The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups [0.03%]
酮类化合物与炔烃亲核试剂的不对称加成反应
Barry M Trost,Andrew H Weiss
Barry M Trost
Over the past decade, large strides have been achieved in the invention of methods for the direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral aldehydes, ketones, and imines. This review highlights a...
Jianwei Sun,Valerie A Keller,S Todd Meyer et al.
Jianwei Sun et al.
We describe the development of a silver-catalyzed carbonyl olefination employing electron rich siloxy alkynes. This process constitutes an efficient synthesis of trisubstituted unsaturated esters, and represents an alternative to the widely...
An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition [0.03%]
用于(-)-Phomactin A的ABD并环合成，含手性Rawal不对称Diels-Alder环加成反应
Ling-Feng You,Richard P Hsung,Aaron A Bedermann et al.
Ling-Feng You et al.
An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt. ...
Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations [0.03%]
钌催化下累积炔烃的环三聚化反应合成取代异吲哚酮类化合物
Robert W Foster,Christopher J Tame,Helen C Hailes et al.
Robert W Foster et al.
(Cyclooctadiene)(pentamethylcyclopentadiene)ruthenium chloride [Cp*RuCl(cod)] has been used to catalyze the regioselective cyclization of amide-tethered diynes with monosubstituted alkynes to give polysubstituted isoindolinones. Notably, th...
Highly(≥98%) Stereo- and Regioselective Trisubstituted Alkene Synthesis of Wide Applicability via 1-Halo-1-alkyne Hydroboration-Tandem Negishi-Suzuki Coupling or Organoborate Migratory Insertion Protocol [0.03%]
高立体(≥98%)、区域选择性三取代烯烃的广泛适用合成方法：通过1-卤代-炔烃硼化物-串联Negishi-Suzuki偶联或有机硼迁移插入体系实现
Shiqing Xu,Ching-Tien Lee,Honghua Rao et al.
Shiqing Xu et al.
(Z)-1-Halo-1-alkenylboranes (7), preparable in 82-90% yields as ≥98% isomerically pure compounds via hydroboration of 1-halo-1-alkynes, have been converted to a wide range of trisubstituted alkenes via three different routes in the tail-to...
Arylethyne Bromoboration-Negishi Coupling Route to E- or Z-Aryl-Substituted Trisubstituted Alkenes of ≥98% IsomericPurity. New Horizon in the Highly Selective Synthesis of Trisubstituted Alkenes [0.03%]
高选择性合成三取代烯烃的新领域：Arylethyne Bromoboration-Negishi Coupling Route通向E-或Z-芳基取代的三取代烯烃（≥98%立体纯度）之路
Chao Wang,Zhaoqing Xu,Tomas Tobrman et al.
Chao Wang et al.
The hitherto unprecedented palladium-catalyzed cross-coupling of (Z)-β-bromo-β-arylethenylboranes can be made to proceed satisfactorily through (1) the use of highly catalytically active bis(tri-tert-butylphosphine)palladium or dichloro[N...
Gold (III) Chloride-Catalyzed 6- endo- trig Oxa-Michael Addition Reactions for Diastereoselective Synthesis of Fused Tetrahydropyranones [0.03%]
金(III)氯化物催化6-endo-开环迈克加成反应实现氧代迈克尔加成反应的非对映选择性合成稠合四氢吡喃酮化合物
Jennifer Ciesielski,David Lebœuf,Harry A Stern et al.
Jennifer Ciesielski et al.
Alkynones were treated with boron trifluoride diethyl etherate to generate β-iodoallenolates, which underwent intramolecular aldol reactions to produce cycloalkenyl alcohols. Diastereoselective oxa-Michael ring closure could then be induce...
Palladium Catalyzed Cyclopropanation of Unsaturated Endoperoxides. A New Peroxide Preserving Reaction [0.03%]
钯催化不饱和内过氧化物的环丙烷化反应 过氧化物保护的新方法
Michael A Emerzian,William Davenport,Jiangao Song et al.
Michael A Emerzian et al.
Unsaturated bicyclic endoperoxides are efficiently cyclopropanated with excess diazomethane in the presence of catalytic Pd(OAc)2 in a stereoselective manner. This method represents a new peroxide preserving transformation. Whereas the unsa...
Combining Transition Metal Catalysis with Radical Chemistry: Dramatic Acceleration of Palladium-Catalyzed C-H Arylation with Diaryliodonium Salts [0.03%]
结合过渡金属催化的自由基化学：使用二芳基碘盐加速钯催化C-H烯基化反应
Sharon R Neufeldt,Melanie S Sanford
Sharon R Neufeldt
This paper describes a photoredox palladium/iridium-catalyzed C-H arylation with diaryliodonium reagents. Details of the reaction optimization, substrate scope, and mechanism are presented along with a comparison to a related method in whic...
Cinchona alkaloid catalyzed enantioselective amination of α,β-unsaturated ketones: an asymmetric approach to Δ2-pyrazolines [0.03%]
奎宁生物碱催化α,β不饱和酮的不对称胺化反应：合成Δ2-吡唑啉的新方法
Nathaniel R Campbell,Bingfeng Sun,Ravi P Singh et al.
Nathaniel R Campbell et al.
Δ2-Pyrazolines are of significant medicinal and synthetic interest due to their therapeutic properties and utility in the synthesis of 1,3-diamines, yet few asymmetric methods exist to prepare them. An unprecedented highly enantioselective...