Suppression of circ_0091761 ameliorates acute myocardial infarction-induced endothelial injury through regulation of miR-1278 [0.03%]
circ_0091761通过调节miR-1278缓解急性心肌梗死诱导的内皮损伤
Bin Zhou,Haitao Wang,Kun Zhang et al.
Bin Zhou et al.
Objective: The main objective of the article was to explore the role of circ_0091761 in acute myocardial infarction (AMI)-induced endothelial injury. Meth...
RBM15 enhances paclitaxel resistance in triple-negative breast cancer by targeting m6A methylation of TNFSF9 and inducing polarization of tumor-associated macrophages to M2 phenotype [0.03%]
RBM15通过靶向TNFSF9 mRNA的m6A甲基化增强三阴性乳腺癌的紫杉醇耐药并诱导肿瘤相关巨噬细胞极化为M2表型
Jinkun Fu,Chao Wei,Yijian Chen et al.
Jinkun Fu et al.
Background: Triple-negative breast cancer (TNBC) is one of the breast cancer subtypes with a poor prognosis, and the current main treatment modalities include surgical resection and adjuvant chemotherapy. However, the dev...
Multi-Omics analysis and in vitro validation reveal diagnostic and therapeutic roles of novel hub genes in ovarian cancer [0.03%]
多组学分析和体外验证揭示卵巢癌中新型枢纽基因的诊断和治疗作用
Jianmin Wang,Guanghui Song,Lili Xing
Jianmin Wang
Ovarian cancer (OC) remains a highly lethal gynecologic malignancy due to late diagnosis and limited therapeutic options. In this study, we aimed to identify and functionally validate novel hub genes associated with OC progression. We integ...
Identification of anoikis-related genes in heart failure: bioinformatics and experimental validation [0.03%]
生物信息学和实验验证识别心脏衰竭相关的脱离附着诱导的细胞程序性死亡基因
Lina Zhang,Jianjun Gu,Yan Jiang et al.
Lina Zhang et al.
Background: Heart failure (HF) is a common clinical syndrome caused by ventricular dysfunction and one of the leading causes of mortality worldwide. Previous studies have suggested that anoikis is relevant to HF. This stu...
β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways [0.03%]
烟酰胺单核苷酸通过激活NAD + / SIRT1信号通路缓解酒精小鼠模型肝损伤
Xinxin Yang,Endian Zheng,Yuxian Lin et al.
Xinxin Yang et al.
Background: Alcoholism is a significant contributor to the development of alcoholic liver disease, for which no universally accepted and effective treatment currently exists. A precursor of NAD+, β-Nicotinamide mononucle...
Programmed death 1 inhibitor combined with radiotherapy decreases epidermal growth factor receptor expression in breast cancer [0.03%]
程序性死亡配体-1抑制剂联合放疗可降低乳腺癌上皮生长因子受体表达
You Wu
You Wu
Objective: To investigate the effect of programmed death 1 (PD-1) inhibitors combined with radiotherapy on the expression of P53 and epidermal growth factor receptor (EGFR) in breast cancer (BC). The impact of radiation t...
Global trends in machine learning applications for single-cell transcriptomics research [0.03%]
单细胞转录组学研究中机器学习应用的全球趋势分析
Xinyu Liu,Zhen Zhang,Chao Tan et al.
Xinyu Liu et al.
Background: Single-cell RNA sequencing (scRNA-seq) has revolutionized cellular heterogeneity analysis by decoding gene expression profiles at individual cell level, while machine learning (ML) has emerged as core computat...
A comprehensive in silico and invitro analysis revealed the diagnostic, prognostic and therapeutic potential of GNAI family genes in colon adenocarcinoma (COAD) [0.03%]
全面的计算和体外分析揭示了GNAI家族基因在结肠腺癌中的诊断、预后和治疗潜力
Bei Wang,Fan Zhu,Yingying Chen
Bei Wang
Introduction: Guanine nucleotide-binding protein alpha inhibiting activity polypeptides (GNAI1, GNAI2, and GNAI3) play critical roles in cell cycle regulation, intracellular signaling, and immune modulation. However, thei...
Multi-omics approach reveals CCND1, GABPA, HIF1A, and SOX6 as key regulators and prognostic markers in heart failure [0.03%]
多组学方法揭示CCND1、GABPA、HIF1A和SOX6是心力衰竭中的关键调节因子和预后标志物
Ping He,Lang Deng,Kaijie Wu
Ping He
Introduction: Heart failure (HF) is a progressive condition with complex molecular mechanisms. This study aims to identify potential biomarkers and therapeutic targets by analyzing differentially expressed genes (DEGs) in...
COL1A1, ITGB1, THY1, and PDGFRA: key immune-related genes in uterine corpus endometrial carcinoma with prognostic and therapeutic implications [0.03%]
COL1A1，ITGB1，THY1和PDGFRA：与子宫体子宫内膜癌免疫相关的关键基因及其预后和治疗意义
Taghreed N Almanaa,Abdulaziz Alamri,Mostafa A Abdel-Maksoud et al.
Taghreed N Almanaa et al.
Uterine corpus endometrial carcinoma (UCEC) is one of the most common gynecological malignancies, characterized by complex molecular alterations that drive its progression. Understanding the molecular mechanisms underlying UCEC is crucial f...