Metal-Free Preparation of Cycloalkyl Aryl Sulfides via Di-tert-butyl Peroxide-Promoted Oxidative C(sp3)[BOND]H Bond Thiolation of Cycloalkanes [0.03%]
通过二叔丁基过氧化物促进的氧化脱氢硫化茋
Jincan Zhao,Hong Fang,Jianlin Han et al.
Jincan Zhao et al.
A concise thiolation of C(sp3)-H bond of cycloalkanes with diaryl disulfides in the presence of oxidant of di-tert-butylperoxide (DTBP) has been developed. This reaction without using any of metal catalyst, tolerates varieties of disulfides...
6-Azabicyclo[3.2.1]octanes Via Copper-Catalyzed Enantioselective Alkene Carboamination [0.03%]
铜催化内消旋烯烃亚胺的环化反应生成6-氮杂双环[3.2.1]辛烷类化合物
Barbara J Casavant,Azade S Hosseini,Sherry R Chemler
Barbara J Casavant
Bridged bicyclic rings containing nitrogen heterocycles are important motifs in bioactive small organic molecules. An enantioselective copper-catalyzed alkene carboamination reaction that creates bridged heterocycles is reported herein. Two...
Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation [0.03%]
由RNC-X配位引发的异氰化合物催化插入和缩合反应
Suravi Chakrabarty,Shruti Choudhary,Arpit Doshi et al.
Suravi Chakrabarty et al.
Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with metal and non-metal catalysts provides rapid access to a large array of complex ni...
Regioselective Benzylation of 2-Deoxy-2-Aminosugars Using Crown Ethers: Application to a Shortened Synthesis of Hyaluronic Acid Oligomers [0.03%]
冠醚用于2-脱氧-2-氨基糖区域选择性苄基化：透明质酸寡聚物简明合成中的应用
Chinmoy Mukherjee,Lin Liu,Nicola L B Pohl
Chinmoy Mukherjee
The combination of benzyl bromide, sodium hydroxide and 15-crown-5 in tetrahydrofuran is shown to be an efficient method for installing benzyl groups at both the 4- and 6-positions regioselectively directly from peracetylated N-trichloroace...
Transition-Metal-Free ipso-Functionalization of Arylboronic Acids and Derivatives [0.03%]
无过渡金属参与的芳基硼酸和衍生物的ipso官能化反应
Chen Zhu,John R Falck
Chen Zhu
Arylboronic acids and their derivatives have been widely exploited as important synthetic precursors in organic synthesis, materials science, and pharmaceutical development. In addition to numerous applications in transition-metal-mediated ...
Triarylphosphine Ligands with Hemilabile Alkoxy Groups. Ligands for Nickel(II)-Catalyzed Olefin Dimerization Reactions. Hydrovinylation of Vi-nylarenes, 1,3-Dienes, and Cycloisomerization of 1,6-Dienes [0.03%]
含半配位的烷氧基的三芳基膦配体。镍(II)催化烯烃二聚反应中的配体。乙烯基芳烃、1,3-丁二烯和1,6-丁二烯环异构化的加氢反应
Souvagya Biswas,Aibin Zhang,Balaram Raya et al.
Souvagya Biswas et al.
Substitution of one of the phenyl groups of triphenylphosphine with a 2-benzyloxy-, 2-benzyloxymethyl- or 2-benzyloxyethyl-phenyl moiety results in a set of simple ligands, which exhibit strikingly different behaviour in various nickel(II)-...
Biomimetic Aerobic C-H Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes [0.03%]
室温下 cyclic enaminone 的仿生有氧C-H olefination反应：用于合成1,3,5-三取代苯的尝试
Yi-Yun Yu,Gunda I Georg
Yi-Yun Yu
A green and mild protocol for the dehydrogenative olefination of cyclic enaminones was devised via palladium catalysis at room temperature using oxygen as the terminal oxidant. The synthetic utility of the olefinated cyclic enaminones affor...
Taku Kitanosono,Shū Kobayashi
Taku Kitanosono
Mukaiyama aldol reactions in aqueous media have been surveyed. While the original Mukaiyama aldol reactions entailed stoichiometric use of Lewis acids in organic solvents under strictly anhydrous conditions, Mukaiyama aldol reactions in aqu...
Gold Catalysed Redox Synthesis of Imidazo[1,2- a]pyridine using Pyridine N-Oxide and Alkynes [0.03%]
金催化氧化还原反应合成吡啶诺克和炔氢的Imidazo[1,2-a]pyridine
Eric P A Talbot,Melodie Richardson,Jeffrey M McKenna et al.
Eric P A Talbot et al.
A mild, catalytic, atom economical synthesis of imidazo[1,2-a]pyridines has been developed: catalytic PicAuCl2 in the presence of an acid produces a range imidazo[1,2-a]pyridines in good yield. This strategy is mild and forseen to be of par...
Asymmetric Aldol Reaction of 3-Acetyl-2 H-chromen-2-ones and Isatins Catalyzed by a Bifunctional Quinidine Urea Catalyst [0.03%]
脯氨酸催化的异山酮和异丁酸衍生的α,β-不饱和酮与异atin的不对称aldol反应
Santhi Abbaraju,John Cong-Gui Zhao
Santhi Abbaraju
The asymmetric aldol reaction of 3-acetyl-2H-chromen-2-ones and isatins has been realized by using a bifunctional quinidine-derived urea as the catalyst. The corresponding 3-hydroxyoxindole derivatives containing a 2H-chromen-2-one moiety w...