BMAL1 alleviates sepsis-induced acute kidney injury by inhibiting apoptosis, ferroptosis and inflammation [0.03%]
BMAL1通过抑制凋亡、铁死亡和炎症缓解脓毒症诱导的急性肾损伤
Zhipan Chen,Gaoze Chen,Jinhui Shi et al.
Zhipan Chen et al.
Background: Sepsis is a life-threatening syndrome characterized by organ dysfunction. The kidney is one of the earliest organs to be injured during sepsis. Basic Helix-Loop-Helix ARNT Like 1 (BMAL1) was shown to play a cr...
Quantitative study and related factors analysis of sciatic neuropathy in type 2 diabetes mellitus patients by elastic imaging virtual tissue imaging quantification technique [0.03%]
定量弹性超声在2型糖尿病周围神经病变患者中的研究及相关因素分析
Ruixing Liu,Beibei Yu,Gaopan Cao et al.
Ruixing Liu et al.
Background: The incidence of diabetic peripheral neuropathy (DPN) is increasing every year for type 2 diabetes mellitus (T2DM) patients, and diabetic polyneuropathy is a common type. ...
Hsa_circ_0071271 affected the progression of non-small cell lung cancer through miR-23a-5p [0.03%]
CircRNA Hsa_circ_0071271通过miR-23a-5p影响非小细胞肺癌进展
Ye Wu,Ling Zhang,Wenhui Li et al.
Ye Wu et al.
Background: Lung cancer ranks among the most prevalent malignancies globally, with non-small cell lung cancer (NSCLC) constituting the predominant subtype. Currently, there are limitations in the treatment options and pro...
Regulatory effect of miR-142-5p on inflammatory process of sepsis by targeting CXCL8 [0.03%]
miR-142-5p通过靶向CXCL8调节脓毒症炎性过程的机制研究
Ling Wu,Qiqi Shen,Xue Yu et al.
Ling Wu et al.
Background: Sepsis is a life-threatening systemic inflammatory response triggered by infection. The rapid progression of the disease necessitates early diagnosis and precise intervention, making the identification of reli...
Single-cell RNA sequencing reveals that Danggui Buxue Tang decoction facilitates wound healing after anal fistula by promoting M2 macrophage polarization [0.03%]
单细胞RNA测序揭示当归补血汤通过促进M2型巨噬细胞极化来加速肛瘘术后伤口愈合
Xue Pang,Yutao Wang,Jianzhuang Guo
Xue Pang
Background: We aim to employ single-cell RNA (scRNA) sequencing technology to investigate potential regulatory mechanism of Danggui Buxue Tang (DBT) in wound healing for its utilization in post-anal fistula surgery recove...
Identification of target genes of Astragalus mongholicus and Saposhnikovia divaricata extracts in human synoviocytes for potential osteoarthritis treatment [0.03%]
基于人滑膜细胞靶基因筛选蒙花豆和防风提取物抗骨关节炎潜力研究
Jiarui Zhou,Xiaopei Gao,Xing Liu et al.
Jiarui Zhou et al.
Osteoarthritis (OA) is a leading cause of pain and disability worldwide. Despite extensive research, no curative treatment is currently available. Most therapies focus on symptom relief or disease modification. Traditional Chinese medicines...
CircRNA-14052 promotes breast cancer progression via miR-214-3p/IKBKB pathway [0.03%]
Circular RNA-14052通过miR-214-3p/IKBKB途径促进乳腺癌进展
Donghai Li,Zhiying Zhang,Yan Cui et al.
Donghai Li et al.
Objectives: Circular RNAs play crucial regulatory roles in the progression of human diseases. This study aimed to investigate the functional mechanism of circRNA-14,052 in breast cancer progression. ...
Inhibition of ferroptosis-related NCF2 blocks the progression of lupus nephritis by activating PPARα pathway [0.03%]
NCF2铁死亡通路被抑制通过激活PPARα通路阻止狼疮性肾炎的发展
Shiling Zhong,Yunyan Li,Yuanling Chen et al.
Shiling Zhong et al.
Background: Ferroptosis is involved in the pathogenesis of Lupus nephritis (LN), but its mechanism of action in LN remains unknown. This study aims to explore the effect of the ferroptositic-related gene neutrophil cytoso...
Regulatory role of ezrin in esophageal cancer progression via the PI3K-AKT signaling pathway [0.03%]
ezrin通过PI3K-AKT信号通路在食管癌进展中的调控作用
Yuefeng Zhang,Qifeng Zhao,Jie Du
Yuefeng Zhang
Background: The progression of esophageal cancer (EC) has been associated with aberrant activation of oncogenes and suppression of tumor suppressor genes. The EZR gene encodes ezrin, which is highly activated and upregula...
Multi-omics Mendelian randomization integrating RNA-seq, eQTL and pQTL data revealed CPXM1 as a potential drug target for osteoporosis [0.03%]
整合RNA测序、表达定量性状基因座和表型定量性状基因座数据的多组学孟德尔随机化研究揭示了CPXM1是治疗骨质疏松症的潜在药物靶点
Junxiang Lian,Xinjian Zhang,Shanwei Shi et al.
Junxiang Lian et al.
Osteoporosis, a prevalent skeletal disorder characterized by decreased bone mineral density and increased fracture risk, continues to be a major global health concern. Traditional treatments for osteoporosis have limited efficacy and safety...