Assessing Discrepancies in miRNA Profiles of Mouse Blood-Derived Extracellular Vesicles: A Systematic Review of Sequencing Data [0.03%]
基于小鼠血液来源外泌体的系统评价：对miRNA谱系差异的序列表达数据分析综述研究
Md Sorwer Alam Parvez,Erika Hayakawa,Yoritsugu Iida et al.
Md Sorwer Alam Parvez et al.
We systematically reviewed published studies to assess reproducibility in miRNA expression profiles from extracellular vesicles (EVs) isolated from mouse serum. Our search specifically targeted mouse studies employing precipitation methods ...
Proteome-Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling [0.03%]
泛素化蛋白质组学揭示了免疫早期信号传导的新见解
Hyojung Kim,Jiraphorn Issara-Amphorn,Sung Hwan Yoon et al.
Hyojung Kim et al.
Protein S-palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains...
Xiaorui Cheng,Haixia Wu,Pengji Chen et al.
Xiaorui Cheng et al.
CD8+ T-cell epitopes are special peptide fragments produced by the catabolism of antigenic proteins. After being presented on the surface of antigen-presenting cells in association with Major Histocompatibility Complex-I (MHC-I) molecules, ...
Performance Characteristics of Zeno Trap Scanning DIA for Sensitive and Quantitative Proteomics at High Throughput [0.03%]
高通量敏感定量蛋白质组学的Zeno阱扫描DIA性能特征分析
Ludwig R Sinn,Ziyue Wang,Claudia P Alvarez et al.
Ludwig R Sinn et al.
Proteomic experiments, particularly those addressing dynamic proteome properties, time series, or genetic diversity, require the analysis of large sample numbers. Despite significant advancements in proteomic technologies in recent years, f...
Time-Enduring Proteomic Fidelity in Over 30-Year-Old FFPE Tissues: Distinct Proteomic Signatures of Hepatocellular Carcinoma and Adjacent Non-Tumor Liver Tissue [0.03%]
超过30年史的石蜡包埋组织蛋白质组的长期稳定性及高质量深度 Coverage 分析：肝癌与临近非肿瘤肝脏组织的蛋白质组特征分析
Yuki Adachi,Masatsugu Ishii,Rei Noguchi et al.
Yuki Adachi et al.
Formalin-fixed paraffin-embedded (FFPE) tissues are crucial clinical archives linked with long-term follow-up data, yet the suitability of deep proteomic analysis on samples stored over 30 years remains largely unexplored. This study aimed ...
In-Cell Proteomics Enables High-Resolution Temporal Profiling of Cell Cycle Progression and DNA Damage Response in Saccharomyces cerevisiae [0.03%]
细胞内蛋白质组学实现了对酿酒酵母细胞周期进程和DNA损伤反应的高分辨率时间过程分析
Henry Nwaora,Yanbao Yu,Zhihao Zhuang
Henry Nwaora
Yeast is a widely used model organism in biological and proteomics research. Conventional bottom-up proteomic analysis of yeast cells requires disruption of the rigid cell wall to extract proteins, which is often associated with lengthy pro...
Advancing Understanding of the Protein Composition of Human Seminal Extracellular Vesicles [0.03%]
推进对人类精液细胞外囊泡蛋白组成理解的研究
Cottrell T Tamessar,Shanmathi Parameswaran,Elizabeth Torres-Arce et al.
Cottrell T Tamessar et al.
Seminal extracellular vesicles (SEVs) carry a diverse array of bioactive molecules, including proteins, lipids, and nucleic acids, which influence sperm function and have potential to modulate the female reproductive tract immune response a...
A Proteomics Resource Investigating Fibrosis: Proof-of-Concept for Identifying Novel Drug Candidates [0.03%]
一项关于纤维化的蛋白质组学研究：寻找新型药物候选物的概念验证
Hanne Devos,Manousos Makridakis,Rafael Stroggilos et al.
Hanne Devos et al.
Fibrosis is characterised by inappropriate wound healing and the buildup of excessive fibrous connective tissue, in particular within the extracellular matrix (ECM). This can occur in multiple organs, ultimately leading to organ failure. De...
Aleksandra Nita-Lazar
Aleksandra Nita-Lazar
Probing Early α-Synuclein Oligomers: Insights Into Aggregation Pathways of NACore and preNAC Segments Probed by Trapped Ion-Mobility Mass Spectrometry and Fluorescence Spectroscopy [0.03%]
通过捕集离子淌度质谱和荧光光谱研究早期α-突触核蛋白寡聚体：NACore和preNAC片段聚集途径的见解
Agathe Depraz Depland,Stephanie Mikromanolis,Iuliia Stroganova et al.
Agathe Depraz Depland et al.
Misfolding and aggregation of α-Synuclein (α-Syn) play a central role in Parkinson's disease (PD), with oligomeric intermediates implicated as key toxic species. Here, we investigate the aggregation of two α-Syn segments, the NACore (68G...