GSH-activated Porphyrin Sonosensitizer Prodrug for Fluorescence Imaging-guided Cancer Sonodynamic Therapy [0.03%]
用于荧光影像引导癌症声动力治疗的GSH激活式卟啉sonosensitizer前药
Caiting Deng,Meichen Zheng,Shupeng Han et al.
Caiting Deng et al.
Sonodynamic therapy (SDT), which uses ultrasound to trigger a sonosensitizer to generate reactive oxygen species (ROS), is a promising form of cancer therapy with outstanding tissue penetration depth. However, the sonosensitizer may inevita...
Broadband Forward Light Scattering by Architectural Design of Core-Shell Silicon Particles [0.03%]
宽带前向散射的核壳结构硅颗粒建筑学设计
Maria Letizia De Marco,Taizhi Jiang,Jie Fang et al.
Maria Letizia De Marco et al.
A goal in the field of nanoscale optics is the fabrication of nanostructures with strong directional light scattering at visible frequencies. Here, the synthesis of Mie-resonant core-shell particles with overlapping electric and magnetic di...
Amplification of Cerenkov luminescence using semiconducting polymers for cancer theranostics [0.03%]
用于癌症诊疗的切伦科夫发光半导体聚合物放大技术
Zachary T Rosenkrans,Jessica C Hsu,Eduardo Aluicio-Sarduy et al.
Zachary T Rosenkrans et al.
The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL) from radionuclides has recently been proposed as an alternative light source in a s...
Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation [0.03%]
用于长期异种细胞移植的分子界面工程
Sajeesh Kumar Madhurakkat Perikamana,Nailah Seale,Jiaul Hoque et al.
Sajeesh Kumar Madhurakkat Perikamana et al.
Encapsulation of therapeutic cells in a semipermeable device can mitigate the need for systemic immune suppression following cell transplantation by providing local immunoprotection while being permeable to nutrients, oxygen, and different ...
In-drop thermal cycling of microcrystal assembly for senescence control (MASC) with minimal variation in efficacy [0.03%]
微量热循环微晶装量法(MASC)控制衰老且功效差异小
Ryan C Miller,Jonghwi Lee,Young Jun Kim et al.
Ryan C Miller et al.
The secretome from mesenchymal stem cells (MSCs) has recently gained attention for new therapeutics. However, clinical application requires in vitro cell manufacturing to attain enough cells. Unfortunately, this process often drives MSCs in...
An Activity-Based Nanosensor for Minimally-Invasive Measurement of Protease Activity in Traumatic Brain Injury [0.03%]
一种用于创伤性脑损伤中微创测量蛋白酶活性的基于纳米线传感器的方法
Julia A Kudryashev,Marianne I Madias,Rebecca M Kandell et al.
Julia A Kudryashev et al.
Current screening and diagnostic tools for traumatic brain injury (TBI) have limitations in sensitivity and prognostication. Aberrant protease activity is a central process that drives disease progression in TBI and is associated with worse...
Benjamin S Spearman,Vidhi H Desai,Sahba Mobini et al.
Benjamin S Spearman et al.
Research on neural interfaces has historically concentrated on development of systems for the brain; however, there is increasing interest in peripheral nerve interfaces (PNIs) that could provide benefit when peripheral nerve function is co...
Additive Manufacturing of Engineered Living Materials with Bio-augmented Mechanical Properties and Resistance to Degradation [0.03%]
生物增强型工程活材料的力学性能和抗降解性添加剂制造
Gokce Altin-Yavuzarslan,Sierra M Brooks,Shuo-Fu Yuan et al.
Gokce Altin-Yavuzarslan et al.
Engineered living materials (ELMs) combine living cells with polymeric matrices to yield unique materials with programmable functions. While the cellular platform and the polymer network determine the material properties and applications, t...
Oxygen-Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors [0.03%]
基于氧气生成的冻胶体能够在缺氧肿瘤中恢复T细胞介导的细胞毒性功能
Thibault Colombani,Loek J Eggermont,Stephen M Hatfield et al.
Thibault Colombani et al.
Solid tumors are protected from antitumor immune responses due to their hypoxic microenvironments. Weakening hypoxia-driven immunosuppression by hyperoxic breathing of 60% oxygen has shown to be effective in unleashing antitumor immune cell...
Simulation of Cortical and Cancellous Bone to Accelerate Tissue Regeneration [0.03%]
仿皮质骨和松质骨加速组织再生仿真研究
Zhihai Fan,Hongxiang Liu,Zhaozhao Ding et al.
Zhihai Fan et al.
Different tissues have complex anisotropic structures to support biological functions. Mimicking these complex structures in vitro remains a challenge in biomaterials designs in support of tissue regeneration. Here, inspired by different ty...