Silver-Promoted Benzannulations of Siloxy Alkynes with Pyridinium and Isoquinolinium Salts [0.03%]
银催化的硅氧基炔烃与吡啶𬭩盐和异喹啉𬭩盐的苯并化反应
Jaime R Cabrera-Pardo,David I Chai,Sergey A Kozmin
Jaime R Cabrera-Pardo
We describe the development of efficient benzannulations of siloxy alkynes with pyridinium and isoquinolinium salts. Such reactions are successfully promoted by a stoichiometric amount of silver(I) benzolate under mild reaction conditions. ...
Leloir Glycosyltransferases and Natural Product Glycosylation: Biocatalytic Synthesis of the C-Glucoside Nothofagin, a Major Antioxidant of Redbush Herbal Tea [0.03%]
莱洛尔糖基转移酶和天然产物糖基化：生物催化合成卡伦茶主要抗氧化组分诺斯酚苷的C-糖苷骨架
Linda Bungaruang,Alexander Gutmann,Bernd Nidetzky
Linda Bungaruang
Nothofagin is a major antioxidant of redbush herbal tea and represents a class of bioactive flavonoid-like C-glycosidic natural products. We developed an efficient enzymatic synthesis of nothofagin based on a one-pot coupled glycosyltransfe...
Asymmetric Synthesis of β-Substituted α-Methylenebutyro- lactones via TRIP-Catalyzed Allylation: Mechanistic Studies and Application to the Synthesis of (S)-(-)-Hydroxymatairesinol [0.03%]
手性TRIP催化下β-取代α-甲基烯基丁内酯的不对称合成：机理研究及(S)-(−)-氢氧马苔树脂醇合成中的应用
Michael Fuchs,Markus Schober,Andreas Orthaber et al.
Michael Fuchs et al.
Asymmetric allylation of (hetero)aromatic aldehydes by a zinc(II)-allylbutyrolactone species catalyzed by a chiral BINOL-type phosphoric acid gave β-substituted α-methylenebutyrolactones in 68 to >99% ee and 52-91% isolated yield. DFT stu...
Stereoretentive Copper (II) Catalyzed Ritter Reactions of Secondary Cycloalkanols [0.03%]
手性铜(II)催化二级环烷醇的Ritter反应
Mohammed H Al-Huniti,Salvatore D Lepore
Mohammed H Al-Huniti
A Ritter-like coupling reaction of cyclic alcohols and both aryl and alkyl nitriles to form amides catalyzed by copper (II) triflate is described. These reactions proceed in good yields under mild and often solvent-free conditions. With 2- ...
The Pyridyldiisopropylsilyl Group: A Masked Functionality and Directing Group for Monoselective ortho-Acyloxylation and ortho-Halogenation Reactions of Arenes [0.03%]
吡啶基二异丙基硅烷基：一种苯环单选择性邻酰氧基化和邻卤代反应的导向基团及可脱除官能团
Chunhui Huang,Natalia Chernyak,Alexander S Dudnik et al.
Chunhui Huang et al.
A novel, easily removable and modifiable silicon-tethered pyridyldiisopropylsilyl directing group for C-H functionalizations of arenes has been developed. The installation of the pyridyldiisopropylsilyl group can efficiently be achieved via...
The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups [0.03%]
酮类化合物与炔烃亲核试剂的不对称加成反应
Barry M Trost,Andrew H Weiss
Barry M Trost
Over the past decade, large strides have been achieved in the invention of methods for the direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral aldehydes, ketones, and imines. This review highlights a...
Jianwei Sun,Valerie A Keller,S Todd Meyer et al.
Jianwei Sun et al.
We describe the development of a silver-catalyzed carbonyl olefination employing electron rich siloxy alkynes. This process constitutes an efficient synthesis of trisubstituted unsaturated esters, and represents an alternative to the widely...
An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition [0.03%]
用于(-)-Phomactin A的ABD并环合成，含手性Rawal不对称Diels-Alder环加成反应
Ling-Feng You,Richard P Hsung,Aaron A Bedermann et al.
Ling-Feng You et al.
An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt. ...
Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations [0.03%]
钌催化下累积炔烃的环三聚化反应合成取代异吲哚酮类化合物
Robert W Foster,Christopher J Tame,Helen C Hailes et al.
Robert W Foster et al.
(Cyclooctadiene)(pentamethylcyclopentadiene)ruthenium chloride [Cp*RuCl(cod)] has been used to catalyze the regioselective cyclization of amide-tethered diynes with monosubstituted alkynes to give polysubstituted isoindolinones. Notably, th...
Highly(≥98%) Stereo- and Regioselective Trisubstituted Alkene Synthesis of Wide Applicability via 1-Halo-1-alkyne Hydroboration-Tandem Negishi-Suzuki Coupling or Organoborate Migratory Insertion Protocol [0.03%]
高立体(≥98%)、区域选择性三取代烯烃的广泛适用合成方法：通过1-卤代-炔烃硼化物-串联Negishi-Suzuki偶联或有机硼迁移插入体系实现
Shiqing Xu,Ching-Tien Lee,Honghua Rao et al.
Shiqing Xu et al.
(Z)-1-Halo-1-alkenylboranes (7), preparable in 82-90% yields as ≥98% isomerically pure compounds via hydroboration of 1-halo-1-alkynes, have been converted to a wide range of trisubstituted alkenes via three different routes in the tail-to...