Advancing Sustainable Dispersive Liquid-Liquid Microextraction: Methodological Formats and Eco-Friendly Solvents for Heavy Metal Analysis [0.03%]
可持续 dispersive liquid-liquid microextraction 在重金属分析中的方法学形式及环保溶剂研究进展
Jameel Ahmed Baig,Muhammad Balal Arain,Tasneem Gul Kazi et al.
Jameel Ahmed Baig et al.
Heavy metals are among the most hazardous chemical pollutants, present in trace amounts in various samples. Prior to the quantitative measurement of heavy metals in a sample, an effective sample preparation technique is usually adopted. Amo...
Novel Strongly Basic Molecularly Imprinted Solid-Phase Extraction Sorbent for Simultaneous Determination of Catecholamines and Their Metabolites in Urine [0.03%]
一种用于同时测定尿液中儿茶酚胺及其代谢物的新型强碱性分子印迹固相萃取吸附剂
Artūrs Šilaks,Antons Podjava,Laura Bernāte et al.
Artūrs Šilaks et al.
Catecholamines are important hormones and neuromediators in the human body. Simultaneous determination of both catecholamines and catecholamine metabolites in bodily fluids can help accurately diagnose dangerous health conditions like adren...
Metabolic Profiling of Panax notoginseng Saponins in Rat Feces Under Colitis by UHPLC-QTOF-MS/MS [0.03%]
基于UHPLC-QTOF-MS/MS的肠道炎症条件下三七皂苷大鼠粪代谢轮廓研究
Jie Zhou,Li Shao,Jing Liu et al.
Jie Zhou et al.
The biotransformation of Panax notoginseng saponins (PNS) is pertinent to the effect of colitis mediated by gut microbiota, which has variant microbes and diversities in inflammatory bowel diseases (IBDs). However, the metabolic profiles of...
A Robust and Universal LC-MS/MS Method for Determination of N-Nitrosodimethylamine in Pharmaceuticals Using a C30 Column [0.03%]
一种使用C30色谱柱测定药物中N-亚硝基二甲胺的LC-MS/MS方法
Byungchan An,Unyong Kim,Sumin Seo et al.
Byungchan An et al.
Since the 2018 valsartan recall, the genotoxic impurity N-nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed...
Impurity Profiling of an Antibody-Antibiotic Conjugate (AAC) Drug-Linker Using Multiple 2D-LC Modes [0.03%]
利用多种二维液相色谱模式对抗体-抗生素偶联药物连接物进行杂质图谱分析
Jenny Wang,Kelly Zhang,Alexandre Goyon
Jenny Wang
Antibody-antibiotic conjugates (AACs) represent a class of highly potent biopharmaceuticals in which monoclonal antibodies (mAbs) are conjugated to antibiotic payloads via chemical linkers. Characterizing the peak purity and impurity profil...
Affinity Capillary Electrophoresis for the Study of Biomolecular Interactions: Recent Advances and Future Perspectives [0.03%]
亲和毛细管电泳在生物分子相互作用研究中的最新进展及未来前景
Yahui Jin,Dapeng Zhang,Hailin Wang
Yahui Jin
Biomolecular interactions, such as protein-protein, protein-DNA, and protein-RNA interactions, are foundational to numerous vital biological processes and underpin the theoretical basis for disease diagnostics, therapeutic strategies, and d...
Thermodynamic and Kinetic Parameters of Four Drugs Toward Beta-2 Adrenergic Receptor Were Measured Robustly and Accurately Through a Chromatographic Column With CotB1 Peptide-Mediated Immobilization [0.03%]
四种药物针对β2肾上腺素受体的热力学和动力学参数被通过一种新型层析介质（专利号：ZL 2018 1 0975364.7）的色谱柱准确测量出来
Pei Wang,Ning Cui,Ru Xu et al.
Pei Wang et al.
Thermodynamics and kinetics of drug-protein interactions are key indices for evaluating pharmacological activity during the early stages of drug discovery. In this work, the recombinant beta-2 adrenergic receptor (β2AR) with the fusion of ...
Host-Dependent Metabolomic Variations in Viscum coloratum Revealed by UHPLC-Q-TOF-MS/MS and Integrated Annotation Strategies [0.03%]
基于UHPLC-Q-TOF-MS/MS和整合注释策略的槲寄生养胎素宿主内代谢组差异分析
Jiajie Wang,Jiong Chen,Xiaoyu Ju et al.
Jiajie Wang et al.
Viscum coloratum (Kom.) Nakai, a widely distributed hemiparasitic medicinal plant in Asia, exhibits host-influenced metabolic traits that remain inadequately characterized. To further investigate this issue, an untargeted metabolomics appro...
Microwave-Assisted Meta-Chloroperoxybenzoic Acid Epoxidation for Qualitative and Quantitative Analysis of Unsaturated Lipid Double-Bond Positional Isomers by Liquid Chromatography-Tandem Mass Spectrometry [0.03%]
微波辅助间氯过苯甲酸环氧化法结合液相色谱-串联质谱法定量和定性分析不饱和脂类双键位置异构体
Danyang Liu,Hongjin Chen,Yong Huang et al.
Danyang Liu et al.
Unsaturated lipid double-bond (C═C) positional isomers are closely related to lipid structure and biological function, but their reliable qualitative and quantitative analysis remains challenging by conventional liquid chromatography-mass ...
Hydrogen-bonded Organic Frameworks Decorated Polymeric High Internal Phase Emulsions as Adsorbents for Solid-Phase Extraction of Estrogens [0.03%]
氢键有机框架修饰聚合高内相Pickering乳液固相萃取雌激素吸附剂
Jiazhen Wei,Shi Yu,Yuji Ruan et al.
Jiazhen Wei et al.
Due to lipid-rich and severe matrix interference, the accurate determination of trace estrogens in cosmetics is highly challenging. Although solid-phase extraction (SPE) is widely used to mitigate the matrix interference, conventional adsor...