Katharina Wolff,Ronja Friedhoff,Friderieke Schwarzer et al.
Katharina Wolff et al.
With an ever increasing amount of research data available, it becomes constantly more important to possess data literacy skills to benefit from this valuable resource. An integrative course was developed to teach students the fundamentals o...
Accurate noise-robust classification of Bacillus species from MALDI-TOF MS spectra using a denoising autoencoder [0.03%]
基于MALDI-TOF质谱的芽孢杆菌种类噪声鲁棒分类及其去噪自动编码器实现
Yulia E Uvarova,Pavel S Demenkov,Irina N Kuzmicheva et al.
Yulia E Uvarova et al.
Bacillus strains are ubiquitous in the environment and are widely used in the microbiological industry as valuable enzyme sources, as well as in agriculture to stimulate plant growth. The Bacillus genus comprises several closely related gro...
Reconstruction of the regulatory hypermethylation network controlling hepatocellular carcinoma development during hepatitis C viral infection [0.03%]
丙型肝炎病毒感染过程中调控肝癌发生发展的表观遗传网络重塑
Evgeniya A Antropova,Tamara M Khlebodarova,Pavel S Demenkov et al.
Evgeniya A Antropova et al.
Hepatocellular carcinoma (HCC) has been associated with hepatitis C viral (HCV) infection as a potential risk factor. Nonetheless, the precise genetic regulatory mechanisms triggered by the virus, leading to virus-induced hepatocarcinogenes...
Yuriy L Orlov,Ming Chen,Nikolay A Kolchanov et al.
Yuriy L Orlov et al.
STARGATE-X: a Python package for statistical analysis on the REACTOME network [0.03%]
基于REACTOME网络的统计分析Python工具包STARGATE-X
Andrea Marino,Blerina Sinaimeri,Enrico Tronci et al.
Andrea Marino et al.
Many important aspects of biological knowledge at the molecular level can be represented by pathways. Through their analysis, we gain mechanistic insights and interpret lists of interesting genes from experiments (usually omics and function...
RNAcode_Web - Convenient identification of evolutionary conserved protein coding regions [0.03%]
RNAcode_Web：方便识别进化保守的蛋白质编码区
John Anders,Peter F Stadler
John Anders
The differentiation of regions with coding potential from non-coding regions remains a key task in computational biology. Methods such as RNAcode that exploit patterns of sequence conservation for this task have a substantial advantage in c...
SnakeLines: integrated set of computational pipelines for sequencing reads [0.03%]
SnakeLines：面向测序读段的计算流程集成工具集
Jaroslav Budiš,Werner Krampl,Marcel Kucharík et al.
Jaroslav Budiš et al.
With the rapid growth of massively parallel sequencing technologies, still more laboratories are utilising sequenced DNA fragments for genomic analyses. Interpretation of sequencing data is, however, strongly dependent on bioinformatics pro...
Discovering NDM-1 inhibitors using molecular substructure embeddings representations [0.03%]
基于分子亚结构嵌入表示的NDM-1抑制剂的发现
Thomas Papastergiou,Jérôme Azé,Sandra Bringay et al.
Thomas Papastergiou et al.
NDM-1 (New-Delhi-Metallo-β-lactamase-1) is an enzyme developed by bacteria that is implicated in bacteria resistance to almost all known antibiotics. In this study, we deliver a new, curated NDM-1 bioactivities database, along with a set o...
Enhanced identification of membrane transport proteins: a hybrid approach combining ProtBERT-BFD and convolutional neural networks [0.03%]
改进的膜转运蛋白识别方法：结合ProtBERT-BFD和卷积神经网络的混合方法
Hamed Ghazikhani,Gregory Butler
Hamed Ghazikhani
Transmembrane transport proteins (transporters) play a crucial role in the fundamental cellular processes of all organisms by facilitating the transport of hydrophilic substrates across hydrophobic membranes. Despite the availability of num...
Carlos A C Bastos,Vera Afreixo,João M O S Rodrigues et al.
Carlos A C Bastos et al.
This work aims to describe the observed enrichment of inverted repeats in the human genome; and to identify and describe, with detailed length profiles, the regions with significant and relevant enriched occurrence of inverted repeats. The ...