabetic wounds remains a major clinical challenge. Herein, this work reports a strategy to combine nanofiber aerogels containing precision macrochannels and the LL-37-mimic peptide W379 for rapid diabetic wound healing. Nan...
Yashavantha L Vishweshwaraiah,Brianna Hnath,Brendan Rackley et al.
Yashavantha L Vishweshwaraiah et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface spike glycoprotein - a major antibody target - is critical for virus entry via engagement of human angiotensin-converting enzyme 2 (ACE2) receptor. Despite successes with ...
Jeff W M Bulte,Chao Wang,Ali Shakeri-Zadeh
Jeff W M Bulte
Superparamagnetic iron oxide (SPIO)-labeling of cells has been applied for magnetic resonance imaging (MRI) cell tracking for over 30 years, having resulted in a dozen or so clinical trials. SPIO nanoparticles are biodegradable and can be b...
Interstitial flow promotes the formation of functional microvascular networks in vitro through upregulation of matrix metalloproteinase-2 [0.03%]
间质流通过上调基质金属蛋白酶-2促进体外功能性微血管网络的形成
Shun Zhang,Zhengpeng Wan,Georgios Pavlou et al.
Shun Zhang et al.
Self-organized microvascular networks (MVNs) have become key to the development of many microphysiological models. However, the self-organizing nature of this process combined with variations between types or batches of endothelial cells (E...
Andrea S Carlini,Wonmin Choi,Naneki C McCallum et al.
Andrea S Carlini et al.
A simple strategy for generating stimuli-responsive peptide-based hydrogels via charge-conversion of a self-assembling peptide (SAP) is described. These materials are formulated as soluble, polyanionic peptides, containing maleic acid, citr...