Qingxie Fuzheng granules attenuate cancer cachexia by restoring gut microbiota homeostasis and suppressing IL-6/NF-κB signaling in colorectal adenocarcinoma [0.03%]
清燮扶正颗粒通过恢复肠道菌群稳态和抑制白细胞介素-6/核因子-κB信号通路治疗结肠腺癌恶病质
Yishun Jin,Lisha Lu,Hangju Hua et al.
Yishun Jin et al.
Cancer cachexia, a debilitating syndrome characterized by muscle wasting and systemic inflammation, remains a major unmet clinical need. Qingxie Fuzheng Granules (QFG), a traditional Chinese medicine formulation, have shown promise in cance...
RBM15 promotes COAD progression by regulating the m6A modification of TMC5 [0.03%]
RBM15通过调节TMC5的m6A修饰促进结肠腺癌进展
Errong Tian,Li Gao,Lan Wu et al.
Errong Tian et al.
Background: Colon adenocarcinoma (COAD) is a frequent digestive system malignancy with high mortality and poor prognosis. Transmembrane Channel-like 5 (TMC5) has been reported to play an oncological role in various cancer...
Decoding the PTTG family's contribution to LUAD pathogenesis: a comprehensive study on expression, epigenetics, and therapeutic interventions [0.03%]
PTTG家族在LUAD发病机制中的贡献解码：表达、表观遗传和治疗干预的全面研究
Jinna Di,Li Tian,Fan Yan et al.
Jinna Di et al.
Background: Lung adenocarcinoma (LUAD) stands as a prevalent malignancy, yet its pathology remains incompletely comprehended. Methods: ...
HOXA13 promotes high glucose-induced trophoblast cell growth and migration during gestational diabetes by regulating the smad2 pathway [0.03%]
HOXA13通过调节smad2通路促进高糖诱导的妊娠糖尿病滋养细胞增殖和迁移
Fei Zhao,Xinhong Liu,Hong Qin
Fei Zhao
Background: Gestational diabetes mellitus (GDM) is considered the most common complication of pregnancy, and is a very dangerous disease for both mother and baby. Homeobox A13 (HOXA13) has been discovered to join into som...
Integrated single-cell and bulk transcriptomic profiling reveals cancer-associated fibroblast heterogeneity in glioblastoma and establishes a clinically actionable prognostic model and preliminary experimental validation [0.03%]
整合单细胞和批量转录组分析揭示胶质母细胞瘤相关成纤维细胞异质性并建立了一个具有临床可操作性的预后模型及初步实验验证
Wenhua Zhang,Yaxiong Li,Conghui Li et al.
Wenhua Zhang et al.
Cancer-associated fibroblasts (CAFs) critically regulate tumor progression, angiogenesis, metastasis, and therapeutic resistance. This study investigated the characteristics of CAFs in glioblastoma (GBM) and developed a CAF-based risk signa...
Research landscape of photodynamic therapy for hepatocellular carcinoma: Hotspots and Prospects from 2012 to 2025 [0.03%]
2012-2025年光动力疗法治疗肝细胞癌的研究热点与发展前景展望
Fei Yu,Sihan Yin,Jiayu Zhu et al.
Fei Yu et al.
Objective: To explore the current status and future development of photodynamic therapy (PDT) for hepatocellular carcinoma (HCC). However, this field lacks a comprehensive bibliometric analysis. This study aims to investi...
The methylation site cg06972019 regulates the succinylation-related gene ENO1 to inhibit the occurrence of erectile dysfunction [0.03%]
甲基化位点cg06972019通过调控琥珀酰化相关基因ENO1抑制勃起功能障碍发生
Jian Wang,Siyuan Ye,Maoxiao Xu et al.
Jian Wang et al.
Background: This study aims to explore the causal relationship between the expression of succinylation-related genes and erectile dysfunction (ED). Method...
The diagnostic and prognostic value of LncRNA FAM3D-AS1 expression in nasopharyngeal carcinoma and its effect on tumor progression and cisplatin resistance [0.03%]
长链非编码RNA FAM3D-AS1在鼻咽癌中的诊断及预后价值及其对肿瘤进展和顺铂耐药的影响
Bohan Zhang,Zixiao Chen,Zhinong Wu
Bohan Zhang
Background: The location of nasopharyngeal carcinoma (NPC) is relatively hidden. Most patients are diagnosed at the middle or late stage of the disease, having missed the best time for treatment. ...
Damnacanthus giganteus extract block diffuse large b-cell lymphoma proliferation and EMT by regulating mitochondrial dysfunction and glycolysis [0.03%]
大花马钱素通过调节线粒体功能障碍和糖酵解阻断弥漫性大B细胞淋巴瘤的增殖和上皮间质转化
Peng Yang,GuangYun Zhou,XiuMei Ma et al.
Peng Yang et al.
Background: In non-Hodgkin's lymphoma, diffuse large b-cell lymphoma (DLBCL) is one of the most prevalent and commonly diagnosed subtypes. There is a need to develop more effective drugs since the currently approved drugs...
Hypoxia-associated genes and metabolic abnormalities in peripheral blood mononuclear cells of type 1 diabetes mellitus patients [0.03%]
1型糖尿病患者外周血单个核细胞缺氧相关基因及代谢异常
Wen-Biao Ma,Xue-Ying Wang,Yuan-Yuan Zuo
Wen-Biao Ma
Background: Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disorder characterized by insulin deficiency, which causes hyperglycemia and systemic metabolic dysregulation. ...