CHAF1A identified as a candidate biomarker and potential therapeutic target in Burkitt lymphoma through integrated bioinformatics and histopathological analysis [0.03%]
整合生物信息学和组织病理学分析鉴定CHAF1A为Burkitt淋巴瘤的潜在治疗靶点及候选标志物
Wen-Yuan Lin,Bei-Li Chen,Zhi-Mei Wu et al.
Wen-Yuan Lin et al.
Background: Burkitt lymphoma (BL) is a highly aggressive malignancy with limited effective treatments due to toxicity/resistance. Identifying and prioritizing candidate biomarkers and potential therapeutic targets from co...
Immune reconstitution and viral reactivation after allogeneic hematopoietic stem cell transplantation in hematologic malignancies [0.03%]
造血干细胞移植后免疫重建和病毒再激活
Muhammad Qaiser,Hao Zhou,Guangyu Zhou et al.
Muhammad Qaiser et al.
Objectives: To evaluate associations between post-transplant immune reconstitution, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) DNAemia/reactivation, and survival after allogeneic hematopoietic stem cell transplant...
Observational Study
Hematology (Amsterdam, Netherlands). 2026 Dec 31;31(1):2707676. DOI:10.1080/16078454.2026.2707676 2026
Polyclonal B-cell lymphocytosis: a rare, benign condition that mimics a chronic lymphoproliferative disorder [0.03%]
多克隆B细胞淋巴细胞增多症：一种罕见的良性疾病，类似于慢性淋巴增生性疾病
Emily Parkes,Pedro Martin-Cabrera,Hannah Creasey et al.
Emily Parkes et al.
Objectives: We report a case of Persistent polyclonal B-cell lymphocytosis (PPBL), a rare and benign lymphoproliferative disorder, to highlight the importance of recognising its characteristic features in order to avoid u...
Highly suppressive functional CCR7 low Treg subset cells may correlate with poor prognosis of B-ALL [0.03%]
功能低CCR7的Tregs细胞与B-ALL预后较差有关
Sui Songnan,Jiamian Zheng,Jing Lai et al.
Sui Songnan et al.
Background: Regulatory T cells (Tregs) may influence prognosis in leukemia. This study aimed to explore the effects and mechanisms of Treg subclusters on the prognosis in B-cell acute lymphoblastic leukemia (B-ALL) using ...
The role of von Willebrand factor in gastrointestinal angiodysplasia and obscure gi bleeding: a narrative review [0.03%]
血管性肠病和不明原因消化道出血的血管性血友病因子的作用：综述
Ojan Ghodsi,Ali Ghasemi,Saleh Ahangari
Ojan Ghodsi
Objective: Gastrointestinal bleeding (GIB) is a major cause of morbidity in von Willebrand disease (vWD), most commonly resulting from angiodysplasia. Current obscure gastrointestinal bleeding (OGIB) algorithms are primar...
Effectiveness and safety of brentuximab vedotin-containing regimen versus standard chemotherapy in relapsed or refractory Hodgkin lymphoma: a multicenter cohort study [0.03%]
关于复发或难治性霍奇金淋巴瘤患者使用贝林妥欧单抗方案与标准化疗疗效和安全性的多中心队列研究
Abdullah M Alrajhi,Bashayer Alshehri,Walaa A Alshahrani et al.
Abdullah M Alrajhi et al.
Objective: Hodgkin lymphoma (HL) constitutes 3.4% of all cancers in Saudi Arabia, with advanced-stage relapse rates reaching 40%. While the anti-CD30 agent brentuximab vedotin (BV) has established efficacy, local data are...
Temporal trends and global comparison of the burden of thalassemia in China: an analysis of the Global Burden Of Disease Study 2021 [0.03%]
中国地中海贫血疾病负担的时间趋势和全球比较：基于全球疾病负担研究2021的分析
Changqun He,Meiting Long,Yiming Yang et al.
Changqun He et al.
Objective: This study aims to analyze the temporal trends, age‒sex patterns, and disease burden of thalassemia in China from 1990 to 2021 using the Global Burden of Disease (GBD) 2021 data, so as to optimize resource all...
Integrated multi-omics analysis identifies prognostic risk genes and constructs a predictive signature in diffuse large B-cell lymphoma [0.03%]
集成多组学分析鉴定弥漫性大B细胞淋巴瘤的预后风险基因并构建预测标志物
Sufei Kuang,Qixin Liu
Sufei Kuang
Background: Diffuse large B-cell lymphoma (DLBCL) presents a complex etiology and challenging diagnosis. This study aims to investigate potential pathogenic genes. ...
Raloxifene inhibits the proliferation of pediatric acute myeloid leukemia by targeting the ANP32B gene and regulating C-MYC expression [0.03%]
雷洛昔芬通过靶向ANP32B基因并调节C-MYC表达来抑制儿童急性髓系白血病的增殖
Xiaomei Wan,Zhong Yu,Chengcheng Huang et al.
Xiaomei Wan et al.
Objective: Acute myeloid leukemia (AML) is a severe and life-threatening malignant disease of the hematopoietic system. Our previous research found that ANP32B is regulated by super enhancers in pediatric AML and regulate...
Characterization of a novel α-thalassemia deletion (Dongxing deletion; --DX) by CNV-seq in a Chinese female with Hb H disease: a case report [0.03%]
采用CNV-seq技术表征中国一名Hb H病女性中的一种新型α-地中海贫血缺失(DX缺失;-- DX):病例报告
Youqiong Li,Ting Qin,Liang Liang et al.
Youqiong Li et al.
Objective: This study was initiated to resolve a discrepancy between conventional genetic findings and clinical presentation in a proband with α-thalassemia. The initial genotype (-α4.2/-α4.2) was inconsistent with the...