Synthesis of 2,3,4-Trisubstituted Thiochromanes using an Organocatalytic Enantioselective Tandem Michael-Henry Reaction [0.03%]
以有机小分子催化烯胺Michael加成-亨rys封端反应串联为关键步骤合成3位取代的硫色满化合物
Rajasekhar Dodda,Joshua J Goldman,Tanmay Mandal et al.
Rajasekhar Dodda et al.
Enantioenriched 2,3,4-trisubstituted thiochromanes have been synthesized by using a cupreine-catalyzed tandem Michael addition-Henry reaction between 2-mercaptobenzaldehydes and β-nitrostyrenes. Good diastereoselectivities and enantioselec...
Studies on the Bisoxazoline and (-)-Sparteine Mediated Enantioselective Addition of Organolithium Reagents to Imines [0.03%]
手性双氧唑啉和(-)-斯巴汀配体在亚胺的对映选择性有机锂试剂加成反应中的应用研究
Scott E Denmark,Noriyuki Nakajima,Cory M Stiff et al.
Scott E Denmark et al.
The enantioselective addition of organolithium reagents to N-anisyl aldimines promoted by chiral bisoxazolines and (-)-sparteine as external ligands is described. This reaction proceeds readily with a wide range of aldimine substrates (alip...
Real-Time Imaging of Protease Action on Substrates Covalently Immobilised to Polymer Supports [0.03%]
共价固定于聚合物载体的底物的蛋白酶作用实时成像技术
Joseph Deere,Gail McConnell,Antonia Lalaouni et al.
Joseph Deere et al.
We report for the first time single bead spatially resolved activity measurements of solid-phase biocatalytic systems followed in real-time. Trypsin cleavage of Bz-Arg-OH and subtilisin cleavage of Z-Gly-Gly-Leu-OH each liberate a free amin...