Refinement and 3D-QSAR Studies of Inhibitors of Cyclophilin A Containing Amide Linker [0.03%]
含酰胺连接体的环化蛋白A抑制剂的优化及3D定量结构活性关系研究
Feng Fan,Jin Zhu,Shuaishuai Ni et al.
Feng Fan et al.
Cyclophilin A (CypA) is a ubiquitous cellular enzyme playing essential role in many biological processes, and the discovery of CypA inhibitor is now of special interest in the treatment of immunological disorders. In this work, molecular mo...
CoMFA/CoMSIA/HQSAR and Docking Study of the Binding Mode of Selective Cyclooxygenase (COX-2) Inhibitors [0.03%]
选择性环氧化酶(COX-2)抑制剂的相互作用模式的CoMFA/CoMSIA/HQSAR及对接研究
Haifeng Chen,Qiang Li,Xiaojun Yao et al.
Haifeng Chen et al.
The intermolecular interaction between four types of anti-inflammatory inhibitors (oxazoles, pyrazoles, pyrroles and imidazoles) and COX-2 receptor was studied. The results of docking suggest that they have similar interaction mechanism. Th...