Investigating the genetic basis of fibrotic pathway dysregulation in Dupuytren's contracture [0.03%]
杜普耶特伦病患者致密结缔组织纤维化途径失调的遗传学研究
Alvita Vilkeviciute-Petraite,Dovile Basalykiene,Migdolija Baltakyte et al.
Alvita Vilkeviciute-Petraite et al.
Purpose: Dupuytren's contracture (DC) is a common fibroproliferative disorder with strong genetic predisposition. This study aimed to investigate the association between genetic variants in key fibrotic pathways and DC su...
Kaempferol binds with NSUN2 to mediate RNA 5-methylcytosine modification of BMP2 in osteogenic differentiation [0.03%]
山柰酚通过与NSUN2结合介导骨形态发生蛋白BMP2的RNA 5-甲基胞嘧啶修饰以促进成骨分化
Nan Yu,Guanyi He,Rui Huang et al.
Nan Yu et al.
Purpose: This study aimed to investigate the effects and underlying mechanism of kaempferol (Kae) on osteogenic differentiation through 5-methylcytosine (m5C) modification in bone metabolism. ...
Overexpression of NSUN3 suppresses ferroptosis in osteoarthritis chondrocytes by reducing m5C modification and expression of PCBP1 mRNA [0.03%]
NSUN3过表达通过降低PCBP1 mRNA的m5C修饰和表达抑制骨关节炎软骨细胞铁死亡
Wuluhan Mahan,Yelinaer Ayiheng,Zengru Xie
Wuluhan Mahan
Purpose: Osteoarthritis (OA) is a degenerative joint disease, with chondrocyte ferroptosis a key pathogenic mechanism in its progression. The role of RNA 5-methylcytosine (m5C) modification in OA chondrocyte ferroptosis r...
EZH2 depletion blocks the proliferation and collagen deposition of keloid fibroblasts via ferroptosis [0.03%]
EZH2缺失通过铁死亡阻断瘢痕疙瘩成纤维细胞的增殖和胶原沉积
Hao Yang,Lei Zhang,Shuang Du et al.
Hao Yang et al.
Purpose: Benign fibroproliferative disorders known as keloids feature excessive fibroblast proliferation coupled with collagen accumulation, yet effective treatment remains lacking. Enhancer of zeste homolog 2 (EZH2) is i...
Static magnetic fields promote osteogenesis via the lncRNA Gas5/miR-182/PKR molecular axis in rat osteoblasts and femoral defect models [0.03%]
长链非编码RNA Gas5通过调节miR-182/PKR信号促进大鼠成骨细胞及其骨缺损模型成骨分化
Jun Guo,Guangning Long,Fen Liu et al.
Jun Guo et al.
Purpose: Static magneticfields (SMF) stimulate osteogenesis, but the underlying mechanismremains unclear. This study investigated whether the lncRNAGas5/miR-182/PKR axis mediates SMF-enhanced osteogenic differentiation an...
Rotenone impairs osteoclastogenesis by inhibiting cell migration: insights from machine learning [0.03%]
罗特诺通过抑制细胞迁移损害破骨细胞生成：来自机器学习的见解
Chongjie Zhu,Chi Zhang,Mingjuan Li et al.
Chongjie Zhu et al.
Purpose: The migration and fusion of osteoclast precursors (OCPs) are critical steps in osteoclastogenesis and require substantial energy. Although oxidative phosphorylation (OXPHOS) is generally considered the major path...
E3 ubiquitin ligase Peli3 regulates M2 macrophage-to-myofibroblast transition and fibrosis in wound healing via IRF4 [0.03%]
E3泛素连接酶Peli3通过IRF4调节伤口愈合中M2巨噬细胞向肌成纤维细胞的转化及纤维化现象
Jinglin Zhu,Fangning Zhao,Gao Zeng
Jinglin Zhu
Purpose: M2 macrophage-to-myofibroblast transformation (MMT) contributes to fibrosis. The role of interferon regulatory factor 4 (IRF4), a key transcription factor in M2 macrophage polarization, in M2 MMT remains unclear....
Elastic fiber-mediated hierarchical bundling of collagen fibers in subcutaneous fascia [0.03%]
弹性纤维介导的皮下筋膜中胶原纤维的分层聚集现象
Kenshi Togashi,Tetsuo Sakamoto,Masaya Ikeda et al.
Kenshi Togashi et al.
Purpose: We aimed to clarify the localization and hierarchical structural roles of elastic fibers in subcutaneous fascia and to determine their contribution to the mechanical properties of this tissue. ...
Camille Déchelette,Guillaume Bouguéon,Adrien Naveau
Camille Déchelette
Purpose: The objective of this study was to characterize the viscoelastic shear properties of gingival connective tissue under physiological conditions in humans and pigs. Porcine tissue is commonly used as a preclinical ...
Peptide p[63-82] induces transcriptomic alterations associated with processes involved in cartilage repair in osteoarthritic human chondrocytes [0.03%]
肽p[63-82]通过调节与软骨修复相关过程的基因表达诱导软骨细胞转录组改变以治疗骨关节炎
Jessica S J Steijns,Guus G H van den Akker,Tim J M Welting et al.
Jessica S J Steijns et al.
Purpose: Osteoarthritis is a degenerative joint disease that can currently only be treated by alleviating pain or, ultimately, by a total joint replacement. The bone morphogenetic protein 7-derived peptide p[63-82] offers...