Multimethodological and multiscale investigation of the therapeutic mechanism of Qian Ji Sheng Xue Pian in treating primary immune thrombocytopenia [0.03%]
千嘉生血片治疗原发免疫性血小板减少症的多方法、多尺度机制探究
Yujue Wang,Chengyan Liu,Xiaoqi Sun et al.
Yujue Wang et al.
Background: For more than 30 years, Qian Ji Sheng Xue Pian (QJSXP) has been used clinically to treat primary immune thrombocytopenia (ITP) with good documented efficacy. However, nothing is known about its underlying mech...
Performance of a self-developed panel for biogeographic ancestry inference and dissection of the genetic background of three Tibetan groups [0.03%]
一种用于推断生物地理祖先的新型芯片面板的性能评估及其在三大藏族群体遗传背景解析中的应用研究
Yifeng Lin,Xi Yuan,Xi Wang et al.
Yifeng Lin et al.
The diagnostic value and mechanism of miR-127-3p in type 2 diabetes and complications of diabetic nephropathy [0.03%]
miR-127-3p在2型糖尿病及糖尿病肾病并发症中的诊断价值和作用机制研究
Lili Du,Hong Xia,Lingbo Lv et al.
Lili Du et al.
Background: Diabetic kidney disease (DKD) is a serious microvascular complication of type 2 diabetes mellitus (T2DM). miR-127-3p is dysregulated in T2DM, but the specific molecular mechanism remains unclear. We aim to pro...
Optical genome mapping of a complex structural rearrangement family line on chromosome 18 [0.03%]
十八号染色体复杂结构重排家系的光学基因组图谱分析
Liyi Cai,Yuying Jiang,Na Zhang et al.
Liyi Cai et al.
Background: Complex chromosomal rearrangement (CCR) refers to a structural rearrangement involving at least two chromosomes or a minimum of three breakpoints. CCR may lead to intellectual disability, structural anomalies,...
Case Reports
Hereditas. 2025 Dec 2;162(1):235. DOI:10.1186/s41065-025-00602-5 2025
miR-223-3p predicts prognosis of hepatitis B virus-related acute-on-chronic liver failure and is involved in hepatocyte injury via HSP90B1 [0.03%]
microRNA-223-3p预测乙型肝炎病毒相关急性-on-慢性肝功能衰竭的预后并通过HSP90B1参与肝细胞损伤
Feiyue Xie,Qiuping Ren,Jun He et al.
Feiyue Xie et al.
MiR-4701-3p predicts prognosis of non-small cell lung cancer and regulates cell biological behaviors [0.03%]
MiR-4701-3p预测非小细胞肺癌预后并调控细胞生物学行为
Zhenhua Hao,Yitao Sun,Guangfu Xu et al.
Zhenhua Hao et al.
Background & objectives: Non-small cell lung cancer (NSCLC) represents a malignant neoplasm exhibiting high incidence and mortality rates, marked by diminished patient survival probabilities and an unfavorable prognosis. ...
LncRNA LEF1-AS1 exerts a carcinogenic effect in breast cancer by accelerating proliferation, metastasis, and epithelial-mesenchymal transition [0.03%]
长链非编码RNA LEF1-AS1通过促进增殖、转移和上皮间质转化在乳腺癌中发挥致癌作用
Linna Kong,Jiaqi Liu,Huihui Zhang et al.
Linna Kong et al.
Integrative multi-omics and single-cell transcriptomics reveal ARHGEF12 driving chemoresistance in bladder cancer [0.03%]
整合多组学和单细胞转录组揭示ARHGEF12驱动膀胱癌化疗耐药性
Kunyao Zhu,Zhejiao Zhang,Tinghao Li et al.
Kunyao Zhu et al.
Bladder cancer (BLCA) is the predominant type of urothelial carcinoma in urinary system, and resistance to cisplatin-based chemotherapy substantially worsens clinical outcomes, presenting a major therapeutic obstacle. In this study, we inte...
CAFs-derived SPI1 in tumor fibroblasts promotes malignant behaviors of liver cancer cells and immune escape by regulating HRAS and PD-L1 transcription [0.03%]
肿瘤相关成纤维细胞中CAF来源的SPI1通过调节HRAS和PD-L1转录促进肝癌细胞恶性行为和免疫逃逸
Ke Miao,Jiaren Zhou,Jieyun Chen
Ke Miao
Background: As the fifth most common cancer worldwide, hepatocellular carcinoma (HCC) is a highly malignant disease with a formidable prognosis. Within the tumor microenvironment, cancer-associated fibroblasts (CAFs) play...
A mitochondrial permeability transition-associated lncRNA signature predicts prognosis and the immune response in gastric cancer [0.03%]
与胃癌预后和免疫反应相关的线粒体通透性转换相关长链非编码RNA标志物
Hao Hu,Ya Song,Sixia Jiang et al.
Hao Hu et al.