Nano-Biosensors for mRNA-Based Cell Sorting Using Intracellular Markers at the Early Stage of Cell Reprogramming [0.03%]
基于mRNA的细胞重编程早期阶段使用胞内标志物的纳米生物传感器细胞分选法
Yang Song,Jennifer Soto,Xiao Lin et al.
Yang Song et al.
Cell reprogramming and manufacturing have broad applications in tissue regeneration and disease treatment. However, many derived cell types lack unique cell surface markers for protein-based cell sorting, making it difficult to isolate thes...
Glucose-Facilitated Nanomicelles Cross Peripheral Nerve Barriers to Achieve Drug Delivery to Nerves [0.03%]
葡萄糖介导的纳米胶束跨周围神经屏障实现神经药物输送
Xiaoyan Ma,Yuhao Cai,Sumiran Kumar Gurung et al.
Xiaoyan Ma et al.
Injecting nerve-blocking agents near peripheral nerves is a clinical option for treating post-operative and chronic pain. However, the peripheral nerve barriers (PNBs) pose a physiological barrier that hinders the permeation of nerve-blocki...
Hannah S Theriault,Hannah R C Kimmel,Alison C Nunes et al.
Hannah S Theriault et al.
The initiation of endometriotic lesions is not well understood or characterized because endometriosis is typically diagnosed at an advanced stage. Endometriotic lesions are most often found on pelvic tissues and organs, especially the ovari...
Multifunctional Superparamagnetic Copper Iron Oxide Nanoparticles for Synergistic Cancer Therapy via Magnetic Hyperthermia, Oxidative Stress and Immune Reprogramming [0.03%]
磁性超顺磁性铜铁氧化物纳米粒子的多功能性通过磁热疗，氧化应激和免疫重编程实现协同癌症治疗的能力
Yuxin Cai,Xuejia Kang,Lang Zhou et al.
Yuxin Cai et al.
Aggressive cancers, characterized by high metastatic potential and resistance to conventional therapies, present a significant challenge in oncology. Current treatments often fail to effectively target metastasis, recurrence, and the immuno...
Twinkling Peptide Nanoemulsions Enable Precision Ultrasound Detection of Atherosclerotic Plaques [0.03%]
闪烁肽纳米乳剂可实现动脉粥样硬化斑块的精准超声检测
Inhye Kim,Jacob C Elliott,Atip Lawanprasert et al.
Inhye Kim et al.
Non-invasive imaging modalities that identify rupture-prone atherosclerotic plaques hold promise to improve patient risk stratification and advance early intervention strategies. Here, phase-changing peptide nanoemulsions are developed as t...
Continuous Production of Highly Functional Vascularized Hepatobiliary Organoids from Human Pluripotent Stem Cells using a Scalable Microfluidic Platform [0.03%]
基于人类多能干细胞的血管化肝胆器官芯片的连续生产
Saeed Abbasalizadeh,Sahab Babaee,Reza Kowsari-Esfahan et al.
Saeed Abbasalizadeh et al.
"Organoid medicine" has rapidly progressed over the past decade as a new class of therapeutics with high functionality and complexity for addressing unmet medical needs such as effective treatment of patients suffering from chronic liver di...
Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neurostimulation Technology Development [0.03%]
超小型碳电极光电动势刺激神经组织的潜力——神经刺激技术发展的新方向
Keying Chen,Bingchen Wu,Daniela Krahe et al.
Keying Chen et al.
Neuromodulation technologies have gained considerable attention for their clinical potential in treating neurological disorders and advancing cognition research. However, traditional methods like electrical stimulation and optogenetics face...
A Pumpless, High-Throughput Microphysiological System to Mimic Enteric Innervation of Duodenal Epithelium and the Impact on Barrier Function [0.03%]
一种无泵浦、高通量的微生理系统模仿肠神经系统对十二指肠上皮屏障功能的影响
Kyla N Kaiser,Jessica R Snyder,Ryan A Koppes et al.
Kyla N Kaiser et al.
Enteric neurons are critical in maintaining organ homeostasis within the small intestine, and their dysregulation are implicated in gastrointestinal disorders and neurodegenerative diseases. Most in vitro models lack enteric innervation, li...
Precision-Engineered Cobalt-doped Iron Oxide Nanoparticles: From Octahedron Seeds to Cubical Bipyramids for Enhanced Magnetic Hyperthermia [0.03%]
精准工程 cobalt 掺杂铁氧化纳米颗粒：从八面体种子到立方双锥以增强磁性超声热疗
Prem Singh,Karthickraja Duraisamy,Constanze Raitmayr et al.
Prem Singh et al.
Despite notable advancements, the significantly improved yet suboptimal heating efficiency of current magnetic nanoparticles hinders the effectiveness of systemically delivered magnetic hyperthermia in reducing tumor size or halting growth....
Microbubble-Controlled Delivery of Biofilm-Targeting Nanoparticles to Treat MRSA Infection [0.03%]
微泡控制靶向生物膜纳米颗粒用于治疗MRSA感染
Ju Yeon Chung,Yujin An,Joo Hun Lee et al.
Ju Yeon Chung et al.
Drug-resistant microorganisms cause serious problems in human healthcare, leading to the persistence in infections and poor treatment outcome from conventional therapy. In this study, we introduce a gene targeting strategy using microbubble...