Expanding the Scope of Biocatalysis: Oxidative Biotransformations on Solid-Supported Substrates [0.03%]
扩大生物催化的范围：固载底物的氧化生物转化反应
Sarah J Brooks,Lydie Coulombel,Disha Ahuja et al.
Sarah J Brooks et al.
Oxidative biocatalytic reactions were performed on solid-supported substrates, thus expanding the repertoire of biotransformations that can be carried out on the solid phase. Various phenylacetic and benzoic acid analogs were attached to co...
Palladium-Catalyzed Aryl Amination Reactions of 6-Bromo- and 6-Chloropurine Nucleosides [0.03%]
钯催化6-溴和6-氯嘌呤核苷的芳胺化反应
Paul F Thomson,Pallavi Lagisetty,Jan Balzarini et al.
Paul F Thomson et al.
Palladium-catalyzed C-N bond forming reactions of 6-bromo- as well as 6-chloropurine ribonucleosides and the 2'-deoxy analogues with aryl amines are described. Efficient conversions were observed with Pd(OAc)(2)/Xantphos/Cs(2)CO(3), in PhMe...
Bruce H Lipshutz,David W Chung,Brian Rich
Bruce H Lipshutz
Unsymmetrical di- and triarylamines can be formed under green chemistry conditions, taking advantage of micellar catalysis leading to palladium-catalyzed aminations at ambient temperatures in water as the only medium.
Gold(I)-Catalyzed Intramolecular Hydroamination of N-Allylic,N'-Aryl Ureas to form Imidazolidin-2-ones [0.03%]
金(I)催化N-烯丙基-N'-芳基尿素分子内的氢胺化反应形成咪唑烷-2-酮类化合物
Hao Li,Feijie Song,Ross A Widenhoefer
Hao Li
Treatment of N-allylic,N'-aryl ureas with a catalytic 1:1 mixture of di-tert-butyl-o-biphenylphoshphine gold(I) chloride and silver hexafluorophosphate (1 mol %) in chloroform at room temperature led to 5-exo hydroamination to form the corr...
Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition [0.03%]
基于Hsp90抑制的新型茋类衍生物抗肿瘤药物的高效合成
Xiaoguang Lei,Samuel J Danishefsky
Xiaoguang Lei
The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using "click chemistry." The preliminary biological ev...
Aerobic Oxidative Coupling of o-Xylene: Discovery of 2-Fluoropyridine as a Ligand to Support Selective Pd-Catalyzed C-H Functionalization [0.03%]
邻甲基苯乙烯的有氧偶联：发现氟代吡啶是支持钯催化C-H功能化的配体
Yusuke Izawa,Shannon S Stahl
Yusuke Izawa
An improved method for direct oxidative coupling of o-xylene could provide streamlined access to an important monomer used in polyimide resins. The use of 2-fluoropyridine as a ligand has been found to enable unprecedented levels of chemo- ...
Pd/P(t-Bu)(3)-Catalyzed Suzuki Cross-Couplings in the Presence of Water [0.03%]
水存在下的Suzuki交叉偶联反应催化剂Pd/P(t-Bu)_3
Sha Lou,Gregory C Fu
Sha Lou
Pd(2)(dba)(3)/[HP(t-Bu)(3)]BF(4)/KF•2H(2)O serves as a mild, robust, and user-friendly method for the efficient Suzuki cross-coupling of a diverse array of aryl and heteroaryl halides with aryl- and heteroarylboronic acids.
Iridium Catalyzed Hydro-hydroxyalkylation of Butadiene: Carbonyl Crotylation [0.03%]
用于丁二烯的铱催化氢-羟基烷基化反应：羰基crotylation反应
Jason R Zbieg,Takeo Fukuzumi,Michael J Krische
Jason R Zbieg
Exposure of alcohols 1a-1i to butadiene in the presence of a cyclometallated iridium catalyzed derived from allyl acetate, 4-methoxy-3-nitrobenzoic acid and BIPHEP (2,2'-bis(diphenylphosphino)biphenyl) results in hydrogen transfer to genera...
Salicylaldimine Ruthenium Alkylidene Complexes: Metathesis Catalysts Tuned for Protic Solvents [0.03%]
水性溶剂中Metathesis催化剂的调控：邻苯二甲酰亚胺钌炔基配合物的例子
Joseph B Binder,Ilia A Guzei,Ronald T Raines
Joseph B Binder
Tuning the electronic and steric environment of olefin metathesis catalysts with specialized ligands can adapt them to broader applications, including metathesis in aqueous solvents. Bidentate salicylaldimine ligands are known to stabilize ...
Direct Copper-Free Domino Conjugate Addition-Cycloallylation using Organozinc Reagents [0.03%]
无需铜的有机锌试剂连续加成-环丙基化反应
Venukrishnan Komanduri,Fernando Pedraza,Michael J Krische
Venukrishnan Komanduri
The Direct Approach: Enones possessing appendant allylic carbonates react directly with diorganozinc reagents in the presence of zinc diiodide [ZnI(2)] to provide 5- and 6-membered ring products of tandem or domino conjugate addition-cycloa...