Simplified Preparation of Trialkylvinylsilanes via the Silyl-Heck Reaction Utilizing a Second Generation Catalyst [0.03%]
通过二代催化剂利用硅代 Heck 反应简化三烷氧基乙烯基硅烷的制备
Jesse R McAtee,Sarah B Krause,Donald A Watson
Jesse R McAtee
Recently we reported a second-generation ligand, bis(3,5-di-tert-butylphenyl)(tert-butyl)phosphine, for the preparation of allyl silanes using the silyl-Heck reaction. We now show that this new ligand also provides superior reactivity in th...
Rhodium(I)-Catalyzed Intermolecular Hydroacylation of α-Keto Amides and Isatins with Non-Chelating Aldehydes [0.03%]
非螯合醛的α-酮酰胺和异丁酸酯的铑(I)催化分子间羟基酰化反应
Kevin G M Kou,Lauren E Longobardi,Vy M Dong
Kevin G M Kou
The application of the bidentate, electron-rich bisphosphine ligand, 1,3-bis(dicyclohexyl)phosphine-propane (dcpp), in rhodium(I)-catalyzed intermolecular ketone hydroacylation is herein described. Isatins and α-keto amides are shown to un...
An Efficient Protocol for the Palladium-catalyzed Asymmetric Decarboxylative Allylic Alkylation Using Low Palladium Concentrations and a Palladium(II) Precatalyst [0.03%]
一种高效的钯催化非对映选择性脱羧烯丙基烷基化反应协议，使用低浓度的钯和钯(ii)预催化剂
Alexander N Marziale,Douglas C Duquette,Robert A Craig nd et al.
Alexander N Marziale et al.
Enantioselective catalytic allylic alkylation for the synthesis of 2-alkyl-2-allylcycloalkanones and 3,3-disubstituted pyrrolidinones, piperidinones and piperazinones has been previously reported by our laboratory. The efficient constructio...
Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis [0.03%]
酶促动态还原动力学拆分法(DYRKR)在立体选择性合成中的应用
Gregory A Applegate,David B Berkowitz
Gregory A Applegate
Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry and have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrol...
Palladium-Catalyzed Alkene Carboamination Reactions of Electron-Poor Nitrogen Nucleophiles [0.03%]
电子贫乏氮亲核试剂的烯烃卡保氨钯催化反应
Luke J Peterson,John P Wolfe
Luke J Peterson
Modified reaction conditions that facilitate Pd-catalyzed alkene carboamination reactions of electron-deficient nitrogen nucleophiles are reported. Pent-4-enylamine derivatives bearing N-tosyl or N-trifluoroacetyl groups are coupled with ar...
Diastereoselective Oxidative C-N/C-O and C-N/C-N Bond Formation Tandems Initiated by Visible Light: Synthesis of Fused N-Arylindolines [0.03%]
可见光引发的选择性合成稠合N-芳基吲哚啉
Scott A Morris,Theresa H Nguyen,Nan Zheng
Scott A Morris
The synthesis of fused N-arylindolines using visible light photoredox catalysis has been developed. We previously described that photogenerated amine radical cations generate substituted indoles through an intermediate benzylic carbocation....
A Synergistic Combinatorial and Chiroptical Study of Peptide Catalysts for Asymmetric Baeyer-Villiger Oxidation [0.03%]
手性和组合技术在多肽Baeyer-Villiger催化剂的不对称氧化反应中的协同研究
Michael W Giuliano,Chung-Yon Lin,David K Romney et al.
Michael W Giuliano et al.
We report an approach to the asymmetric Baeyer-Villiger oxidation utilizing bioinformatics-inspired combinatorial screening for catalyst discovery. Scaled-up validation of our on-bead efforts with a circular dichroism-based assay of alcohol...
Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled Compounds [0.03%]
钯催化合成2,3-取代苯并呋喃：氘代化合物合成的新方法
Soumitra Agasti,Soham Maity,Kalman J Szabo et al.
Soumitra Agasti et al.
Palladium-catalyzed oxidative annulations between phenols and alkenylcarboxylic acids produced a library of benzofuran compounds. Depending on the nature of the substitution of the phenol precursor, either 2,3-dialkylbenzofurans or 2-alkyl-...
Regioselective Enzymatic β-Carboxylation of para-Hydroxy- styrene Derivatives Catalyzed by Phenolic Acid Decarboxylases [0.03%]
酚酸脱羧酶催化对羟基苯乙烯衍生物区域选择性β-羧化反应
Christiane Wuensch,Tea Pavkov-Keller,Georg Steinkellner et al.
Christiane Wuensch et al.
We report on a 'green' method for the utilization of carbon dioxide as C1 unit for the regioselective synthesis of (E)-cinnamic acids via regioselective enzymatic carboxylation of para-hydroxystyrenes. Phenolic acid decarboxylases from bact...
Nitrile as Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases [0.03%]
天冬氨酸衍生物催化下β-氰基丙酸的不对称生物还原反应中硝基的活化作用研究
Christoph K Winkler,Dorina Clay,Nikolaus G Turrini et al.
Christoph K Winkler et al.
Asymmetric bioreduction of an (E)-β-cyano-2,4-dienoic acid derivative by ene-reductases allowed a shortened access to a precursor of pregabalin [(S)-3-(aminomethyl)-5-methylhexanoic acid] possessing the desired configuration in up to 94% c...