Arylethyne Bromoboration-Negishi Coupling Route to E- or Z-Aryl-Substituted Trisubstituted Alkenes of ≥98% IsomericPurity. New Horizon in the Highly Selective Synthesis of Trisubstituted Alkenes [0.03%]
高选择性合成三取代烯烃的新领域：Arylethyne Bromoboration-Negishi Coupling Route通向E-或Z-芳基取代的三取代烯烃（≥98%立体纯度）之路
Chao Wang,Zhaoqing Xu,Tomas Tobrman et al.
Chao Wang et al.
The hitherto unprecedented palladium-catalyzed cross-coupling of (Z)-β-bromo-β-arylethenylboranes can be made to proceed satisfactorily through (1) the use of highly catalytically active bis(tri-tert-butylphosphine)palladium or dichloro[N...
Gold (III) Chloride-Catalyzed 6- endo- trig Oxa-Michael Addition Reactions for Diastereoselective Synthesis of Fused Tetrahydropyranones [0.03%]
金(III)氯化物催化6-endo-开环迈克加成反应实现氧代迈克尔加成反应的非对映选择性合成稠合四氢吡喃酮化合物
Jennifer Ciesielski,David Lebœuf,Harry A Stern et al.
Jennifer Ciesielski et al.
Alkynones were treated with boron trifluoride diethyl etherate to generate β-iodoallenolates, which underwent intramolecular aldol reactions to produce cycloalkenyl alcohols. Diastereoselective oxa-Michael ring closure could then be induce...
Palladium Catalyzed Cyclopropanation of Unsaturated Endoperoxides. A New Peroxide Preserving Reaction [0.03%]
钯催化不饱和内过氧化物的环丙烷化反应 过氧化物保护的新方法
Michael A Emerzian,William Davenport,Jiangao Song et al.
Michael A Emerzian et al.
Unsaturated bicyclic endoperoxides are efficiently cyclopropanated with excess diazomethane in the presence of catalytic Pd(OAc)2 in a stereoselective manner. This method represents a new peroxide preserving transformation. Whereas the unsa...
Combining Transition Metal Catalysis with Radical Chemistry: Dramatic Acceleration of Palladium-Catalyzed C-H Arylation with Diaryliodonium Salts [0.03%]
结合过渡金属催化的自由基化学：使用二芳基碘盐加速钯催化C-H烯基化反应
Sharon R Neufeldt,Melanie S Sanford
Sharon R Neufeldt
This paper describes a photoredox palladium/iridium-catalyzed C-H arylation with diaryliodonium reagents. Details of the reaction optimization, substrate scope, and mechanism are presented along with a comparison to a related method in whic...
Cinchona alkaloid catalyzed enantioselective amination of α,β-unsaturated ketones: an asymmetric approach to Δ2-pyrazolines [0.03%]
奎宁生物碱催化α,β不饱和酮的不对称胺化反应：合成Δ2-吡唑啉的新方法
Nathaniel R Campbell,Bingfeng Sun,Ravi P Singh et al.
Nathaniel R Campbell et al.
Δ2-Pyrazolines are of significant medicinal and synthetic interest due to their therapeutic properties and utility in the synthesis of 1,3-diamines, yet few asymmetric methods exist to prepare them. An unprecedented highly enantioselective...
Effects of Methyl Substituents on the Activity and Enantioselectivity of Homobenzotetramisole-Based Catalysts in the Kinetic Resolution of Alcohols [0.03%]
甲基取代对同系苯并四氨咪唑类催化剂在手性仲醇动态动力学拆分中的活性及enantioselectivity的影响研究
Yuhua Zhang,Vladimir B Birman
Yuhua Zhang
Substitution of the tetrahydropyrimidine ring in enantioselective acyl transfer catalyst homobenzotetramisole (HBTM) 6 with methyl groups exerts a dramatic influence on its performance in the kinetic resolution of secondary alcohols. Syn-3-...
Catalytic Asymmetric Synthesis of Branched Chiral Allylic Phenyl Ethers from (E)-Allylic Alcohols [0.03%]
E型烯丙醇的催化不对称合成分支型手性烯丙基苯醚化合物
Angela C Olson,Larry E Overman,Helen F Sneddon et al.
Angela C Olson et al.
The first di-μ-amidate dipalladium complexes and a new di-μ-carboxylate dipalladium complex of the COP (cobalt oxazoline palladacycle) palladium(II) catalyst family are reported and characterized crystallographically. The di-μ-amidate co...
A Novel Bis-Thiourea Organocatalyst for the Asymmetric Aza-Henry Reaction [0.03%]
用于不对称氮亨利反应的新型双硫脲有机催化剂
Constantinos Rampalakos,William D Wulff
Constantinos Rampalakos
A novel bis-thiourea BINAM-based catalyst for the asymmetric aza-Henry reaction has been developed. This catalyst promotes the reaction of N-Boc imines with nitroalkanes to afford β-nitroamines with good yields and high enantioselectivitie...
Substituent Effect on the Formation and Their Reactivity of Platinum Carbenoids [0.03%]
取代基效应与铂碳烯的生成及其反应性关系研究
Eun Jin Cho,Daesung Lee
Eun Jin Cho
A propargylic ester containing a propargylic alkoxy group has been observed to preferentially undergo [1,2]-acyl shift over [1,3]-shift. In addition, the complementary and contrasting reactivity of vinyl vs. alkynyl platinum carbenoids has ...
Efficient and General Synthesis of 3-Aminoindolines and 3-Aminoindoles via Copper-Catalyzed Three Component Coupling Reaction [0.03%]
一种有效的合成3-氨基吲哚啉和3-氨基吲哚的三组分偶联反应方法
Dmitri Chernyak,Natalia Chernyak,Vladimir Gevorgyan
Dmitri Chernyak
An efficient three component coupling (TCC) reaction toward a variety of 3-aminoindoline and 3-aminoindole derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction between 2-aminobenzal...