Generation of insulin-producing cells from pluripotent stem cells: from the selection of cell sources to the optimization of protocols
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The pancreas arises from Pdx1-expressing progenitors in developing foregut endoderm in early embryo. Expression of Ngn3 and NeuroD1 commits the cells to form endocrine pancreas, and to differentiate into subsets of cells that constitute islets of Langerhans. ... ...
