Leukemia-derived exosomes induce immunosuppression of dendritic cell function via TGFB2-MRPL58 axis [0.03%]
白血病源外泌体通过TGFB2-MRPL58轴诱导树突状细胞免疫抑制功能增强
Jinglong Lv,Yang Tao,Hui Zhong et al.
Jinglong Lv et al.
Objectives: To elucidate the mechanisms by which leukemia-derived exosomes induce immunosuppression in dendritic cells (DCs) and identify potential therapeutic targets. ...
Molecular and clinical characterization of -α4.2 subtypes in Shenzhen, Southern China [0.03%]
中国南部深圳地区-α4.2亚型的分子及临床特征分析
Lijuan Wang,Yaqin Song,Hui Gao et al.
Lijuan Wang et al.
Objectives: The 4.2-kb deletion (-α4.2) is a common cause of α-thalassemia in southern China. However, the molecular characteristics and clinical phenotypes of its subtypes remain incompletely characterized. This study ...
The efficacy and safety of CAR-T therapy in relapsed or refractory multiple myeloma patients: a systematic review and meta-analysis [0.03%]
CAR-T疗法治疗复发或难治多发性骨髓瘤疗效和安全性的系统评价和meta分析
Yiwei Zhou,Xueqi Xie,Kai Feng et al.
Yiwei Zhou et al.
Objectives: The introduction of novel therapies has markedly improved the prognosis of multiple myeloma (MM), yet relapse remains common. For patients with relapsed or refractory multiple myeloma (RRMM), immunotherapy - particularly chimeri...
CIRC_0000075 targeting MIR-218-5P is involved in the prognosis and mechanism of acute myeloid leukemia [0.03%]
靶向MIR-218-5P的CIRC_0000075与急性髓系白血病的预后及机制有关
Anni Xu,Ling Wang,Yuan Li et al.
Anni Xu et al.
Objectives: To investigate to investigate the role of circ_0000075 levels and its regulatory mechanism in patients with acute myeloid leukemia (AML). Meth...
Serum gamma-glutamyl transpeptidase/albumin ratio in patients with acute myeloid leukemia: a new perspective on prognostic assessment [0.03%]
急性髓系白血病患者血清γ-谷氨酰转肽酶/白蛋白比值：预后评估的新视角
Min Song,Xiaoman Sun,Pengyu Wang et al.
Min Song et al.
Objectives: Evaluate the gamma-glutamyl transpeptidase-to-albumin ratio (GAR) as a prognostic biomarker in acute myeloid leukemia (AML). Methods: ...
The role of immune cells in multiple myeloma: a bidirectional Mendelian randomization study [0.03%]
遗传学随机对照研究揭示免疫细胞在多发性骨髓瘤中的作用
Peng Xu,Yanxia Wang,Yongjun Hu et al.
Peng Xu et al.
Objectives: Prior research has highlighted immune cells' critical role in multiple myeloma (MM) pathogenesis, yet the causal relationships between them have remained obscure. ...
Real-world clinical outcomes and treatment response in complement inhibitor experienced and naïve PNH patients prescribed pegcetacoplan in Europe and Canada [0.03%]
PEG-RALA临床治疗经验前后的PNH患者在欧洲和加拿大的真实世界疗效及治疗反应
Jens Panse,Juan Carlos Vallejo Llamas,Koo Wilson et al.
Jens Panse et al.
Objectives: This study investigated outcomes and response to pegcetacoplan in complement inhibitor naïve (CInaïve) and experienced (CIexp) PNH patients. ...
Application of single nucleotide polymorphism array (SNP array) derived median copy number state for monitoring the clonal burden of the chromosomal aberrations in myelodysplastic neoplasms [0.03%]
基于单核苷酸多态性阵列衍生的中位拷贝数状态在染色体异常克隆负荷监测中的应用——骨髓衰竭性疾病中的初步探索研究
Lili Song,Zhenxiu Guo,Kun Chi
Lili Song
Objectives: Our study integrates SNP array and metaphase cytogenetics (MC) to decode clonal architecture in myelodysplastic syndromes (MDS) and related disorders. ...
Correlation between epigenetic modifier gene mutations and prognosis of patients with acute lymphoblastic leukemia: a systematic review and meta-analysis [0.03%]
表观遗传学修饰基因突变与急性淋巴细胞白血病患者预后关联的系统评价和meta分析
Rui-Qi Wang,Bing Han,Hai-Yu Song et al.
Rui-Qi Wang et al.
The impact of epigenetic modifier gene mutations (EMMs) on the prognosis of patients with acute lymphoblastic leukemia (ALL) is controversial, which is unlike AML. A meta-analysis is needed to evaluate the prognostic value of EMMs in ALL. ...
Cyclosporine A improves survival in lower-risk hypoplastic myelodysplastic syndromes: a single-center retrospective study from China [0.03%]
环孢素A可改善低危伴造血细胞克隆增生性疾病的生存率：一项中国的单中心回顾性研究
Yumei Liu,Liyan Yang,Yansong Wei et al.
Yumei Liu et al.
Background: Hypoplastic myelodysplastic syndrome (hMDS) is an uncommon MDS subtype, accounting for approximately 10-15% of cases, characterized by bone marrow hypocellularity, severe cytopenias, and features of immune dys...