Noninvasive Assessment of Protease Activity in Osteosarcoma via Click Chemistry-Mediated Enrichment of Extracellular Vesicles [0.03%]
You-Ren Ji,Junseok Lee,Hyoyong Kim et al.
You-Ren Ji et al.
Osteosarcoma (OS), the most common bone cancer in children, is characterized by aggressive tumors and subclinical metastasis. Metastasis significantly impacts OS patient survival rate, highlighting the need for frequent assessment of diseas...
Xiujun Fan,Songyue Chen,Farid Manshaii et al.
Xiujun Fan et al.
The development of soft mechanocaloric materials is becoming increasingly important due to the growing demand for energy-efficient and environmentally friendly thermoregulation solutions. Here the mechanocaloric effects in soft materials, w...
MPI-Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers [0.03%]
基于MPI引导的前列腺癌光热治疗的磁诊疗纳米花及其干细胞递送研究
Behnaz Ghaemi,Ana Rosu,Shreyas Kuddannaya et al.
Behnaz Ghaemi et al.
The efficacy of photothermal therapy (PTT) of cancer critically depends on widespread nanoparticle (NP) distribution and retention within the tumor. However, intratumoral (i.t.) injection of naked NPs may result in poor dispersion and backf...
Physiologically Adaptive Soft Millirobot for Atraumatic Endovascular Therapy [0.03%]
自适应柔软毫米级血管机器人用于微创介入治疗
Tuan-Anh Le,Husnu H Alabay,Prabh G Singh et al.
Tuan-Anh Le et al.
Atraumatic and localized drug delivery to the vascular endothelium remains a critical unmet need in interventional medicine, with major implications for arterial and venous disease management. Here, we present EndoBot, a soft, untethered mi...
Anionic Citrate-Based 3D-Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration [0.03%]
用于调节和持续递送组织工程生物活性分子的基于枸橼酸的阴离子三维打印支架增强再生医学研究
Se-Hwan Lee,Ruqiang Lu,Andrew House et al.
Se-Hwan Lee et al.
Sustained and controlled release systems for orthobiologics enhance therapeutic efficacy by enabling precise biomolecule delivery. While bone morphogenetic protein-2 (BMP-2) in combination with bone grafts has shown promise in orthopedic ap...
Oxidation-degradable resins for 3D-printing of cell-responsive biomaterials [0.03%]
用于细胞响应生物材料的3D打印的可氧化降解树脂
Reinaldo L Dos Santos,Wesley Wynn,Lindsey Marquez et al.
Reinaldo L Dos Santos et al.
Additive manufacturing, or 3D printing, has emerged as a powerful tool for rapidly generating tissue engineering constructs with complex architectures. While hydrolysis-sensitive polyesters are most commonly used to 3D print these scaffolds...
Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral-Like Immunomodulatory Responses and Potent Adjuvant Activity [0.03%]
用于调节抗病毒免疫反应和有效佐剂活性的核酸纳米粒子化学空间的拓展
Martin Panigaj,Hannah S Newton,Jian Wang et al.
Martin Panigaj et al.
The rise of personalized medicine demands affordable biomaterials with tunable physicochemical properties, biological activities, and immune responses. We introduce a nucleic acid nanoparticle (NANP)-based platform designed to engage with t...
Engineering Drug-Eluting Ocular Bioadhesive "OcuTAPE" via Tannic Acid-Mediated Nanoparticle Bridging [0.03%]
基于单宁酸介导的纳米粒子交联的眼用控释“OcuTAPE”智能载体工程学研究
Yuting Zheng,Monu Monu,Steven Vo et al.
Yuting Zheng et al.
Dynamic integration of nanoparticles (NPs) into hydrogels remains a key challenge in engineering drug-eluting bioadhesives. A generalizable strategy leveraging the multifunctional binding capacity of tannic acid (TA) to bridge drug-loaded N...
Engineering the microstructure and spatial bioactivity of MAP scaffolds instructs vasculogenesis in vitro and modifies vessel formation in vivo [0.03%]
工程化MAP支架的微观结构和空间生物活性可指导体外血管发生及改变体内血管形成
Alexa R Anderson,Eleanor L P Caston,Lindsay Riley et al.
Alexa R Anderson et al.
In tissues where the vasculature is either lacking or abnormal, biomaterials can be designed to promote vessel formation and enhance tissue repair. In this work, we independently tune the microstructure and bioactivity of microporous anneal...
High-Resolution Characterization of Protein-Conjugated, mRNA-Loaded Lipid Nanoparticles by Analytical Ultracentrifugation [0.03%]
分析性超速离心技术表征与蛋白质结合的、装载有信使RNA的脂质纳米颗粒
Sophia Bird,Connor Smith,Nahal Habibi et al.
Sophia Bird et al.
The study describes a novel use for the Custom Grid (CG) algorithm in UltraScan targeting lipid nanoparticles (LNPs) with cargos ranging from empty LNPs, LNPs loaded with messenger RNA (mRNA), and LNPs conjugated with proteins, or both. The...