miR-335-3p acts as a tumor suppressor in esophageal squamous cell carcinoma and predicts favorable prognosis [0.03%]
MiR-335-3p在食管鳞癌中发挥抑癌作用并提示良好预后
Miao He,Shuojun Lu,Feng Yang et al.
Miao He et al.
Background: Esophageal cancer is a highly invasive malignancy that severely impairs normal digestive function and poses a substantial threat to patient survival. The pathogenesis of miRNA-mediated tumors has been widely d...
SNP rs7430456 mediated LINC00578 drives triple negative breast cancer through regulating miR-143-5p expression [0.03%]
SNP rs7430456 介导的 LINC00578 通过调节 miR-143-5p 表达驱动三阴性乳腺癌
Jing Zhai,Wei Wu,Xiaoyun Mao et al.
Jing Zhai et al.
Background: A large number of cancer-related single-nucleotide polymorphisms (SNPs) are distributed in the genomic regions of long non-coding RNAs (lncRNAs), yet the mechanisms linking them to cancer risk have not been fu...
BFLF1 gene polymorphisms are associated with increased mortality in patients with EBV-associated diseases [0.03%]
EB病毒相关性疾病患者的BFLF1基因多态性与死亡率增加有关
Xurong Li,Jing Wu,Shenglei Yu et al.
Xurong Li et al.
Objective: Epstein-Barr virus (EBV) -associated diseases comprise a spectrum of conditions, including infectious mononucleosis (IM) and chronic active EBV infections (CAEBV), as well as malignant lymphomas. The study aime...
miR-1-3p, as a novel diagnostic and prognostic biomarker, aggravates pancreatic acinar cell injury in acute pancreatitis by targeting GNPTAB [0.03%]
microRNA-1-3p通过靶向GNPTAB作用的新诊断和预后生物标志物急性胰腺炎中的微小核糖核酸-1-3p加速胰腺外分泌细胞的损伤研究
Haibin Huang,Jinyu Liu,Lianjun Wu et al.
Haibin Huang et al.
Objective: The mechanisms underlying the progression of acute pancreatitis (AP) remain incompletely elucidated. This study investigates the expression pattern, diagnostic and prognostic value of miR-1-3p in AP patients, a...
Identification of FOXK1 and SEMA7A as key genes associated with m6A-related programmed cell death in diabetic retinopathy [0.03%]
糖尿病视网膜病变中m6A相关程序性细胞死亡关键基因FOXK1和SEMA7A的鉴定
Jie Yang,Zhenyu Wu,Ningning Dong
Jie Yang
Background: Diabetic retinopathy (DR), a serious microvascular complication of diabetes, has a complex pathogenic mechanism that is intricately linked to programmed cell death (PCD) and also to N6-methyladenosine (m6A) mo...
miR-146b-5p serves as a novel biomarker for acute myocardial infarction and is involved in regulating oxidized low-density lipoprotein-induced endothelial injury through targeting PRKAR2A [0.03%]
microRNA-146b-5p可作为新型生物标志物用于急性心肌梗死的诊断并通过靶向蛋白激酶A调节亚基RIIα介导氧化型低密度脂蛋白诱导的内皮细胞损伤
Hailiang Wu,Hui Zhang,Yuyan Hou et al.
Hailiang Wu et al.
Background: MiR-146b-5p, a disease-responsive miRNA with circulatory stability, has been implicated in multiple pathologies, but its role in acute myocardial infarction (AMI) remains unexplored. The objective of this stud...
Whole blood miRNA expression signatures as predictors of neoadjuvant chemotherapy response in triple-negative breast cancer [0.03%]
三阴性乳腺癌新辅助化疗疗效预测的全血微阵列标志物研究
Monika Drobniene,Domas Stitilis,Linas Kunigenas et al.
Monika Drobniene et al.
Background: Triple negative breast cancer (TNBC) is an aggressive malignancy distinguished by resistance to standard breast cancer therapies. The absence of reliable prognostic tools hinders the ability to predict therape...
Identification and experimental validation of biomarkers associated with T cell infiltration in psoriasis [0.03%]
银屑病T细胞浸润相关的生物标志物的鉴定与实验验证
Li Zhang,Xiao-Yan Yang,Fa-Zeng Li et al.
Li Zhang et al.
Background: Psoriasis represents a prevalent long-term inflammatory skin condition marked by the dysregulation of immune responses. T cells are integral to the pathogenesis of psoriasis. This study conducted a comprehensi...
M2 macrophage-derived exosomes promote the malignant progression and glycolysis of cervical cancer via Msi1 [0.03%]
M2型巨噬细胞源性外泌体通过Msi1促进宫颈癌恶性进展及糖酵解
Liting Sun,Abudureyimu Tunishahan,Xiaowen Li
Liting Sun
Background: Cervical cancer is a common gynecologic malignancy characterized by high recurrence and metastasis rate. Exosomes derived from M2-polarized tumor-associated macrophages play a key role in promoting tumorigenes...
KLF5 promotes proliferation, migration, and autophagy-/EMT‑associated molecular changes in lens epithelial cells via transcriptional activation of THBS1 in traumatic cataract [0.03%]
KLF5通过转录激活THBS1促进创伤性白内障晶状体上皮细胞增殖、迁移及自噬/上皮间充质转化相关分子改变
Junjun Han,Tian Wang,Xin Yang et al.
Junjun Han et al.
Purpose: Traumatic cataract is a common blinding eye disease after ocular trauma, and its pathogenesis is closely related to lens epithelial cell dysfunction, while the definite molecular regulatory mechanism between upst...