Stereocontrol in Palladium-Catalyzed Propargylic Substitutions: Kinetic Resolution to give Enantioenriched 1,5-Enynes and Propargyl Acetates [0.03%]
钯催化炔丙基取代反应中的立体控制：动力学拆分生成富集对映体的1,5-enediyne和炔丙酯类化合物
Michael J Ardolino,Meredith S Eno,James P Morken
Michael J Ardolino
Kinetic resolution during the catalytic allyl-propargyl cross-coupling with chiral starting materials can be accomplished with a chiral Palladium catalyst. These reactions offer ready access to enantiomerically enriched enyne products from ...
Palladium-Catalyzed Decarbonylative Dehydration of Fatty Acids for the Production of Linear Alpha Olefins [0.03%]
钯催化脂肪酸脱碳酰化脱水生产线性α烯烃反应
Yiyang Liu,Kelly E Kim,Myles B Herbert et al.
Yiyang Liu et al.
A highly efficient palladium-catalyzed decarbonylative dehydration reaction of carboxylic acids is reported. This method transforms abundant and renewable even-numbered natural fatty acids into valuable and expensive odd-numbered alpha olef...
A General and Practical Palladium-Catalyzed Direct α-Arylation of Amides with Aryl Halides [0.03%]
一种通用的钯催化酰胺与aryl halide的直接α-芳基化反应方法
Bing Zheng,Tiezheng Jia,Patrick J Walsh
Bing Zheng
An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented. The palladium catalyst is supported by Kwong's indole-based phosphine ligand and provides monoa...
Synthesis and Suzuki-Miyaura Cross-Coupling of Enantioenriched Secondary Potassium β-Trifluoroboratoamides: Catalytic, Asymmetric Conjugate Addition of Bisboronic Acid and Tetrakis(dimethylamino)diboron to α, β-Unsaturated Carbonyl Compounds [0.03%]
富氟手性β-三氟硼酸金属有机导向的钾化胺
Gary A Molander,Steven R Wisniewski,Mona Hosseini-Sarvari
Gary A Molander
Enantioenriched potassium β-trifluoroboratoamides have been synthesized via an asymmetric, copper-catalyzed 1,4-addition of tetrahydroxydiboron (BBA) and tetrakis(dimethylamino)diboron to α,β-unsaturated amides. These dibora reagents pro...
Rhodium-Catalyzed Asymmetric 1,4-Additions, in Water at Room Temperature, with In-Flask Catalyst Recycling [0.03%]
在室温水中高效催化环加成反应及催化剂就地回收法
Bruce H Lipshutz,Nicholas A Isley,Ralph Moser et al.
Bruce H Lipshutz et al.
Using the newly introduced designer surfactant polyethyleneglycol ubiquinol sebacate (PQS), as the platform for micellar catalysis, nonracemic BINAP has been covalently attached and rhodium(I) inserted to form PQS-BINAP-Rh. This species, th...
Silver-Promoted Benzannulations of Siloxy Alkynes with Pyridinium and Isoquinolinium Salts [0.03%]
银催化的硅氧基炔烃与吡啶𬭩盐和异喹啉𬭩盐的苯并化反应
Jaime R Cabrera-Pardo,David I Chai,Sergey A Kozmin
Jaime R Cabrera-Pardo
We describe the development of efficient benzannulations of siloxy alkynes with pyridinium and isoquinolinium salts. Such reactions are successfully promoted by a stoichiometric amount of silver(I) benzolate under mild reaction conditions. ...
Leloir Glycosyltransferases and Natural Product Glycosylation: Biocatalytic Synthesis of the C-Glucoside Nothofagin, a Major Antioxidant of Redbush Herbal Tea [0.03%]
莱洛尔糖基转移酶和天然产物糖基化：生物催化合成卡伦茶主要抗氧化组分诺斯酚苷的C-糖苷骨架
Linda Bungaruang,Alexander Gutmann,Bernd Nidetzky
Linda Bungaruang
Nothofagin is a major antioxidant of redbush herbal tea and represents a class of bioactive flavonoid-like C-glycosidic natural products. We developed an efficient enzymatic synthesis of nothofagin based on a one-pot coupled glycosyltransfe...
Asymmetric Synthesis of β-Substituted α-Methylenebutyro- lactones via TRIP-Catalyzed Allylation: Mechanistic Studies and Application to the Synthesis of (S)-(-)-Hydroxymatairesinol [0.03%]
手性TRIP催化下β-取代α-甲基烯基丁内酯的不对称合成：机理研究及(S)-(−)-氢氧马苔树脂醇合成中的应用
Michael Fuchs,Markus Schober,Andreas Orthaber et al.
Michael Fuchs et al.
Asymmetric allylation of (hetero)aromatic aldehydes by a zinc(II)-allylbutyrolactone species catalyzed by a chiral BINOL-type phosphoric acid gave β-substituted α-methylenebutyrolactones in 68 to >99% ee and 52-91% isolated yield. DFT stu...
Stereoretentive Copper (II) Catalyzed Ritter Reactions of Secondary Cycloalkanols [0.03%]
手性铜(II)催化二级环烷醇的Ritter反应
Mohammed H Al-Huniti,Salvatore D Lepore
Mohammed H Al-Huniti
A Ritter-like coupling reaction of cyclic alcohols and both aryl and alkyl nitriles to form amides catalyzed by copper (II) triflate is described. These reactions proceed in good yields under mild and often solvent-free conditions. With 2- ...
The Pyridyldiisopropylsilyl Group: A Masked Functionality and Directing Group for Monoselective ortho-Acyloxylation and ortho-Halogenation Reactions of Arenes [0.03%]
吡啶基二异丙基硅烷基：一种苯环单选择性邻酰氧基化和邻卤代反应的导向基团及可脱除官能团
Chunhui Huang,Natalia Chernyak,Alexander S Dudnik et al.
Chunhui Huang et al.
A novel, easily removable and modifiable silicon-tethered pyridyldiisopropylsilyl directing group for C-H functionalizations of arenes has been developed. The installation of the pyridyldiisopropylsilyl group can efficiently be achieved via...