GFPT1 facilitates immune escape in breast cancer by promoting the OGT-mediate O-GlcNAcylation of CD39 [0.03%]
GFPT1通过促进CD39的O-GlcNA酰化介导免疫逃逸以促进乳腺癌发展
Huifen Zhen,Haibo Yang,Yarong Yao
Huifen Zhen
Breast cancer (BC) remains a major cause of cancer-related mortality among women worldwide, with immune escape being a critical mechanism contributing to tumor progression and therapy resistance. Glutamine-fructose-6-phosphate transaminase ...
The role of IRF-1 in mediating T-cell immune imbalance in systemic lupus erythematosus and the construction of a diagnostic model [0.03%]
IRF-1在介导系统性红斑狼疮T细胞免疫失衡中的作用及诊断模型的建立
Zichen Huang,Cheng Zhao,Fang Qing et al.
Zichen Huang et al.
Systemic lupus erythematosus (SLE), characterized by immune dysregulation, urgently requires improved diagnostic tools and mechanistic insights. The role of interferon regulatory factor-1 (IRF-1) remains unclear. We integrated single-cell t...
CAR-T cell therapy for solid tumors: HIF-1α as a potential enhancement strategy [0.03%]
针对实体瘤的CAR-T细胞治疗：HIF-1α作为潜在增强策略
Hai Rong Li,Jie Xiong,Chun Hui Wang et al.
Hai Rong Li et al.
The advent of chimeric antigen receptor (CAR) T cell therapy has yielded transformative efficacy in hematological malignancies, yet its application in solid tumors remains constrained by the immunosuppressive tumor microenvironment (TME). C...
Single-cell transcriptomic analysis reveals T cell heterogeneity and metabolic reprogramming in human immune-mediated glomerulonephritis [0.03%]
单细胞转录组分析揭示了人类免疫介导的肾小球肾炎中T细胞异质性和代谢重编程
Jianbo Qing,Yiting Zhao,Wisit Cheungpasitporn et al.
Jianbo Qing et al.
Immune-mediated glomerulonephritis (IMGN) is a major cause of kidney failure worldwide, yet the precise roles of T cells in its pathogenesis remain poorly understood. However, existing studies lack a comprehensive understanding of the chara...
Autoantibodies against pentraxin-3 in systemic lupus erythematosus: mapping of reactivity to linear epitopes and associations with disease variables [0.03%]
系统性红斑狼疮中抗补体C反应蛋白3自身抗体：线性表位的鉴定及其与疾病的关系
Jesper Karlsson,Helena Enocsson,Hanna Duàn et al.
Jesper Karlsson et al.
The pentraxin-3 (PTX3) protein can activate and modulate complement and immune cells. IgG anti-PTX3 antibodies are suggested to protect against lupus nephritis (LN). This study aimed to evaluate anti-PTX3 IgG antibody levels across three rh...
Classification bias and impact of COVID-19 vaccination on all-cause mortality: the case of the Italian region Emilia-Romagna [0.03%]
新冠肺炎疫苗降低全因死亡率的分类偏倚及其影响——以意大利艾米利亚-罗马涅大区为例
Marco Alessandria,Giovanni Trambusti,Giovanni Maria Malatesta et al.
Marco Alessandria et al.
Real-world studies on vaccine effectiveness may suffer from several biases, typically distorting their results. A previous article on the population of an Italian province, correcting the "immortal time bias", showed worse results for the a...
High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell [0.03%]
高糖通过O-GlcNAc修饰ACSL4诱导肾小管上皮细胞铁死亡
Jing Qin,Zhisong Chen,Meiling Ye et al.
Jing Qin et al.
Objective: O-linked N-acetylglucosamine (O-GlcNAc) glycosylation represents a prevalent post-translational modification of proteins. Accumulating evidence indicates that dysregulated O-GlcNAcylation can induce glucose tox...
Multi-omics identification of RNASE6 as an immune regulatory RNA-binding protein associated with melanoma metastasis [0.03%]
多组学识别与黑色素瘤转移相关的免疫调节RNA结合蛋白RNASE6
Pengfei Gao,Xiaolu Gao,Xue Zeng et al.
Pengfei Gao et al.
Background: Cutaneous melanoma is a highly invasive tumor. It enhances metastasis and resistance to immunotherapy via immunosuppressive mechanisms. Understanding RNA-binding proteins (RBPs) in melanoma's immune alteration...
Immunogenic self-DNA drives neuropsychiatric systemic lupus erythematosus in conventional genetic background mice [0.03%]
免疫性自身DNA驱动常规遗传背景小鼠的神经精神系统性红斑狼疮发病
Fuyou Xu,Zhenke Wen,Sidong Xiong
Fuyou Xu
Neuropsychiatric systemic lupus erythematosus (NPSLE) represents a significant and growing challenge in both clinical practice and research, with its mechanistic investigation hindered by the lack of reliable animal models. Over the past tw...
Identification of cellular senescence-associated hub genes and molecular targeting mechanisms of thalidomide in lupus nephritis (LN) [0.03%]
系统性红斑狼疮的细胞衰老相关基因及氯喹和thalidomide的作用机制研究
Guowen Zhang,Yanting Li,Dongfang Huang et al.
Guowen Zhang et al.
Systemic lupus erythematosus (SLE), a chronic autoimmune disease, progresses to lupus nephritis (LN) in 50-60% of patients, driving end-stage renal disease (ESRD). Identifying LN-associated cellular senescence hub genes and drug targets is ...