Interleukin-2 is associated with cytopenias in systemic lupus erythematosus [0.03%]
白细胞介素-2与系统性红斑狼疮细胞减少症相关性研究
Miguel Á González-Gay,Fuensanta Gómez-Bernal,Juan C Quevedo-Abeledo et al.
Miguel Á González-Gay et al.
Interleukin 2 (IL-2) is a cytokine essential for the development and function of regulatory T cells, which are key players in maintaining immune tolerance by suppressing autoreactive lymphocytes. Patients with systemic lupus erythematosus (...
Compound kushen injection inhibits immune evasion of hepatocellular carcinoma cells via reducing O-GlcNAcylation of Pd-L1 [0.03%]
夏坤注射液通过降低PD-L1的O-连接糖基化抑制肝癌细胞免疫逃逸
Zhuo Lv,Jianyu Feng,Zijing Huang et al.
Zhuo Lv et al.
The advancement of hepatocellular carcinoma (HCC) is associated with metabolic reprogramming and immune escape. Compound kushen injection (CKI) is a cancer therapeutic agent with a long history. O-GlcNAcylation is reported to regulate tumor...
E4BP4 restrains effector-memory CD8+ T cell responses in systemic lupus erythematosus [0.03%]
E4BP4限制系统性红斑狼疮中效应记忆CD8+T细胞的反应
Ming Zhu,Suqing Zhou,Changxing Gao et al.
Ming Zhu et al.
Increasing evidence shows that CD8+ T cells are the pathogenic mediators of tissue injury in systemic lupus erythematosus (SLE), sustaining the chronic inflammation through the accumulation of long-lived cytotoxic memory populations. Howeve...
Investigating and validating the molecular mechanisms of lipid metabolism regulation in myasthenia gravis development based on single-cell, bulk transcriptomics, and RT-qPCR [0.03%]
基于单细胞、批量转录组和RT-qPCR探究和验证脂质代谢调控在重症肌无力发病中的分子机制
Meiqiu Chen,Fang Cai,Yawei Sun et al.
Meiqiu Chen et al.
Myasthenia gravis (MG) is a complex autoimmune neuromuscular disorder, and the role of lipid metabolism dysregulation in MG pathogenesis remains unclear. This study aimed to investigate the molecular mechanisms of lipid metabolism regulatio...
Interferon regulatory factor 1 mediates ROS-dependent release of NETs in LPS-induced mouse pneumonia by interacting with matrix metalloproteinase 9 [0.03%]
干扰素调节因子1通过与基质金属蛋白酶9相互作用介导脂多糖诱导的小鼠肺炎中ROS依赖性的NET释放
Yandan Wei,Wei Fu,Yanxia Liu et al.
Yandan Wei et al.
While interferon regulatory factor 1 (IRF1) has been implicated in reactive oxygen species (ROS)-dependent neutrophil extracellular trap (NET) release during acute lung injury, its regulatory role in mitochondrial dysfunction-driven NETosis...
Platycodin D attenuates proliferation, migration, and angiogenesis in RA-stimulated endothelial cells via CD146 modulation [0.03%]
北豆根苷D通过调节CD146抑制类风湿因子刺激的内皮细胞增殖、迁移和血管生成
Jing He,Peiting Li,Lan Wang et al.
Jing He et al.
Objective: To investigate the effects of Platycodin D (PD) on the proliferation, migration, and angiogenesis of EA.hy926 endothelial cells stimulated by supernatant from a rheumatoid arthritis (RA) synovial cell model (MH...
CCDC77 and SLC45A3 mediate the genetic mechanism of Hashimoto's thyroiditis through IL-6 [0.03%]
CCDC77和SLC45A3通过IL-6介导桥本甲状腺炎的遗传机制
Rui Wang,Yuhao Jiao,Shengjun Chai et al.
Rui Wang et al.
Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder with a complex genetic background. Interleukin-6 (IL-6) has been implicated in its pathogenesis, but the genetic mechanisms remain unclear. Two-sample Mendelian randomizat...
Multi-cohort transcriptomic analysis with machine learning identifies interferon-related candidate genes in systemic lupus erythematosus [0.03%]
基于多队列转录组及机器学习分析鉴定系统性红斑狼疮相关干扰素候选基因
Aishanjiang Apaer,Alimijiang Aobulitalifu,Jumahong Keyoumu et al.
Aishanjiang Apaer et al.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with complex molecular mechanisms. Although transcriptomic studies have revealed prominent interferon signatures in SLE, robust prioritization of candidate genes acros...
IgA Vasculitis with necrotizing arteritis: a multicenter retrospective study from the French Vasculitis Study Group and systematic review of the literature [0.03%]
IgA血管炎伴坏死性动脉炎的多中心回顾性研究及文献系统复习
Emmanuel Ribereau-Gayon,Amélie Carbonnelle-Puscian,Marie Ottavi et al.
Emmanuel Ribereau-Gayon et al.
IgA vasculitis (IgAV) primarily affects small vessels, but rare cases with necrotizing arteritis (NA) raise questions about overlap with polyarteritis nodosa (PAN). To characterize IgAV with necrotizing arteritis (IgAV-NA) and compare its p...
Multicenter Study
Autoimmunity. 2026 Dec 31;59(1):2677546. DOI:10.1080/08916934.2026.2677546 2026
Global research trends in ferroptosis in autoimmune diseases: a bibliometric and visual analysis (2018-2025) [0.03%]
自身免疫性疾病中铁死亡的研究趋势(2018-2025):基于文献的计量学和可视化分析
Ruohui Li,Kaichao Song,Qingbo Chen et al.
Ruohui Li et al.
To systematically examine global research trends in the association between ferroptosis and autoimmune diseases from 2018 to 2025, thereby informing future mechanistic and translational investigations in this field. On March 17, 2026, relev...