Designing an optimized theta-defensin peptide for HIV therapy using in-silico approaches [0.03%]
利用计算机模拟方法设计优化的 Theta-防御素肽用于HIV治疗
Zahra Mosalanejad,Seyed Nooreddin Faraji,Mohammad Reza Rahbar et al.
Zahra Mosalanejad et al.
The glycoproteins 41 (gp41) of human immunodeficiency virus (HIV), located on the virus's external surface, form six-helix bundles that facilitate viral entry into the host cell. Theta defensins, cyclic peptides, inhibit the formation of th...
Immunoinformatics-guided design of a multiepitope peptide vaccine targeting the receptor-binding domain of SARS-CoV-2 spike glycoprotein: insights from Indonesian samples [0.03%]
基于免疫信息学指导的针对SARS-CoV-2刺突糖蛋白受体结合域的多表位肽疫苗设计：来自印度尼西亚样本的启示
Irvan Faizal,Darrian Chandra,Tarwadi et al.
Irvan Faizal et al.
The emergence of new variants of SARS-CoV-2, including Alpha, Beta, Gamma, Delta, Omicron variants, and XBB sub-variants, contributes to the number of coronavirus cases worldwide. SARS-CoV-2 is a positive RNA virus with a genome of 29.9 kb ...
MiRNA target enrichment analysis of co-expression network modules reveals important miRNAs and their roles in breast cancer progression [0.03%]
基于共表达网络模块的miRNA靶基因富集分析揭示了乳腺癌进展中重要miRNA及其功能
Mohammad Javad Bazyari,Seyed Hamid Aghaee-Bakhtiari
Mohammad Javad Bazyari
Breast cancer has the highest incidence and is the fifth cause of death in cancers. Progression is one of the important features of breast cancer which makes it a life-threatening cancer. MicroRNAs are small RNA molecules that have pivotal ...
Exploring the therapeutic potential of Asparagus africanus in polycystic ovarian syndrome: a computational analysis [0.03%]
计算分析非洲芦笋治疗多囊卵巢综合征潜力的研究
Sania Riaz,Fatima Haider,Rizwan- Ur-Rehman et al.
Sania Riaz et al.
PCOS is a multifaceted condition characterized by ovarian abnormalities, metabolic disorders, anovulation, and hormonal imbalances. In response to the growing demand for treatments with fewer side effects, the exploration of herbal-origin d...
TREMSUCS-TCGA - an integrated workflow for the identification of biomarkers for treatment success [0.03%]
TREMSUCS-TCGA——治疗成功的生物标志物识别的集成工作流程
Gabor Balogh,Natasha Jorge,Célia Dupain et al.
Gabor Balogh et al.
Many publicly available databases provide disease related data, that makes it possible to link genomic data to medical and meta-data. The cancer genome atlas (TCGA), for example, compiles tens of thousand of datasets covering a wide array o...
Ion channel classification through machine learning and protein language model embeddings [0.03%]
基于机器学习和蛋白质语言模型嵌入的离子通道分类
Hamed Ghazikhani,Gregory Butler
Hamed Ghazikhani
Ion channels are critical membrane proteins that regulate ion flux across cellular membranes, influencing numerous biological functions. The resource-intensive nature of traditional wet lab experiments for ion channel identification has led...
International symposium on integrative bioinformatics 2024 - editorial [0.03%]
2024年整合生物信息学国际研讨会-编者按
Can Türker,Christian Panse,Bjorn Sommer et al.
Can Türker et al.
Integrative Bioinformatics faces the challenge of integrating, aligning, modelling, and simulating data in a coherent fashion to gain deeper insights into complex biological systems. This special issue of the Journal of Integrative Bioinfor...
A roadmap for a middleware as a federation service for integrative data retrieval of agricultural data [0.03%]
一种农业数据集成检索的中间件融合服务技术路线图
Jorge García Brizuela,Carsten Scharfenberg,Carmen Scheuner et al.
Jorge García Brizuela et al.
Agriculture is confronted with several challenges such as climate change, the loss of biodiversity and stagnating productivity. The massive increasing amount of data and new digital technologies promise to overcome them, but they necessitat...
The potential of Mitragyna speciosa leaves as a natural source of antioxidants for disease prevention [0.03%]
kratom叶作为抗氧化剂预防疾病的潜力
Ihsanul Arief,Gagus Ketut Sunnardianto,Syahrul Khairi et al.
Ihsanul Arief et al.
Mitragyna speciosa is famous for its addictive effect. On the other hand, this plant has good potential as an antioxidant agent, and so far, it was not explicitly explained what the most contributing compound in the leaves to that activity ...
MCMVDRP: a multi-channel multi-view deep learning framework for cancer drug response prediction [0.03%]
一种基于多通道、多视角深度学习框架的癌症药物反应预测方法
Xiangyu Li,Xiumin Shi,Yuxuan Li et al.
Xiangyu Li et al.
Drug therapy remains the primary approach to treating tumours. Variability among cancer patients, including variations in genomic profiles, often results in divergent therapeutic responses to analogous anti-cancer drug treatments within the...