Human placenta-derived mesenchymal stem cells and islet-like cell clusters generated from these cells as a novel source for stem cell therapy in diabetes [0.03%]
人胎盘间充质干细胞及其分化诱导而来的类似胰岛细胞团作为糖尿病治疗的干细胞新来源的研究
Sachin Kadam,Sudhakar Muthyala,Prabha Nair et al.
Sachin Kadam et al.
Placental tissue holds great promise as a source of cells for regenerative medicine due to its plasticity, and easy availability. Human placenta-derived mesenchymal stem cells (hPDMSCs) have the potential to differentiate into insulin-produ...
Pere Santamaria,Ignacio Rodriguez-Piza,Xavier Clemente-Casares et al.
Pere Santamaria et al.
Objective: Human embryonic stem (hES) cells can be differentiated into pancreatic endoderm structures in vitro. The study was performed to determine whether induced pluripotent stem (iPS) cells can be differentiated into ...
Bone marrow-derived stem cell transplantation for the treatment of insulin-dependent diabetes [0.03%]
骨髓干细胞移植治疗胰岛素依赖性糖尿病
Carmen Fotino,Camillo Ricordi,Vincenzo Lauriola et al.
Carmen Fotino et al.
The bone marrow is an invaluable source of adult pluripotent stem cells, as it gives rise to hematopoietic stem cells, endothelial progenitor cells, and mesenchymal cells, amongst others. The use of bone marrow-derived stem cell (BMC) trans...
Valeria Sordi,Lorenzo Piemonti
Valeria Sordi
Allogeneic islet transplantation serves as a source of insulin-secreting beta-cells for the maintenance of normal glucose levels and treatment of diabetes. However, limited availability of islets, high rates of islet graft failure, and the ...
Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration [0.03%]
成人胰岛α细胞：一种新的β细胞再生细胞来源
Cheng-Ho Chung,Fred Levine
Cheng-Ho Chung
Beta-cell deficit is the major pathological feature in type 1 and type 2 diabetes patients, and plays a key role in disease progression. In principle, beta-cell regeneration can occur by replication of pre-existing beta-cells, or by beta-ce...
The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement [0.03%]
胰腺和其他器官的组织干细胞的探索及其在β细胞替代中的应用
Isabelle Houbracken,Luc Bouwens
Isabelle Houbracken
Adult stem cell research has drawn a lot of attention by many researchers, due to its medical hope of cell replacement or regenerative therapy for diabetes patients. Despite the many research efforts to date, there is no consensus on the ex...
Hirofumi Noguchi
Hirofumi Noguchi
Patients with type 1 diabetes, and most patients with type 2 diabetes, have associated hyperglycemia due to the absence or reduction of insulin production by pancreatic β-cells. Surgical resection of the pancreas may also cause insulin-dep...
The new generation of beta-cells: replication, stem cell differentiation, and the role of small molecules [0.03%]
β细胞的新一代：增殖、干细胞分化及小分子的作用
Malgorzata Borowiak
Malgorzata Borowiak
Diabetic patients suffer from the loss of insulin-secreting β-cells, or from an improper working β-cell mass. Due to the increasing prevalence of diabetes across the world, there is a compelling need for a renewable source of cells that c...
Generation of insulin-producing cells from pluripotent stem cells: from the selection of cell sources to the optimization of protocols [0.03%]
从干细胞选择到优化诱导方案——诱导多能干细胞分化为胰岛素生成细胞的研究进展
Chee-Gee Liew
Chee-Gee Liew
The pancreas arises from Pdx1-expressing progenitors in developing foregut endoderm in early embryo. Expression of Ngn3 and NeuroD1 commits the cells to form endocrine pancreas, and to differentiate into subsets of cells that constitute isl...