Integrated single-cell and bulk transcriptome analysis revealed high plasticity subpopulation and promising diagnosis model for clear cell renal cell carcinoma [0.03%]
整合单细胞和批量转录组分析揭示了透明细胞肾细胞癌的高度多能亚群及有前景的诊断模型
Zhongwen Lu,Fanyi Kong,Jiahuan Sun et al.
Zhongwen Lu et al.
Clear cell renal cell carcinoma (ccRCC) is a highly heterogeneous tumor that lacks reliable biological markers for diagnosis and prognostic monitoring. Currently, the differentially expressed genes between paired adjacent normal tissues and...
Impact of early blood purification on serum inflammatory mediators and hemorheology in severe acute pancreatitis [0.03%]
早期血液净化对重症急性胰腺炎患者血清炎症介质及血液流变性的影响
Jing Xiao,Bo Li
Jing Xiao
Background: Patients with severe acute pancreatitis (SAP) often experience systemic inflammatory responses and microcirculatory disturbances, for which existing treatments have limited intervention effects. ...
Randomized Controlled Trial
Hereditas. 2025 Sep 29;162(1):197. DOI:10.1186/s41065-025-00538-w 2025
C-X-C chemokine receptor family genes in osteosarcoma: expression profiles, regulatory networks, and functional impact on tumor progression [0.03%]
骨肉瘤中的C-X-C趋化因子受体家族基因：表达谱、调节网络及其对肿瘤进展的功能影响
Siqi Dong,Han Xu,Xianglei Kong et al.
Siqi Dong et al.
In this comprehensive study, we explored the molecular landscape C-X-C chemokine receptor (CXCR) family genes (CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7) in osteosarcoma (OS) by scrutinizing the expression profiles and functional implica...
Qushi huayu decoction dose-dependent inhibition of caspase-2/SREBP-1 in MASLD mice [0.03%]
清疏化瘀汤剂量依赖性抑制肝星状细胞CASPASE-2/SREBP-1通路诱导的棕榈酸引起的小鼠代谢异常综合征脂肪肝发病机制研究
Qian Liu,Zuxi Gu,Xin Xin et al.
Qian Liu et al.
Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is characterized by hepatic lipid accumulation and metabolic disturbances. Caspase-2 cleaves site-1 protease (S1P), leading to the persistent ac...
Investigating the effect of tenuigenin on LPS-induced HPMEC dysfunction by inhibiting SRC activation based on network pharmacology and molecular docking [0.03%]
基于网络药理学和分子对接探究天女花素通过抑制SRC活化改善LPS诱导的HPMEC功能障碍的作用机制研究
Jingchao Chen,Hao Pan,Jinchun Wang et al.
Jingchao Chen et al.
Background: Adult pneumonia is an infectious lung disease caused by bacteria, viruses, or other microorganisms and exhibits some degree of contagion. Tenuigenin, a bioactive compound derived from Polygala tenuifolia, poss...
Shenling Baizhu San attenuates testicular spermatogenic dysfunction in hyperuricemic mice via dual modulation of MAPK/NF-κB and NLRP3 inflammasome pathways [0.03%]
Shenling Baizhu San通过双重调节MAPK/NF-κB和NLRP3炎性小体通路缓解高尿酸血症小鼠睾丸生精功能障碍
Xiaocui Jiang,Zhongyi Zhu,Qi Liu et al.
Xiaocui Jiang et al.
Context: Hyperuricemia (HUA) is a known factor contributing to testicular spermatogenic dysfunction. Shenling Baizhu San (SLBZS), a traditional Chinese medicine compound, has demonstrated efficacy in reducing uric acid le...
HOXB13 affects the cancer stem cell characteristics of nasopharyngeal carcinoma by regulating the Wnt/β-catenin/SOX2 pathway [0.03%]
HOXB13通过调控Wnt/β-catenin/SOX2信号通路影响鼻咽癌干细胞特性
Ying Xu,Xia Li
Ying Xu
Purpose: HOXB13 has been shown to act as a tumor promoter in various malignancies; however, its role in nasopharyngeal carcinoma (NPC) remains unexplored. This study aimed to investigate the function of HOXB13 in NPC and ...
Why Hereditas leads hereditary cancer awareness now more than ever [0.03%]
为什么赫瑞蒂卡斯在遗传性癌症意识方面引领现在比以往任何时候都重要
Julhash U Kazi,Ramin Massoumi
Julhash U Kazi
Identification and experimental validation of biomarkers associated with the endocannabinoid system in major depressive disorder [0.03%]
抑郁症相关内源大麻素系统生物标志物的鉴定及实验验证
Linlin Wang,Min Chen,Xujuan Li et al.
Linlin Wang et al.
Background: The endocannabinoid system (ES) plays a pivotal role in modulating central nervous system activity in response to emotional stimuli. This study aimed to identify and validate biomarkers associated with ES-rela...
Metabolic heterogeneity and survival outcomes in papillary renal cell carcinoma: insights from multi-datasets and machine learning analyses [0.03%]
基于多数据集和机器学习分析的乳头状肾细胞癌代谢异质性及预后研究
Jian Hu,Yi-Heng Liu,Gui-Lian Xu et al.
Jian Hu et al.
Background: Renal cell carcinoma is characterized by immune and metabolic alterations. These metabolic reprogramming processes enhance tumor cell proliferation and infiltration. The purpose of this study was to investigat...