Fluorescence in situ hybridization supplements to conventional karyotype for detecting aberration of chromosome 5, 7, or 17 in newly diagnosed acute myeloid leukemia [0.03%]
急性髓系白血病新诊断病例5号、7号或17号染色体异常的检测：除常规核型分析外补充使用荧光原位杂交技术
Qiuyun Fang,Kunpeng Luo,Miao Yang et al.
Qiuyun Fang et al.
Objectives: To investigate the clinical significance of Fluorescence in situ hybridization (FISH) in detecting aberration of chromosome 5, 7, or 17 in newly diagnosed acute myeloid leukemia (AML) patients. ...
Ying Zhang,Yankun Yang,Yiwen Du et al.
Ying Zhang et al.
Objective: This review aims to summarize current progress in targeted therapy for acute myeloid leukemia (AML) with KMT2A rearrangement (KMT2Ar). This subtype of AML often shows resistance to chemotherapy and has a poor p...
Title: allogeneic peripheral blood stem cell transplantation for Myeloid sarcoma: a single-center experience [0.03%]
异基因外周血干细胞移植治疗粒细胞肉瘤的单中心报告
Dewan Zhao,Wenbin Cao,Gang Li et al.
Dewan Zhao et al.
Background: Myeloid sarcoma (MS) is a rare extramedullary manifestation of myeloid neoplasms and usually has poorer outcomes than acute myeloid leukemia without extramedullary disease. Allogeneic hematopoietic stem cell t...
Regulated expression of miR-99a and miR-100 relates clinical and prognostic parameters of acute myeloid leukemia [0.03%]
miR-99a和miR-100的表达量与急性髓系白血病临床及预后参数关系的研究
Chao Ding,Haiping Dai,Xiaolei Ren et al.
Chao Ding et al.
Background: Acute myeloid leukemia (AML) is a genetic disorder caused by translocations or mutations that disrupt hematopoietic function and lead to malignant transformation. In recent years, microRNA-99a and miR-100 have...
TMEM91::TAL1 Fusion gene in a middle-aged female with rapid MDS to secondary AML progression: a case report [0.03%]
一例中年女性TMEM91::TAL1融合基因继发急性髓系白血病的病例报告
Jiayi Huang,Man Wang,Zhiyu Zhang et al.
Jiayi Huang et al.
Objective: TMEM91::TAL1 fusion has been identified in glioblastoma but has never been documented in hematologic malignancies. We document the first presentation of the TMEM91::TAL1 fusion in a myelodysplastic syndrome (MD...
Effect of metabolic syndrome on prognosis in patients with peripheral T-cell lymphoma [0.03%]
代谢综合征对周围T细胞淋巴瘤患者预后的影响
Shi-Qi Gao,Hong-Bin Li,Ming-Zhe Yang et al.
Shi-Qi Gao et al.
Objectives: Peripheral T-cell lymphoma (PTCL) is characterized by significant heterogeneity and poor prognosis, with its high mortality rate remaining an unresolved challenge in clinical treatment. Recent studies have est...
Construction of a deep learning model and identification of BSG, PPARD, and SLC16A8 expression as potential indicators in the context of strategies for precision therapy to acute myeloid leukemia [0.03%]
深度学习模型的构建及其在急性髓系白血病精准治疗策略背景下识别BSG、PPARD和SLC16A8表达为潜在指标的研究
Yongyu Chen,Bin Liang,Ruilin He et al.
Yongyu Chen et al.
Objective: Acute myeloid leukemia (AML) exhibits significant heterogeneity and aggressiveness. This study aimed to investigate T cell heterogeneity in the AML tumor microenvironment using single-cell RNA sequencing (scRNA...
Active Epstein-Barr virus infection and its association with multiple myeloma: evidence from a meta-analytical perspective [0.03%]
活动性EB病毒感染及其与多发性骨髓瘤关系的荟萃分析证据
Zhimei Wu,Huiye Yang,Yongrong Lai
Zhimei Wu
Objectives: To clarify the association between active Epstein-Barr virus (EBV) infection and the risk of multiple myeloma (MM), given longstanding uncertainty regarding EBV's etiologic contribution to plasma cell malignan...
Lihui Qian,Pei Zhang,Ting Chen et al.
Lihui Qian et al.
Background: Ewing sarcoma breakpoint region 1(EWSR1) rearrangements have been repeatedly observed in acute myeloid leukemia (AML). However, the clinical impact of EWSR1 expression is still unclear in AML. Therefore, we ex...
DKK3 as a novel biomarker for risk stratification in pediatric acute lymphoblastic leukemia [0.03%]
DKK3作为儿童急性淋巴细胞白血病预后分层的新生物标志物
WenPeng Wang,Feng Zhu,Pei Li et al.
WenPeng Wang et al.
Introduction: Aberrant Wnt signaling drives oncogenesis. DKK proteins, key extracellular regulators of Wnt pathway, play critical roles in tumor suppression or promotion. ...