Integrated bioinformatics reveals tubulointerstitial immune microenvironment signatures and machine learning-driven prognostication of clinical treatment response in lupus nephritis [0.03%]
整合生物信息学揭示狼疮性肾炎的肾间质免疫微环境特征及临床治疗反应机器学习驱动预后模型
Jialong Ke,Guanghong Gu,Wenpeng Ni et al.
Jialong Ke et al.
Lupus nephritis (LN) represents the most severe renal manifestation of systemic lupus erythematosus (SLE), contributing to significant morbidity. While current assessments focus on glomerular pathology, tubulointerstitial lesions may offer ...
Long non-coding RNA H19 contributes to M1 macrophage polarization mediated inflammation via miR-145-5p-PAI-1 axis in systemic lupus erythematosus [0.03%]
长链非编码RNA H19通过miR-145-5p-PAI-1轴促进系统性红斑狼疮中M1型巨噬细胞极化介导的炎症反应
Cheng-Lei Zhao,Yong Zhang,Jun-Kai Guo et al.
Cheng-Lei Zhao et al.
Systemic lupus erythematosus (SLE) represents a prototypical autoimmune disorder characterized by multi-organ involvement due to loss of immune tolerance. Emerging evidence implicates macrophage polarization dynamics as a pivotal contributo...
CA72-4 derived from synovial cells inhibits monosodium urate-induced macrophage M1 polarization by activating the TIGIT/SHP-1 axis through binding to Siglec-15 [0.03%]
来源于滑膜细胞的CA72-4通过与Siglec-15结合激活TIGIT/SHP-1轴抑制尿酸盐诱导的巨噬细胞M1极化
Honglei Hu,Xuefeng Bai,Lingyue Zhang et al.
Honglei Hu et al.
Excessive M1 polarization of macrophages is a key driver of inflammatory processes in gout, while the regulatory mechanisms involved remain unclear. Herein, the role of carbohydrate antigen 72-4 (CA72-4), derived from human synovial cells (...
Molecular mechanism of Mir-27B-3P carried by bronchial epithelial cell-derived extracellular vesicle in airway inflammation in asthmatic mice [0.03%]
支气管哮喘小鼠模型中支气管上皮细胞源性外泌体介导的mir-27b-3p分子机制研究
Niu Ding,Siran Xu,Yanping Chen et al.
Niu Ding et al.
Asthma represents a classic respiratory disorder marked by chronic inflammation in the airways. This study aims to demonstrate the mechanism of bronchial epithelial cell-derived extracellular vesicles (BEC-EVs) carrying miR-27b-3p in airway...
Exploring the molecular mechanisms underlying the inflammation-cancer transformation in Hashimoto thyroiditis using single-cell transcriptomics [0.03%]
利用单细胞转录组学研究桥本甲状腺炎炎症至癌症转化的分子机制
Mengsha Zou,Shang Shi,Huihui Li et al.
Mengsha Zou et al.
Hashimoto thyroiditis (HT) is closely associated with the development of papillary thyroid carcinoma (PTC); however, the tumor immune microenvironment and the molecular mechanisms underlying the 'inflammation-to-cancer' transition in HT-PTC...
Identification of the immune-related diagnostic biomarkers between Graves' disease and thyroid carcinoma based on comprehensive bioinformatics analysis and machine learning [0.03%]
基于综合生物信息学分析和机器学习鉴别桥本病与甲状腺癌之间免疫相关诊断标志物
Yanting Zhu,Xiaoyu Qu,Jingying Pan et al.
Yanting Zhu et al.
Increasing evidence suggests that Graves' disease (GD) may increase the risk of thyroid cancer (THCA), but diagnostic biomarkers associated with it remain underexplored. To address this issue, we analyzed the Gene Expression Omnibus (GEO) a...
The shared mechanisms and potential diagnostic markers for IgA nephropathy and celiac disease [0.03%]
IgA肾病和乳糜泻的共享机制及潜在诊断标志物
Shaoguo Tao,Xuemei Fan,Xiaoyou Liu et al.
Shaoguo Tao et al.
IgA nephropathy (IgAN) and celiac disease (CeD) are autoimmune disorders characterized by dysregulated immune responses; however, the molecular mechanisms underlying their comorbidity remain incompletely understood. Here, we integrated tran...
Exosomal circ_001895 from lung cancer cells drives M2 macrophage polarization via the miR-20a-5p/JAK1/STAT3 axis to promote tumor progression [0.03%]
肺癌细胞来源的circ_001895通过miR-20a-5p/JAK1/STAT3轴驱动M2型巨噬细胞极化促进肿瘤进展
Zunqiao Wang,Bin Wang,Yun Gao et al.
Zunqiao Wang et al.
Exosomes play a vital role in cancer cell and tumor microenvironment (TME) crosstalk. M2 macrophages are major immune cells in the TME. However, the effects and molecular mechanisms by which exosomes secreted by lung cancer (LC) cells regul...
Transcriptomic subtyping of COVID-19 reveals three distinct immune response profile [0.03%]
基于转录组的新冠肺炎分型揭示了三种免疫特征响应类型
Feifei Qiao,Yuhui Zhao,Kaixin Yao et al.
Feifei Qiao et al.
The current clinical classification of coronavirus disease 2019 (COVID-19) does not adequately capture the biological heterogeneity observed among patients. To address this gap, the present study aimed to identify distinct subtypes of sever...
Hemlata Bisnauthsing,Kelvin K L Chong,Clement C Tham et al.
Hemlata Bisnauthsing et al.
Thyroid eye disease (TED) is an autoimmune inflammatory disease involving the extraocular tissues. It often occurs in patients with hyperthyroidism or a history of hyperthyroidism; however, it can also occur in euthyroid or hypothyroid pati...