IL-17A, IL-17F, and IL-23 in Patients with Rheumatoid Arthritis [0.03%]
类风湿关节炎患者的IL-17A、IL-17F和IL-23
N A Lapkina,A A Baranov,O P Rechkina et al.
N A Lapkina et al.
The aim of the study was to determine the clinical and diagnostic value of IL-17A, IL-17F, and IL-23 in RA patients in the advanced stage of the disease. MATERIALS AND METHODS: . We examined 154 patients with a reliable diagnosis of RA acco...
Changes in the Repertoire of Extracellular Vesicles Secreted by Skin Keratinocytes by the Human Protein SLURP-2 [0.03%]
人类蛋白质SLURP-2对皮肤角质细胞分泌的胞外囊泡谱系的影响
T Y Gornostaeva,O V Shlepova,I D Kukushkin et al.
T Y Gornostaeva et al.
Extracellular vesicles secreted by keratinocytes are involved in intercellular interactions and contain various proteins, mRNA and miRNA, lipids, due to which they can activate cell migration and proliferation. The secreted human protein SL...
Quantitative Assessment of T-Regulatory Cell Population and FOXP3 Gene Expression in Chronically Exposed Residents of the Urals Region [0.03%]
乌拉尔地区居民慢性暴露人群定量评估调节性T细胞亚群及FOXP3基因表达量
A I Kotikova,V S Nikiforov,E A Blinova et al.
A I Kotikova et al.
The objective is to conduct a pilot study on the quantity of regulatory T-cells (Treg) in the peripheral blood and to assess transcriptional activity of FOXP3 gene in chronically exposed persons. Materials and methods. The study included 77...
D A Skvortsov,I V Zhirkina,D A Ipatova et al.
D A Skvortsov et al.
To search for substances selectively acting on tumor cells, phenotypic screening in a coculture of tumor cells with non-tumor cells was used in the work. The compound STOCK7S-36520, selectively cytotoxic in the coculture of breast tumor cel...
Increasing the Accumulation of Modular Nanotransporters in Mouse Tumors by Attaching Polyethylene Glycol to These Nanotransporters with the Possibility of Its Release into the Tumors [0.03%]
通过将PEG连接到纳米运输器并使其在肿瘤内释放来增加肿瘤内模块化纳米运输器积累的可能性
Yu V Khramtsov,A V Ulasov,T A Slastnikova et al.
Yu V Khramtsov et al.
Previously, polypeptide constructs-modular nanotransporters (MNTs)-were created to deliver biologically active molecules into the nuclei of melanoma cells. In the present work, polyethylene glycol (PEG) molecules were attached to them at th...
Types of Pesticides Interaction in Mixtures: Results of Inhibitory Assay [0.03%]
混配农药交互作用类型：基于抑制试验的结果分析
E N Esimbekova,D V Satir,V A Kratasyuk
E N Esimbekova
Enzymatic inhibitory assay based on the coupled enzyme system NAD(P)·H:FMN oxidoreductase and luciferase (Red + Luc), originally developed for environmental monitoring of soils, water, and air, is proposed as a method for evaluating change...
Development of an Anchor Bispecific Nanoantibody to Improve the Efficiency of Antigen Immobilization and Detection in a Well of a Polystyrene Plate [0.03%]
一种改进抗原在聚苯乙烯孔中固定和检测效率的锚定双特异性纳米抗体的开发
S V Tillib,M V Panasyuk,O S Goryaynova et al.
S V Tillib et al.
Immunoassay (IA) methods performed in the wells of a polystyrene microplate are the basis of diagnostic studies. In the "sandwich" IA, a fundamentally important initial stage is the immobilization of anchor antibodies in the well of the pla...
Effect of Hesperidin on Lipid Profile, Inflammation and Apoptosis in Experimental Diabetes [0.03%]
芸香苷对糖尿病小鼠脂代谢、炎症因子及细胞凋亡的影响研究
Kenan Yıldızhan,Mehmet Hafit Bayir,Zübeyir Huyut et al.
Kenan Yıldızhan et al.
In recent years, therapeutic approaches against diabetes-induced liver damage have attracted great interest. Studies indicate the anticarcinogenic, anti-inflammatory, antioxidant, and lipid-lowering potential of hesperidin (HESP), a flavono...
Modular Nanotransporters Containing Keap1 Monobodies Are Capable of Reducing the Toxic Effect of Acetaminophen on the Liver of Mice [0.03%]
含有Keap1单域蛋白的纳米载体能够降低乙酰氨基酚对小鼠肝脏的毒性作用
Yu V Khramtsov,A A Rosenkranz,A V Ulasov et al.
Yu V Khramtsov et al.
Previously, we created a modular nanotransporter (MNT) containing a monobody to Keap1, an intracellular protein inhibitor of the Nrf2 transcription factor that controls cellular protection from oxidative stress and is capable of interacting...
Gallic Acid Enhances Cisplatin-induced Death of Human Laryngeal Cancer Cells by Activating the TRPM2 Channel [0.03%]
没食子酸通过激活TRPM2通道增强白屈菜酸用于人类喉癌细胞诱导死亡的作用研究
Yener Yazgan,Ramazan Cinar
Yener Yazgan
Cisplatin (CIS) is widely used in the treatment of laryngeal cancer, one of the most common and lethal cancers. However, it is not a satisfactory chemotherapeutic agent. Therefore, there is a need to identify new agents, such as gallic acid...