Protein Paucimannosylation Is an Enriched N-Glycosylation Signature of Human Cancers [0.03%]
贫寡糖蛋白修饰是人类肿瘤中富集的N-连接糖基化标志
Sayantani Chatterjee,Ling Y Lee,Rebeca Kawahara et al.
Sayantani Chatterjee et al.
While aberrant protein glycosylation is a recognized characteristic of human cancers, advances in glycoanalytics continue to discover new associations between glycoproteins and tumorigenesis. This glycomics-centric study investigates a poss...
Special Issue on Single-Cell Multiomics for Immuno-Oncology and Cancer Systems Biology [0.03%]
免疫肿瘤学和癌症系统生物学的单细胞多组学专题讲座
Wei Wei,Rong Fan
Wei Wei
Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity [0.03%]
“老化蛋白”的积累和基于质谱的蛋白质周转测量在衰老和长寿研究中的关键作用
Nathan Basisty,Anja Holtz,Birgit Schilling
Nathan Basisty
Aging and age-related diseases are accompanied by proteome remodeling and progressive declines in cellular machinery required to maintain protein homeostasis (proteostasis), such as autophagy, ubiquitin-mediated degradation, and protein syn...
Proteomics Reveals Cell-Surface Urokinase Plasminogen Activator Receptor Expression Impacts Most Hallmarks of Cancer [0.03%]
蛋白质组学揭示尿激酶型 plamin 活性酶受体表达影响绝大多数肿瘤标志特性
Seong Beom Ahn,Abidali Mohamedali,Dana Pascovici et al.
Seong Beom Ahn et al.
While metastasis is the primary cause of colorectal cancer (CRC) mortality, the molecular mechanisms underpinning it remains elusive. Metastasis is propagated through driver oncogene/suppressor gene mutations, accompanied by passenger mutat...
Lipidomic Analysis Reveals Altered Fatty Acid Metabolism in the Liver of the Symptomatic Niemann-Pick, Type C1 Mouse Model [0.03%]
脂质组分析揭示Niemann-Pick型C1鼠标模型肝脂肪酸代谢改变
Melissa R Pergande,Fidel Serna-Perez,Sheher Banu Mohsin et al.
Melissa R Pergande et al.
Niemann-Pick disease, type C1 (NPC1) is a fatal, autosomal recessive, neurodegenerative disorder caused by mutations in the NPC1 gene. As a result of the genetic defect, there is accumulation of unesterified cholesterol and sphingolipids in...
Lipidomic Analysis Reveals Altered Fatty Acid Metabolism in the Liver of the Symptomatic Niemann-Pick, Type C1 Mouse Model [0.03%]
脂质组分析揭示Niemann-Pick型C1鼠标模型肝脂肪酸代谢异常
Melissa R Pergande,Fidel Serna-Perez,Sheher Banu Mohsin et al.
Melissa R Pergande et al.
Niemann-Pick disease, type C1 (NPC1) is a fatal, autosomal recessive, neurodegenerative disorder caused by mutations in the NPC1 gene. As a result of the genetic defect, there is accumulation of unesterified cholesterol and sphingolipids in...
Nazha Sidahmed-Adrar,Jean-François Ottavi,Nassima Benzoubir et al.
Nazha Sidahmed-Adrar et al.
Hepatocellular carcinoma (HCC) is the second cause of cancer-related deaths worldwide. A clearer understanding of the molecular mechanisms underlying tumor growth and invasiveness remains crucial for developing new therapies. Here, the expr...
Nazha Sidahmed-Adrar,Jean-François Ottavi,Nassima Benzoubir et al.
Nazha Sidahmed-Adrar et al.
Hepatocellular carcinoma (HCC) is the second cause of cancer-related deaths worldwide. A clearer understanding of the molecular mechanisms underlying tumor growth and invasiveness remains crucial for developing new therapies. Here, the expr...
Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging [0.03%]
衰老之路——如何运用酵母的系统生物学手段揭示人类个性化的衰老机制？
Matthew M Crane,Kenneth L Chen,Ben W Blue et al.
Matthew M Crane et al.
All organisms age, but the extent to which all organisms age the same way remains a fundamental unanswered question in biology. Across species, it is now clear that at least some aspects of aging are highly conserved and are perhaps univers...
Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging [0.03%]
衰老的轨迹——如何运用酵母中的系统生物学阐释个性化的衰老机制？
Matthew M Crane,Kenneth L Chen,Ben W Blue et al.
Matthew M Crane et al.
All organisms age, but the extent to which all organisms age the same way remains a fundamental unanswered question in biology. Across species, it is now clear that at least some aspects of aging are highly conserved and are perhaps univers...