Achieving Maximum Efficiency of A549 Cell Transfection with a Plasmid Delivered by Polyethylenimine-Based Polyplexes [0.03%]
基于聚乙烯亚胺的polyplex传递的质粒转染A549细胞的最佳效率
Y V Khramtsov,G P Georgiev,A S Sobolev
Y V Khramtsov
Effective gene therapy depends on efficient delivery of genetic material into cells. Polyplexes, complexes of positively charged polymers and DNA, are a common non-viral delivery system. In this study, polyplexes were formed using a plasmid...
Polymorphism of hOGG1 Gene and Susceptibility to Malignant Neoplasms in People Affected by Long-Term Low-Dose-Rate Exposure [0.03%]
长期低剂量照射人群hOGG1基因多态性与恶性肿瘤易感性的关系研究
M A Yanishevskaya,E A Blinova,E A Shishkina et al.
M A Yanishevskaya et al.
In the previous study [1], we showed an increased risk of malignant neoplasms in carriers of the minor allele rs1052133*G of the hOGG1 gene who were affected by chronic radiation exposure at a wide range of doses (up to 3507 mGy to the red ...
Association between the rs1052133 Polymorphism of the OGG1 Gene and the Risk of Malignant Neoplasm Development in People Chronically Exposed to Radiation [0.03%]
OGG1基因rs1052133多态性与放射线慢性暴露人群恶性肿瘤风险的相关性分析
M A Yanishevskaya,E A Blinova,A V Korechenkova et al.
M A Yanishevskaya et al.
Genetic predisposition without doubt is one of the risk factors of cancer initiation. It is known that single nucleotide polymorphisms (SNP) of genes that maintain the genome stability, including SNP of DNA repair, may contribute to the ini...
Modular Nanotransporters Containing Anti-PSMA Nanobodies Are Able to Penetrate into the Nuclei of Prostate Cancer Cells [0.03%]
含有抗PSMA纳米抗体的模块化纳米运输器能够穿透前列腺癌细胞的细胞核
Y V Khramtsov,A V Ulasov,T A Slastnikova et al.
Y V Khramtsov et al.
Polypeptide modular nanotransporters (MNTs) were engineered as a targeted delivery platform for prostate cancer cells. The constructs integrate a ligand module to facilitate specific cellular binding and internalization, and a nuclear local...
A New Model for the Transmembrane Heterocomplex of Hemagglutinin HA and Ionic Channel M2 Proteins in Influenza A Virus [0.03%]
流感病毒血凝素HA和离子通道M2蛋白跨膜异源复合的新模型研究
O P Zhirnov,A I Chernyshova
O P Zhirnov
The lipid envelope of the influenza A virus contains two major types of protein spikes formed by the transmembrane hemagglutinin trimers (HA, MW 80 kDa) and neuraminidase tetramers (NA, MW 55 kDa), in quantities of 500 and 120, respectively...
Effect of Low Doses of Accelerated Carbon Ions with Energy of 450 MeV/Nucleon on Adaptive Response and Genetic Instability in Two Generations of Mice [0.03%]
低剂量加速碳粒子（450MeV/nucleon）照射对小鼠两代自适应反应和遗传不稳定性的效应研究
V E Balakin,O M Rozanova,T A Belyakova et al.
V E Balakin et al.
The patterns of radiation adaptive response (RAR) induction and transgenerational genomic instability in mice following exposure to carbon ions (12C) with a linear energy transfer (LET) of ~39 keV/μm and to X‑rays with a LET of ~2 keV/μm...
Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts [0.03%]
激光合成的硼纳米颗粒在肿瘤细胞和成纤维细胞中的吸收和保留
A I Kasatova,K S Kuzmina,P A Kotelnikova et al.
A I Kasatova et al.
Boron Neutron Capture Therapy (BNCT) is one of the innovative methods for treating oncological diseases. Its selectivity is based on the targeted delivery of the boron-10 isotope to tumor cells, followed by neutron irradiation, the 10B(n, ...
Development of an Approach for Parasegment-Specific Labeling of Nuclei in Drosophila melanogaster Embryos [0.03%]
果蝇胚胎中特定细胞核的谱段特异性标记方法的开发
I O Deriglazova,O V Kyrchanova,P G Georgiev et al.
I O Deriglazova et al.
Effective approaches for selecting nuclei in which a gene of interest is in an active state are necessary for studying spatial organization and gene expression regulation. In this work, a novel two-component genetic system was created for t...
A Bacterial Bioluminescent System as a Tool for Monitoring Biogenic Aldehydes [0.03%]
一种细菌生物发光系统作为监测生物生成甲醛的工具
A S Shcheglov,S A Lukyanov,I V Yampolsky
A S Shcheglov
Aliphatic aldehydes are involved in many important biological processes, but detection of them at low concentrations requires expensive laboratory equipment and labor-intensive analytical methods. Typically, chromatographic and chromatograp...
Efficacy and Safety of Long-term Administration of Various Doses of Colchicine in Patients with Gout [0.03%]
长期不同剂量使用秋水仙碱治疗痛风的疗效和安全性
M S Eliseev,M N Chikina,Y I Kuzmina et al.
M S Eliseev et al.
to compare the efficacy and safety of different doses of colchicine (0.5 mg/day vs. 1.0 mg/day) used for the prevention of arthritis attacks in gout patients during the initiation of urate-lowering therapy. ...