CHRONIC NEONATAL DIAZOXIDE THERAPY IS NOT ASSOCIATED WITH ADVERSE EFFECTS [0.03%]
慢性新生霉素 Diazoxide治疗无不良影响
Michele M Cox,Christopher C Wendler,Ildiko Erdelyi et al.
Michele M Cox et al.
Diazoxide is an ATP-sensitive potassium channel (KATP) agonist that has been shown to neuroprotective effects. These observations raise the possibility that diazoxide may have potential as a therapeutic agent for other applications. This st...
Palmitate-Induced Translocation of Caveolin-3 and Endothelial Nitric Oxide Synthase in Cardiomyocytes [0.03%]
棕榈酸诱导的心肌细胞 caveolin-3 和内皮型一氧化氮合酶的重分布
Catherine J Knowles,Megan Dionne,Martina Cebova et al.
Catherine J Knowles et al.
PROBLEM STATEMENT: Palmitate is a known cardiac lipotoxin that blunts cardiomyocyte contractile function and induces apoptosis, likely via accumulation of the lipotoxic ceramide. Ceramide is a sphingolipid and localizes to caveolae, which a...
Stephanie Cabarcas,Kounosuke Watabe,Laura Schramm
Stephanie Cabarcas
PROBLEM STATEMENT: RNA polymerase III (RNA pol III) is responsible for transcribing many of the small structural RNA molecules involved in RNA processing and protein translation, thereby regulating the growth rate of a cell. RNA pol III tra...