Nimita Kant,Anand Kumar Bharti,Shailender Kumar Verma
Nimita Kant
Metal ions are crucial for viral processes like replication, structural integrity and immune modulation, despite that the metalloproteome of Monkeypox virus (MPXV) remains largely unexplored. Monkeypox virus is a re-emerging zoonotic Orthop...
Optimized Sample Handling Minimizes Peptide Adsorption to Plastics to Enable High Sensitivity Evosep Based Chemical Proteomics [0.03%]
优化样品处理可最小化塑料吸附以实现高灵敏度的Evosep化学蛋白质组学分析
Amrita Date,Anne Schuhmacher,Jianan Lu et al.
Amrita Date et al.
Chemical proteomics approaches often yield low peptide recovery because they aim to enrich low-abundance proteins. Poor sample handling further reduces recovery through peptide adsorption to plastic surfaces and losses due to vacuum evapora...
Toward Predicting Pandemic Potential: A Comparative Analysis of Virus-Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System [0.03%]
预测流行潜力的探索：多种甲型流感病毒与人类固有免疫系统相互作用的比较分析
Antoine Gerodez,Melanie Dos Santos,Mikaël Attia et al.
Antoine Gerodez et al.
Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species-speci...
Functional Divergence of Mucus in Pacific Oyster (Crassostrea gigas): Insights From Integrated Proteomic and Rheological Study [0.03%]
太平洋牡蛎（Crassostrea gigas）黏液功能分化：整合蛋白组学和流变学研究的见解
Shiyu Cui,Xiutong Wang,Linlin Zhang et al.
Shiyu Cui et al.
Crassostrea gigas survives in the intertidal zone by relying on tissue-specific mucus secreted by different organs. However, the macroscopic differentiation of mucus physical properties and their molecular mechanisms remain poorly understoo...
Proteome-Wide Dissection of Cachexia-Inducing Evolution in a Paired Human Neuroendocrine Carcinoma Cell Line Model [0.03%]
人神经内分泌癌细胞系模型介导恶病质的蛋白质组演化解析
Julia Osaki,Yomogi Shiota,Kazuyoshi Yanagihara et al.
Julia Osaki et al.
Cancer cachexia is a devastating systemic syndrome, yet tumor-intrinsic programs that enable cachexia induction remain poorly defined. Here we dissect cachexia-inducing tumor evolution using a uniquely paired model derived from a rare human...
Effect of Nutritional Intervention on the Milk Fat Globule Membrane Proteome of Colostrum From Lactating Yaks [0.03%]
营养干预对牦牛初乳乳脂肪球膜蛋白组学的影响
Zhenyu Zhu,Xinsheng Zhao,Zhanming Yang et al.
Zhenyu Zhu et al.
Purpose: This study aimed to investigate the effects of nutritional intervention on the milk fat globule membrane (MFGM) proteome of colostrum from lactating yaks to provide a theoretical basis for understanding potential...
Stage-Resolved Proteomic and Structural Insights Into Apocarotenoid Biosynthesis During Saffron (Crocus sativus) Flower Development [0.03%]
藏红花(Crocus sativus)开花过程中类胡萝卜素降解衍生生物合成的阶段特异性蛋白质组和结构见解
Namita Muduli,Pabitra Mohan Behera,Suchitrarani Sahoo et al.
Namita Muduli et al.
Saffron (Crocus sativus L.) is one of the world's most valuable spices, renowned for its distinctive aroma, flavor, and pharmacological properties derived from apocarotenoids such as crocin, picrocrocin, and safranal, which accumulate in th...
Unspecific Molecular Adsorption (UMA) Sample Preparation Method for Bottom-up and Whole Protein Analysis: The Foundation [0.03%]
非特异性分子吸附（UMA）样品制备方法用于自下而上及全蛋白分析：基础篇
Alexandre Zougman
Alexandre Zougman
The protein sample preparation methods for shotgun proteomics are nowadays well-established unlike the ones for whole protein analysis. The goal of my work has been to create a simple methodology which provides a single uncomplicated sample...
High-throughput Phosphoproteomics Reveals the Role of Phosphorylation in Pluripotency and Phase Separation [0.03%]
高通量磷酸蛋白质组学揭示了多能性及相分离中磷酸化的作用
Yanna Tang,Haiming Huang,Ting Wu et al.
Yanna Tang et al.
Phosphorylation is a key post-translational modification involved in many cellular processes. Embryonic stem cells (ESCs), characterized by their self-renewal capacity and pluripotent differentiation potential, are widely used in studies of...
Joshua N Sargeant,Paul D Gershon
Joshua N Sargeant
The poxvirus family has a unique but uncharacterized mechanism of cell entry involving an 11-chain entry-fusion complex (EFC) anchored to the virus envelope. A computationally confident AlphaFold model for holoEFC contained all 11 chains in...