Palladium-Catalyzed Alkene Carboamination Reactions of Electron-Poor Nitrogen Nucleophiles [0.03%]
电子贫乏氮亲核试剂的烯烃卡保氨钯催化反应
Luke J Peterson,John P Wolfe
Luke J Peterson
Modified reaction conditions that facilitate Pd-catalyzed alkene carboamination reactions of electron-deficient nitrogen nucleophiles are reported. Pent-4-enylamine derivatives bearing N-tosyl or N-trifluoroacetyl groups are coupled with ar...
Diastereoselective Oxidative C-N/C-O and C-N/C-N Bond Formation Tandems Initiated by Visible Light: Synthesis of Fused N-Arylindolines [0.03%]
可见光引发的选择性合成稠合N-芳基吲哚啉𬭩盐的方法研究
Scott A Morris,Theresa H Nguyen,Nan Zheng
Scott A Morris
The synthesis of fused N-arylindolines using visible light photoredox catalysis has been developed. We previously described that photogenerated amine radical cations generate substituted indoles through an intermediate benzylic carbocation....
A Synergistic Combinatorial and Chiroptical Study of Peptide Catalysts for Asymmetric Baeyer-Villiger Oxidation [0.03%]
手性和组合技术在多肽Baeyer-Villiger催化剂的不对称氧化反应中的协同研究
Michael W Giuliano,Chung-Yon Lin,David K Romney et al.
Michael W Giuliano et al.
We report an approach to the asymmetric Baeyer-Villiger oxidation utilizing bioinformatics-inspired combinatorial screening for catalyst discovery. Scaled-up validation of our on-bead efforts with a circular dichroism-based assay of alcohol...
Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled Compounds [0.03%]
钯催化合成2,3-取代苯并呋喃：氘代化合物合成的新方法
Soumitra Agasti,Soham Maity,Kalman J Szabo et al.
Soumitra Agasti et al.
Palladium-catalyzed oxidative annulations between phenols and alkenylcarboxylic acids produced a library of benzofuran compounds. Depending on the nature of the substitution of the phenol precursor, either 2,3-dialkylbenzofurans or 2-alkyl-...
Regioselective Enzymatic β-Carboxylation of para-Hydroxy- styrene Derivatives Catalyzed by Phenolic Acid Decarboxylases [0.03%]
酚酸脱羧酶催化对羟基苯乙烯衍生物区域选择性β-羧化反应
Christiane Wuensch,Tea Pavkov-Keller,Georg Steinkellner et al.
Christiane Wuensch et al.
We report on a 'green' method for the utilization of carbon dioxide as C1 unit for the regioselective synthesis of (E)-cinnamic acids via regioselective enzymatic carboxylation of para-hydroxystyrenes. Phenolic acid decarboxylases from bact...
Nitrile as Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases [0.03%]
天冬氨酸衍生物催化下β-氰基丙酸的不对称生物还原反应中硝基的活化作用研究
Christoph K Winkler,Dorina Clay,Nikolaus G Turrini et al.
Christoph K Winkler et al.
Asymmetric bioreduction of an (E)-β-cyano-2,4-dienoic acid derivative by ene-reductases allowed a shortened access to a precursor of pregabalin [(S)-3-(aminomethyl)-5-methylhexanoic acid] possessing the desired configuration in up to 94% c...
Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael-Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis [0.03%]
酶催化连续的动态共价系统拆分合成不对称硫代环烷烃
Yan Zhang,Pornrapee Vongvilai,Morakot Sakulsombat et al.
Yan Zhang et al.
Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the ...
A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes [0.03%]
用于合成1,2-双(烷基磷烷亚甲基)化合物的简便方法
Laurence R Doyle,Alex Heath,Choon Heng Low et al.
Laurence R Doyle et al.
1,2-Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi-g...
Enzymatic Redox Cascade for One-Pot Synthesis of Uridine 5'-Diphosphate Xylose from Uridine 5'-Diphosphate Glucose [0.03%]
基于尿苷二磷酸葡萄糖的一锅法合成尿苷二磷酸木糖的酶促氧化还原级联反应
Thomas Eixelsberger,Bernd Nidetzky
Thomas Eixelsberger
Synthetic ways towards uridine 5'-diphosphate (UDP)-xylose are scarce and not well established, although this compound plays an important role in the glycobiology of various organisms and cell types. We show here how UDP-glucose 6-dehydroge...
Dissecting Anion Effects in Gold(I)-Catalyzed Intermolecular Cycloadditions [0.03%]
金(I)催化介观环加成中阴离子效应的剖析
Anna Homs,Carla Obradors,David Lebœuf et al.
Anna Homs et al.
From a series of gold complexes of the type [t-BuXPhosAu(MeCN)]X (X=anion), the best results in intermolecular gold(I)-catalyzed reactions are obtained with the complex with the bulky and soft anion BAr4F- [BAr4F-=3,5-bis(trifluoromethyl)ph...