Zea Strassberger,Maurice Mooijman,Eelco Ruijter et al.
Zea Strassberger et al.
We combine multicomponent reactions, catalytic performance studies and predictive modelling to find transfer hydrogenation catalysts. An initial set of 18 ruthenium-carbene complexes were synthesized and screened in the transfer hydrogenati...
Synthesis of α-Arylphosphonates Using Copper-Catalyzed α-Arylation and Deacylative α-Arylation of β-Ketophosphonates [0.03%]
铜催化β-酮亚磷酸酯的α-芳基化及脱酰基α-芳基化合成α-芳基亚磷酸酯
Laxmidhar Rout,Sridhar Regati,Cong-Gui Zhao
Laxmidhar Rout
Efficient methods for the direct arylation and deacylative arylation of β-ketophosphonates with iodoarenes in presence of a copper(I) or a copper(II) salt as the catalysts were developed. The corresponding α-arylphosphonates were obtained...
Iridium-Catalyzed Allylic Amination Route to α-Aminoboronates: Illustration of the Decisive Role of Boron Substituents [0.03%]
铱催化α-氨基硼酸酯的烯丙基胺化反应：硼取代基决定性的角色分析
Sabrina Touchet,François Carreaux,Gary A Molander et al.
Sabrina Touchet et al.
The development of a new route to α-aminoboronates using an iridium-catalyzed allylic amination on boronated substrates is described. Unlike the boronate group, the trifluoroborato substituent was found to govern the regioselectivity exclu...
The Efficient and Enantiospecific Total Synthesis of Cyclopenta[b]phenanthrenes Structurally-related to Neurosteroids [0.03%]
与神经甾体结构相关的环戊并[б]菲烷的高效对映选择性全合成
Mingxing Qian,Douglas F Covey
Mingxing Qian
We report an efficient synthesis of cyclopenta[b]phenanthrenes functionalized at C-3 and C-8 from an optically pure Hajos-Parrish ketone. The key step is a neutral alumina catalyzed Michael addition of a Hajos-Parrish ketone derivative (4) ...
Organocatalytic High Enantioselective Synthesis of β-Formyl-α-hydroxyphosphonates [0.03%]
高对映选择性有机催化合成β-甲醛-α-羟基磷onic酸酯类化合物
Sandun Perera,Vijaya Kumar Naganaboina,Long Wang et al.
Sandun Perera et al.
The cross aldol reaction between enolizable aldehydes and α-ketophosphonates was achieved for the first time by using 9-amino-9-deoxy-epi-quinine as the catalyst. β-Formyl-α-hydroxyphosphonates were obtained in high to excellent enantios...
Expanding the Scope of Biocatalysis: Oxidative Biotransformations on Solid-Supported Substrates [0.03%]
扩大生物催化的范围：固载底物的氧化生物转化反应
Sarah J Brooks,Lydie Coulombel,Disha Ahuja et al.
Sarah J Brooks et al.
Oxidative biocatalytic reactions were performed on solid-supported substrates, thus expanding the repertoire of biotransformations that can be carried out on the solid phase. Various phenylacetic and benzoic acid analogs were attached to co...
Palladium-Catalyzed Aryl Amination Reactions of 6-Bromo- and 6-Chloropurine Nucleosides [0.03%]
钯催化6-溴和6-氯嘌呤核苷的芳胺化反应
Paul F Thomson,Pallavi Lagisetty,Jan Balzarini et al.
Paul F Thomson et al.
Palladium-catalyzed C-N bond forming reactions of 6-bromo- as well as 6-chloropurine ribonucleosides and the 2'-deoxy analogues with aryl amines are described. Efficient conversions were observed with Pd(OAc)(2)/Xantphos/Cs(2)CO(3), in PhMe...
Bruce H Lipshutz,David W Chung,Brian Rich
Bruce H Lipshutz
Unsymmetrical di- and triarylamines can be formed under green chemistry conditions, taking advantage of micellar catalysis leading to palladium-catalyzed aminations at ambient temperatures in water as the only medium.
Gold(I)-Catalyzed Intramolecular Hydroamination of N-Allylic,N'-Aryl Ureas to form Imidazolidin-2-ones [0.03%]
金(I)催化N-烯丙基-N'-芳基尿素分子内的氢胺化反应形成咪唑烷-2-酮类化合物
Hao Li,Feijie Song,Ross A Widenhoefer
Hao Li
Treatment of N-allylic,N'-aryl ureas with a catalytic 1:1 mixture of di-tert-butyl-o-biphenylphoshphine gold(I) chloride and silver hexafluorophosphate (1 mol %) in chloroform at room temperature led to 5-exo hydroamination to form the corr...
Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition [0.03%]
基于Hsp90抑制的新型茋类衍生物抗肿瘤药物的高效合成
Xiaoguang Lei,Samuel J Danishefsky
Xiaoguang Lei
The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using "click chemistry." The preliminary biological ev...