Asymmetric Synthesis of β-Substituted α-Methylenebutyro- lactones via TRIP-Catalyzed Allylation: Mechanistic Studies and Application to the Synthesis of (S)-(-)-Hydroxymatairesinol [0.03%]
手性TRIP催化下β-取代α-甲基烯基丁内酯的不对称合成：机理研究及(S)-(−)-氢氧马苔树脂醇合成中的应用
Michael Fuchs,Markus Schober,Andreas Orthaber et al.
Michael Fuchs et al.
Asymmetric allylation of (hetero)aromatic aldehydes by a zinc(II)-allylbutyrolactone species catalyzed by a chiral BINOL-type phosphoric acid gave β-substituted α-methylenebutyrolactones in 68 to >99% ee and 52-91% isolated yield. DFT stu...
Stereoretentive Copper (II) Catalyzed Ritter Reactions of Secondary Cycloalkanols [0.03%]
手性铜(II)催化二级环烷醇的Ritter反应
Mohammed H Al-Huniti,Salvatore D Lepore
Mohammed H Al-Huniti
A Ritter-like coupling reaction of cyclic alcohols and both aryl and alkyl nitriles to form amides catalyzed by copper (II) triflate is described. These reactions proceed in good yields under mild and often solvent-free conditions. With 2- ...
The Pyridyldiisopropylsilyl Group: A Masked Functionality and Directing Group for Monoselective ortho-Acyloxylation and ortho-Halogenation Reactions of Arenes [0.03%]
吡啶基二异丙基硅烷基：一种苯环单选择性邻酰氧基化和邻卤代反应的导向基团及可脱除官能团
Chunhui Huang,Natalia Chernyak,Alexander S Dudnik et al.
Chunhui Huang et al.
A novel, easily removable and modifiable silicon-tethered pyridyldiisopropylsilyl directing group for C-H functionalizations of arenes has been developed. The installation of the pyridyldiisopropylsilyl group can efficiently be achieved via...
The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups [0.03%]
酮类化合物与炔烃亲核试剂的不对称加成反应
Barry M Trost,Andrew H Weiss
Barry M Trost
Over the past decade, large strides have been achieved in the invention of methods for the direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral aldehydes, ketones, and imines. This review highlights a...
Jianwei Sun,Valerie A Keller,S Todd Meyer et al.
Jianwei Sun et al.
We describe the development of a silver-catalyzed carbonyl olefination employing electron rich siloxy alkynes. This process constitutes an efficient synthesis of trisubstituted unsaturated esters, and represents an alternative to the widely...
An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition [0.03%]
用于(-)-Phomactin A的ABD并环合成，含手性Rawal不对称Diels-Alder环加成反应
Ling-Feng You,Richard P Hsung,Aaron A Bedermann et al.
Ling-Feng You et al.
An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt. ...
Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations [0.03%]
钌催化下累积炔烃的环三聚化反应合成取代异吲哚酮类化合物
Robert W Foster,Christopher J Tame,Helen C Hailes et al.
Robert W Foster et al.
(Cyclooctadiene)(pentamethylcyclopentadiene)ruthenium chloride [Cp*RuCl(cod)] has been used to catalyze the regioselective cyclization of amide-tethered diynes with monosubstituted alkynes to give polysubstituted isoindolinones. Notably, th...
Highly(≥98%) Stereo- and Regioselective Trisubstituted Alkene Synthesis of Wide Applicability via 1-Halo-1-alkyne Hydroboration-Tandem Negishi-Suzuki Coupling or Organoborate Migratory Insertion Protocol [0.03%]
高立体(≥98%)、区域选择性三取代烯烃的广泛适用合成方法：通过1-卤代-炔烃硼化物-串联Negishi-Suzuki偶联或有机硼迁移插入体系实现
Shiqing Xu,Ching-Tien Lee,Honghua Rao et al.
Shiqing Xu et al.
(Z)-1-Halo-1-alkenylboranes (7), preparable in 82-90% yields as ≥98% isomerically pure compounds via hydroboration of 1-halo-1-alkynes, have been converted to a wide range of trisubstituted alkenes via three different routes in the tail-to...
Arylethyne Bromoboration-Negishi Coupling Route to E- or Z-Aryl-Substituted Trisubstituted Alkenes of ≥98% IsomericPurity. New Horizon in the Highly Selective Synthesis of Trisubstituted Alkenes [0.03%]
高选择性合成三取代烯烃的新领域：Arylethyne Bromoboration-Negishi Coupling Route通向E-或Z-芳基取代的三取代烯烃（≥98%立体纯度）之路
Chao Wang,Zhaoqing Xu,Tomas Tobrman et al.
Chao Wang et al.
The hitherto unprecedented palladium-catalyzed cross-coupling of (Z)-β-bromo-β-arylethenylboranes can be made to proceed satisfactorily through (1) the use of highly catalytically active bis(tri-tert-butylphosphine)palladium or dichloro[N...
Gold (III) Chloride-Catalyzed 6- endo- trig Oxa-Michael Addition Reactions for Diastereoselective Synthesis of Fused Tetrahydropyranones [0.03%]
金(III)氯化物催化6-endo-开环迈克加成反应实现氧代迈克尔加成反应的非对映选择性合成稠合四氢吡喃酮化合物
Jennifer Ciesielski,David Lebœuf,Harry A Stern et al.
Jennifer Ciesielski et al.
Alkynones were treated with boron trifluoride diethyl etherate to generate β-iodoallenolates, which underwent intramolecular aldol reactions to produce cycloalkenyl alcohols. Diastereoselective oxa-Michael ring closure could then be induce...